Search Results - therapeutics

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Selective PARP11 inhibitor for the treatment of cancer
​​​­Summary The current technology is a highly selective and potent inhibitor of PARP11 that could serve as an immuno-oncology therapeutic and enhance CAR-T cell therapies. Technology Overview Recent work identified PARP11 as a key component in driving tumor microenvironments (Nature Cancer, 2022), and suppression of PARP11 augmented the therapeutic...
Published: 9/19/2022   |   Inventor(s): Michael Cohen, Ilsa Kirby
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
Photoactivatable modulation of antibody binding
­ Summary The current technology involves a blocking construct that has the potential to increase antibody specificity and reduce unwanted off-target effects by modulating antibody activation in a manner that is predictable, reproducible and does not require genetic modification of the antibody sequence. Technology Overview Traditional antibodies...
Published: 1/4/2023   |   Inventor(s): Stuart Ibsen, Michael Brasino
Keywords(s): Diagnostics, Therapeutics
Category(s): Diagnostics, Therapeutics
Universal nanoprobes for imaging and treatment of cancer
Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection...
Published: 8/16/2022   |   Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Imaging, Therapeutics
Biological H2S / COS Donation by Thiocarbamates
­University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in...
Published: 5/2/2022   |   Inventor(s): Michael Pluth, Andrea Steiger, Yu Zhao
Keywords(s):  
Category(s): Chemistry, Physical Science, Therapeutics
Compounds for Thiol-Triggered COS and/or H2s Release and Methods of Making and Using the Same
University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in a class...
Published: 5/2/2022   |   Inventor(s): Michael Pluth, Yu Zhao, Matt Cerda
Keywords(s): Science
Category(s): Chemistry, Engineering, Medical Devices, Physical Science, Therapeutics
Thionoesters that Release H2S upon Thiol Ligation
University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in a class...
Published: 5/2/2022   |   Inventor(s): Michael Pluth, Matt Cerda
Keywords(s): Science
Category(s): Chemistry, Diagnostics, Medical Devices, Physical Science, Therapeutics
Gamma-ketothiocarbamate molecules that release COS
­University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in...
Published: 5/2/2022   |   Inventor(s): Michael Pluth, Yu Zhao
Keywords(s):  
Category(s): Chemistry, Diagnostics, Engineering, Medical Devices, Physical Science, Research Tools, Therapeutics
SARS-CoV-2 single domain antibody (nanobody) for the treatment of COVID-19
Summary Oregon Health & Science University researchers have developed a highly potent SARS-CoV-2 neutralizing antibody that is effective against multiple variants and is highly stable, which could make it easy to store and transport. Technology Overview Nanobodies are functional single-domain antibodies from camelid species that offer several...
Published: 5/25/2022   |   Inventor(s): Fikadu Tafesse, Jules Weinstein, Timothy Bates
Keywords(s): COVID-19 Technologies, COVID-19 Technologies - Projects, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics
SpdE, a novel amino acid-sensing diguanylate cyclase
SpdE, a novel amino acid-sensing diguanylate cyclase Tech ID UO-19-33 Animals are colonized by dynamic communities of bacteria, largely acquired by transmission from the external environment and other hosts; however, the traits that promote a microbe’s ability to be host-associated (i.e. to colonize or otherwise exist within a host) are not...
Published: 1/25/2023   |   Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson
Keywords(s): Science
Category(s): Diagnostics, Research Tools, Therapeutics
Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation
HEADLINE: Novel protein induces pancreatic beta cell proliferation, is ideal for diabetes treatment research Our scientists discovered a novel protein that offers a potential new avenue of research for labs developing drugs to treat diabetes. The newly-discovered BefA (β Cell Expansion Factor A) protein acts to increase total pancreatic...
Published: 5/2/2022   |   Inventor(s): Karen Guillemin, Jennifer Hampton
Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish
Category(s): Diagnostics, Therapeutics, Research Tools
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