Search Results - therapeutics

57 Results Sort By:
A strong mini-promoter for AAV
SummaryViral mediated transgene delivery often utilizes specialized promoters that drive ubiquitous expression; however, these promoters are large and limit the amount of remaining space in AAV vectors for the transgene. The laboratory of Dr. Markus Grompe at OHSU has identified a novel promoter, which drives strong expression in multiple cell types...
Published: 10/9/2020   |   Inventor(s): Markus Grompe, Sunghee Chai
Keywords(s): Biological Materials, Therapeutics
Category(s): Biological Materials, Therapeutics
siRNA sequence and method for treating dengue virus infection
siRNA sequence and method for treating dengue virus infection OHSU Technology 1601 Value Proposition: Dengue virus (DENV) is a leading cause of illness in the tropics and subtropics, with as many as 100 million people infected yearly. Currently, there is no approved vaccine for DENV or any approved antiviral compositions to treat DENV either...
Published: 9/16/2020   |   Inventor(s): David Stein, Klaus Frueh, Stuart Perry, Sujan Shresta
Keywords(s): Research Tools - Reagents, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Research Tools
Antiviral Drug Discovery for AIDS: The HIV-1 Vif Protein
Technology OverviewDespite remarkable medical advances, the incidence of HIV infections continues to rise throughout the world. The majority of current HIV therapies target HIV reverse transcriptase or protease, but viral resistance and toxicity have created a need for more potent and safer therapies against different viral targets. Virion infectivity...
Published: 9/16/2020   |   Inventor(s): David Kabat, Mariana Marin, Susan Kozak, Kristine Rose
Keywords(s): Research Tools - Screening, Therapeutics - Infectious Diseases
Category(s): Therapeutics
Thyronamines: novel bioactive metabolites of thyroid hormone
NOVEL BIOACTIVE METABOLITES OF THYROID HORMONE: A SAFE AND EFFECTIVE TREATMENT FOR DISEASEOHSU Technology 0674Researchers at Oregon Health & Science University and University of California, San Francisco discovered and validated a new class of thyroid hormone metabolites. The most potent of these, 3-iodothyronamine, has been shown in animal studies...
Published: 9/16/2020   |   Inventor(s): Thomas Scanlan, David Grandy, James Bunzow, Katherine Suchland, Matthew Hart, Edwin Tan, Mononori Miyakawa
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Endocrine
Category(s): Therapeutics
Antisense Therapeutic Agents for Treatment of Covid-19
Technology Description This technology licensing opportunity relates to antisense agent compounds for treating or preventing a SARS-CoV-2 infection. A key feature of this technology is unique cell penetrating peptide and antisense oligomer (CPP-PMO) combinations that provide improved antiviral efficacy and reduced cytotoxicity. The compounds are oligomers...
Published: 9/9/2020   |   Inventor(s): David Stein, Hong Moulton, Kyle Rosenke, Heinrich Feldmann
Keywords(s): antisense, coronavirus, covid-19, Drug, SARS-CoV-2, Therapeutic
Category(s): Therapeutics
Small molecule modulators of PTP sigma for nerve regeneration
Researchers at Oregon Health & Science discovered novel compounds that promote nerve regeneration in tissues that otherwise prevent neural growth due to scarring. Nerve injury is a major source of morbidity in the military whether from traumatic brain injury, spinal cord injury, or an extremity injury damaging peripheral nerves. The etiologies of...
Published: 8/31/2020   |   Inventor(s): Michael Cohen, Beth Habecker, Haihong Jin, Ryan Gardner, Matthew Blake
Keywords(s): Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
Adaptive Exercise-Enabled Proportional-Derivative Artificial Pancreas Control Algorithm
This is an adaptive proportional-derivative (APD) control algorithm that provides automated delivery amounts of insulin and optionally glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. The APD algorithm includes a safety layer decision tree to prevent dosing of...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Adaptive Exercise-Enabled Model-Predictive-Control Artificial Pancreas Control Algorithm
This is a model-predictive control (MPC) algorithm that provides automated delivery amounts of insulin and, optionally, glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. Dosing insulin after meals can be challenging and can lead to hyperglycemia or late-term hypoglycemia...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Method of Producing Human Pluripotent Stem Cells by Somatic Cell Nuclear Transfer
This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). PSC’s only naturally exist in early human embryos. Methods are described to produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin cells as a starting point. Human PSC’s...
Published: 8/5/2020   |   Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana
Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
1 2 3 4 5 6 
© 2020. All Rights Reserved. Powered by Inteum