Search Results - therapeutics

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Adaptive Exercise-Enabled Proportional-Derivative Artificial Pancreas Control Algorithm
This is an adaptive proportional-derivative (APD) control algorithm that provides automated delivery amounts of insulin and optionally glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. The APD algorithm includes a safety layer decision tree to prevent dosing of...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Adaptive Exercise-Enabled Model-Predictive-Control Artificial Pancreas Control Algorithm
This is a model-predictive control (MPC) algorithm that provides automated delivery amounts of insulin and, optionally, glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. Dosing insulin after meals can be challenging and can lead to hyperglycemia or late-term hypoglycemia...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Method of Producing Human Pluripotent Stem Cells by Somatic Cell Nuclear Transfer
This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). PSC’s only naturally exist in early human embryos. Methods are described to produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin cells as a starting point. Human PSC’s...
Published: 8/5/2020   |   Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana
Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
Small molecule activates innate immune responses controlled by the human protein STING.
Researchers at OHSU have discovered a novel small molecule agonist of human protein STING that may be administered either as an adjuvant to a vaccine or as independent therapy for treatment of infectious disease and/or cancer.
Published: 6/30/2020   |   Inventor(s): Victor DeFilippis, Jinu Abraham, Sara Botto
Keywords(s): Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Vaccines, Therapeutics
New Drugs for Treatment of Type 1 Diabetes
Technology Description Oregon State University is seeking a licensee to develop and commercialize a new family of compounds that target the Ah receptor for treatment of Type 1 Diabetes. The compounds are based on the parental compound 11-Cl-BBQ, the use of which is described PCT patent application No. US2015/057873, in U.S. patent No. 10,308,649, and...
Published: 6/23/2020   |   Inventor(s): Jit Chakravarty, Nancy Kerkvliet, Siva Kolluri, Sebastian Bernales
Keywords(s): Diabetes, pharmaceuticals, Therapeutic, Type 1 Diabetes
Category(s): Therapeutics
Substituted Phenols and Benzenes for Pharmaceuticals, Agrochemicals and Synthetic Materials
Technology Description This technology licensing opportunity is for novel phenol and benzene compounds with any number of substituents and complete positional selectivity. Synthesis of the compounds is achieved by a new synthetic method. The method provides a one-step conversion of readily available starting materials to give phenols with complete...
Published: 5/20/2020   |   Inventor(s): Chris Beaudry, Xiaojie Zhang
Keywords(s): agrochemical, benzenes, chemistry, medicinal, organic, pharmaceuticals, phenols, polymer, substituted, synthesis
Category(s): Agricultural, Chemical, Therapeutics
Antiviral Agents Against Enveloped Viruses
Technology Description This technology licensing opportunity is for patent pending methods for killing enveloped viruses, such as coronaviruses. It involves the application of known surfactants at concentrations much lower than were previously recognized as useful. Specifically, the compositions comprise highly purified surfactants at concentrations...
Published: 5/19/2020   |   Inventor(s): Ling Jin
Keywords(s): antiviral, corona, coronavirus, covid-19, envelop, viral, virus
Category(s): Chemical, Medical Devices, Therapeutics
Treatment for Hypertension
Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...
Published: 1/7/2020   |   Inventor(s): Patrick Iversen, Andrew Annalora
Keywords(s): Hypertension, Pharmaceuticals, Transplantation
Category(s): Therapeutics
Enhancing Radiation for Treatment of Cancer
Technology Description This licensing and collaborative research opportunity relates to a synergistic treatment strategy for enhancing the therapeutic efficacy of radiotherapy (RT) via nMOF-mediated drug delivery and RT enhancement. nMOF containing the high-Z element Hf and the ligand 1,4-dicarboxybenzene (Hf-BDC) was synthesized and loaded with two...
Published: 1/7/2020   |   Inventor(s): Conroy Sun, Allison DuRoss, Megan Neufeld
Keywords(s): Cancer, Radiation, Radiotherapy
Category(s): Therapeutics
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