Search Results - therapeutics

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Novel agents for the detection and treatment of bladder cancer.
Technology SummaryGiven the prevalence of bladder cancer in the United States, it is surprising that a limited number of treatments exist for this disease. To address this unmet need, researchers at Oregon Health & Science University have developed novel agents for use in both detecting and treating early stage, non-invasive bladder cancer. T...
Published: 9/5/2019   |   Inventor(s): John Muschler
Category(s): Biological Materials, Diagnostics, Imaging, Research Tools, Therapeutics
Allosteric Modulation of PARP1-DNA Binding with Small Molecule Inhibitors: A Potential None Synthetic Lethal Therapeutic Strategy for Treating Ewing Sarcoma and Other Solid Tumors
Allosteric Modulation of PARP1-DNA Binding with Small Molecule Inhibitors: A Potential None Synthetic Lethal Therapeutic Strategy for Treating Ewing Sarcoma and Other Solid TumorsOHSU Tech ID 2756Technology OverviewEwing sarcoma is the second most common type of bone cancer in children. Treatment options are limited to surgery and general chemother...
Published: 7/29/2019   |   Inventor(s): Moriah Arnold, Michael Cohen, Anang Shelat
Category(s): Therapeutics
Improved Cephalotaxine/Homoharringtonine Synthesis and New Anti-Cancer Compounds
Technology Description Oregon State University is seeking a licensee for an improved method to synthesize chemotherapeutic Homoharringtonine (HHT) that overcomes the need to use plant derived cephalotaxine. The synthetic method provides a high yield of chemically synthesized cephalotaxine as an HHT precursor and also enables the synthesis of novel...
Published: 6/14/2019   |   Inventor(s): Chris Beaudry, Xuan Ju
Category(s): Biological Materials, Chemical, Therapeutics
Photoreactor for Treatment of Jaundice
Technology Description Oregon State University is seeking a licensee or research collaborator for development or commercialization of a microfluidic visible light photoreactor for the treatment of jaundice in neonatal patients. The device enables safe extracorporeal blood treatment, making it an excellent replacement for equally effective, yet risk...
Published: 4/22/2019   |   Inventor(s): John Lahmann, Adam Higgins
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Bilirubin, Blood, hyperbilirubinemia, light, Medical Science & Technologies, Neonatal, Newborn, Photoreactor, Sepsis, treatment
Category(s): Medical Devices, Therapeutics, Engineering
A targeted therapy to treat HER-2 positive breast cancer
Technology SummaryA novel method of treatment has been identified by OHSU researchers that has the potential to effectively treat HER-2 positive breast cancer. The approach involves using an antibody that is capable of targeting a signaling molecule responsible for tumor growth. This novel targeted therapy in combination with chemotherapy can ben...
Published: 1/18/2019   |   Inventor(s): Shiuh-Wen Luoh
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
A therapeutic approach to minimize residual disease and relapse in cancer
Technology SummaryOHSU researchers have identified a novel treatment method which, when used in combination with first-line cancer therapies, has the potential to minimize residual disease, the primary cause of relapse in all cancers. The method leverages existing drugs that inhibit a metabolic target molecule not previously understood to be invol...
Published: 1/18/2019   |   Inventor(s): George Thomas, Hui-wen Lue, Jennifer Podolak, Kevin Kolahi
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
A Method For Extraction And Purification Of Chlorophylls For Large Scale Isolation From Spinach By Counter Current Chromatography
Technology Description This technology licensing opportunity provides improved methods for manufacturing and producing highly pure chlorophyll at high yields, from a variety of sources. Sources of chlorophyll useful with the patented methods include Spirulina pacifica, algae, spinach and alfalfa. The high yields and variety of sources provide a lo...
Published: 12/7/2018   |   Inventor(s): Carole Jubert, George Bailey, Jr.
Keywords(s): Agriculture, Biomedical, Biotechnology, Dyes and Colorants, Environmental Remediation, Food Science / Nutrition, Pharmaceuticals, Research Tools
Category(s): Agricultural, Chemical, Chemistry, Research Tools, Therapeutics
Inverse Micelle Preparation for Alginate-Based Drug Delivery Carriers
Technology Description Oregon State University is seeking a licensee or industry collaborator for development and commercialization of a novel method of inverse micelle preparation for alginate-based nanocarriers. The simple process takes only a few hours and can be completed at room temperature, overcoming the challenges common in the field regard...
Published: 10/31/2018   |   Inventor(s): Conroy Sun, Anna Brown, Justin Rosch
Keywords(s): alginate, Drug Delivery, inverse/reverse micelle, micelles
Category(s): Biological Materials, Chemical, Nanoscience & Microtechnologies, Therapeutics
Anticancer Compounds
Technology Description Oregon State University seeks a licensee or collaborative research and development partner to further develop and commercialize a family of newly identified anti-cancer compounds. All inquiries are welcome. Preclinical studies have demonstrated that these compounds are effective in inhibiting viability of Ewing's sarcoma cell...
Published: 5/2/2018   |   Inventor(s): Mark Leid, Elahe Esfandiari
Keywords(s): Cancer, Sarcoma, Tumor
Category(s): Therapeutics
Treatment for Muscle Atrophy and for Enhancing Muscle Growth
Technology Description This technology licensing and collaboration opportunity is for an mRNA based therapeutic that provides for increased hepatic production of follistatin (FS). In vivo experiments demonstrate delivered mRNA accumulates in the liver, which results in an increase of FS in blood serum. Mouse studies demonstrate a subcutaneous injec...
Published: 2/1/2018   |   Inventor(s): Oleh Taratula, Canan Schumann, Olena Taratula, Adam Alani
Keywords(s): atrophy, growth, mRNA carrier, mRNA delivery, muscle, Muscular Dystrophy, wasting
Category(s): Therapeutics
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