Search Results - therapeutics

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Inhibitors of cancer-mediated bone destruction

Summary Current drugs for bone metastases merely prevent and slow the breakdown of bone, but are ineffective in slowing the spread of cancer. The current technology is a dual-acting bone defender (DABD), which acts to prevent bone destruction while simultaneously attacking cancer’s ability to spread. Technology Overview In many cancers, especially...

Published: 5/20/2024 | Inventor(s): Raymond Bergan, Ryan Gordon, Abhinandan Pattanayak

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Covalent inhibitors of PARP-16 for cancer treatment

Summary The current technology is a selective, covalent inhibitor of PARP16 with potential therapeutic applications for the treatment of cancer. Technology Overview The poly-ADP-ribose-polymerase (PARP) family is made up of 17 enzymes in humans that are increasingly recognized as major downstream regulators of NAD+-mediated signaling in cells. PARP1...

Published: 2/12/2024 | Inventor(s): Michael Cohen, Daniel Bejan, Sunil Sundalam

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

CD74 as a biomarker and therapeutic target for familial platelet (FPD) disorder

Summary Research at OHSU has identified the CD74 signaling cascade as a potential therapeutic target and diagnostic biomarker for RUNX1-mutated familial platelet disorder (FPD), which is a premalignant condition for acute myeloid leukemia. Technology Overview Current estimates suggest as many as 18,000 people may be living with RUNX1-FPD in the United...

Published: 2/27/2024 | Inventor(s): Anupriya Agarwal, Mona Mohammadhosseini

Keywords(s): Diagnostics, Diagnostics - Cancer, Diagnostics - Other, Therapeutics, Therapeutics - Cancer, Therapeutics - Other

Category(s): Diagnostics, Therapeutics

Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin

Background The emerging and persistent threat of multidrug-resistant bacterial infections has resulted in enormous healthcare costs and poses major challenges to public health. To address the need for new antibiotics capable of combating the gowning problem of resistance, Oregon State University researchers cloned and patented the biosynthetic gene...

Published: 6/17/2024 | Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

Nanoparticle ultrasound contrast agents with high acoustic activity

Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...

Published: 11/22/2023 | Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics

Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics

A method of enhancing cancer immunotherapies through androgen receptor modulation

Summary The current technology has the potential to enhance the effectiveness of checkpoint blockade for advanced prostate cancer patients by directly enhancing T cell function through a reduction in intrinsic androgen receptor signaling. Technology Overview In many patients with advanced cancer, immunotherapy treatments have largely failed....

Published: 9/27/2023 | Inventor(s): Fanny Polesso, Amy Moran

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Selective PARP11 inhibitor for the treatment of cancer

Summary The current technology is a highly selective and potent inhibitor of PARP11 that could serve as an immuno-oncology therapeutic and enhance CAR-T cell therapies. Technology Overview Recent work identified PARP11 as a key component in driving tumor microenvironments (Nature Cancer, 2022), and suppression of PARP11 augmented the therapeutic...

Published: 4/29/2024 | Inventor(s): Michael Cohen, Ilsa Kirby

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Photoactivatable modulation of antibody binding

Summary The current technology involves a blocking construct that has the potential to increase antibody specificity and reduce unwanted off-target effects by modulating antibody activation in a manner that is predictable, reproducible and does not require genetic modification of the antibody sequence. Technology Overview Traditional antibodies...

Published: 9/21/2023 | Inventor(s): Stuart Ibsen, Michael Brasino

Keywords(s): Diagnostics, Therapeutics

Category(s): Diagnostics, Therapeutics

Universal nanoprobes for imaging and treatment of cancer

Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection and...

Published: 9/21/2023 | Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer

Category(s): Diagnostics, Imaging, Therapeutics

Biological H2S / COS Donation by Thiocarbamates

University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in...

Published: 5/2/2022 | Inventor(s): Michael Pluth, Andrea Steiger, Yu Zhao

Keywords(s):

Category(s): Chemistry, Physical Science, Therapeutics

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