Search Results - therapeutics

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Malassezia-Secreted Factor with Antibiotic Activity

1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...

Published: 1/8/2026 | Inventor(s): Matthew Barber, Caitlin Kowalski

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Category(s): Therapeutics, Diagnostics, Research Tools

Moderate-Affinity Affibodies for Controlled Protein Delivery and Bioactivity

1. Technology Overview The invention introduces a novel method for controlled protein delivery and bioactivity using moderate-affinity affibodies. These 58-amino acid peptides can specifically bind to various proteins, allowing for the controlled release or sequestration of multiple payloads within a single vehicle. The technology leverages the conjugation...

Published: 1/8/2026 | Inventor(s): Marian Hettiaratchi, Henry Hochstatter, Veronica Spaulding, Jonathan Dorogin, Alycia Galindo, Chandler Asnes, Madeline Martin, Justin Svendsen

Keywords(s):

Category(s): Medical Devices, Therapeutics, Materials Science

Anisotropic Poly(ethylene glycol)-Based Hydrogels Synthesized via Two-Stage Polymerization and Mechanical Alignment

1. Technology Overview The invention introduces synthetic poly(ethylene glycol)-based hydrogels with anisotropic polymer network topology, mimicking the structure of musculoskeletal tissues. These hydrogels are synthesized using a two-stage polymerization process, allowing for the application of mechanical force to impart anisotropy. The technology...

Published: 1/2/2026 | Inventor(s): Danielle Benoit, Tayler Hebner

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Category(s): Chemistry, Therapeutics

A photocrosslinkable bone derived biomaterial for tissue engineering applications

Summary Demineralized bone matrix has been widely used in the clinic to heal bone injuries due to its remarkable regenerative properties. However, this is not a material that can be synthesized in large batches, with highly reproducible chemistry, and cannot be set/polymerized in-situ for precise adaptation. BoneMA is photopolymerizable material that...

Published: 7/23/2025 | Inventor(s): Luiz Bertassoni, Avathamsa Athirasala

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Category(s): Therapeutics, Device

Phage Bank for Selection of Personalized Therapeutic Treatments against Mycobacteria

A phage bank comprising lytic phages against mycobacteria, used to create phage cocktails for treatment of drug-resistant infections Background Non‑tuberculous mycobacteria (NTM) pathogens are extremely antibiotic resistant causing the most difficult-to-treat pulmonary infections in immunocompromised individuals such are cystic fibrosis (CF), bronchiectasis,...

Published: 8/4/2025 | Inventor(s): Lia Danelishvili

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Category(s): Biological Materials, Therapeutics

Selective Modulators of Ah-R to Treat Cancer

Synergistic compositions and method of using modulators of Ah-R activity and synergistic compounds to treat cancer Background Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. When activated by the binding of a wide range of both endogenous and exogenous small molecules, AhR signaling influences cellular outcomes in different...

Published: 8/4/2025 | Inventor(s): Siva Kolluri, Bach Nguyen, Daniel Elson

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Category(s): Therapeutics

Malaria transmission blocking using ELQ-infused bed nets

Summary Insecticide-treated mosquito bed nets reduce the transmission of malaria, but mosquitos have developed resistance to insecticides leading to reduced efficacy. Our new technology is a chemical solution for mosquito nets that kills malaria, is less prone to drug-resistance and is not toxic to humans. Technology Overview Insecticide-treated...

Published: 10/15/2024 | Inventor(s): Michael Riscoe, Aaron Nilsen, Joseph (Stone) Doggett, Flaminia Catteruccia, Douglas (Doug) Paton

Keywords(s): Therapeutics, Therapeutics - Infectious Diseases, Therapeutics - Other

Category(s): Therapeutics, Device, Chemical

Enhancing Methotrexate Efficacy for Ectopic Pregnancy Treatment

Methotrexate (MTX) loaded polymersomes are used to preferentially deliver MTX to sites of ectopic pregnancy Background Ectopic pregnancy, abnormal pregnancy implantation at sites other than in the uterine cavity, leads to internal bleeding if not identified and treated in a timely manner, and is a major cause of maternal morbidity and mortality....

Published: 8/4/2025 | Inventor(s): Olena Taratula, Oleh Taratula, Maureen Baldwin, Leslie Myatt, Babak Mamnoon

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Category(s): Therapeutics

Combination therapy for the treatment of triple negative breast cancer

Summary Researchers at OHSU have discovered a novel combination therapy for triple negative breast cancer, which increases immune responses, causes tumor regression and improves survival in animal models. Technology Overview Triple negative breast cancer (TNBC) represents one of the most aggressive forms of all breast cancer subtypes with a very...

Published: 9/17/2024 | Inventor(s): Sanjay Malhotra, Lisa Coussens, Dhanir Tailor, Sushil Kumar, Arpit Dheeraj

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Inhibitors of cancer-mediated bone destruction

Summary Current drugs for bone metastases merely prevent and slow the breakdown of bone, but are ineffective in slowing the spread of cancer. The current technology is a dual-acting bone defender (DABD), which acts to prevent bone destruction while simultaneously attacking cancer’s ability to spread. Technology Overview In many cancers, especially...

Published: 1/2/2025 | Inventor(s): Raymond Bergan, Ryan Gordon, Abhinandan Pattanayak

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

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