Search Results - therapeutics

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Treatment for Hypertension
Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...
Published: 1/7/2020   |   Inventor(s): Patrick Iversen, Andrew Annalora
Keywords(s): Hypertension, Pharmaceuticals, Transplantation
Category(s): Therapeutics
Enhancing Radiation for Treatment of Cancer
Technology Description This licensing and collaborative research opportunity relates to a synergistic treatment strategy for enhancing the therapeutic efficacy of radiotherapy (RT) via nMOF-mediated drug delivery and RT enhancement. nMOF containing the high-Z element Hf and the ligand 1,4-dicarboxybenzene (Hf-BDC) was synthesized and loaded with two...
Published: 1/7/2020   |   Inventor(s): Conroy Sun, Allison DuRoss, Megan Neufeld
Keywords(s): Cancer, Radiation, Radiotherapy
Category(s): Therapeutics
Novel agents for the detection and treatment of bladder cancer.
Technology SummaryGiven the prevalence of bladder cancer in the United States, it is surprising that a limited number of treatments exist for this disease.  To address this unmet need, researchers at Oregon Health & Science University have developed novel agents for use in both detecting and treating early stage, non-invasive bladder cancer.  Technology...
Published: 9/5/2019   |   Inventor(s): John Muschler
Category(s): Biological Materials, Diagnostics, Imaging, Research Tools, Therapeutics
Allosteric Modulation of PARP1-DNA Binding with Small Molecule Inhibitors: A Potential None Synthetic Lethal Therapeutic Strategy for Treating Ewing Sarcoma and Other Solid Tumors
Allosteric Modulation of PARP1-DNA Binding with Small Molecule Inhibitors: A Potential None Synthetic Lethal Therapeutic Strategy for Treating Ewing Sarcoma and Other Solid TumorsOHSU Tech ID 2756Technology OverviewEwing sarcoma is the second most common type of bone cancer in children. Treatment options are limited to surgery and general chemotherapy;...
Published: 7/29/2019   |   Inventor(s): Moriah Arnold, Michael Cohen, Anang Shelat
Category(s): Therapeutics
Improved Cephalotaxine/Homoharringtonine Synthesis and New Anti-Cancer Compounds
Technology Description Oregon State University is seeking a licensee for an improved method to synthesize chemotherapeutic Homoharringtonine (HHT) that overcomes the need to use plant derived cephalotaxine. The synthetic method provides a high yield of chemically synthesized cephalotaxine as an HHT precursor and also enables the synthesis of novel...
Published: 6/14/2019   |   Inventor(s): Chris Beaudry, Xuan Ju
Category(s): Biological Materials, Chemical, Therapeutics
Photoreactor for Treatment of Jaundice
Technology Description Oregon State University is seeking a licensee or research collaborator for development or commercialization of a microfluidic visible light photoreactor for the treatment of jaundice in neonatal patients. The device enables safe extracorporeal blood treatment, making it an excellent replacement for equally effective, yet risky,...
Published: 4/22/2019   |   Inventor(s): John Lahmann, Adam Higgins
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Bilirubin, Blood, hyperbilirubinemia, light, Medical Science & Technologies, Neonatal, Newborn, Photoreactor, Sepsis, treatment
Category(s): Medical Devices, Therapeutics, Engineering
A targeted therapy to treat HER-2 positive breast cancer
Technology SummaryA novel method of treatment has been identified by OHSU researchers that has the potential to effectively treat HER-2 positive breast cancer.  The approach involves using an antibody that is capable of targeting a signaling molecule responsible for tumor growth.  This novel targeted therapy in combination with chemotherapy can benefit...
Published: 1/18/2019   |   Inventor(s): Shiuh-Wen Luoh
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
A therapeutic approach to minimize residual disease and relapse in cancer
Technology SummaryOHSU researchers have identified a novel treatment method which, when used in combination with first-line cancer therapies, has the potential to minimize residual disease, the primary cause of relapse in all cancers.  The method leverages existing drugs that inhibit a metabolic target molecule not previously understood to be involved...
Published: 1/18/2019   |   Inventor(s): George Thomas, Hui-wen Lue, Jennifer Podolak, Kevin Kolahi
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
A Method For Extraction And Purification Of Chlorophylls For Large Scale Isolation From Spinach By Counter Current Chromatography
Technology Description This technology licensing opportunity provides improved methods for manufacturing and producing highly pure chlorophyll at high yields, from a variety of sources. Sources of chlorophyll useful with the patented methods include Spirulina pacifica, algae, spinach and alfalfa. The high yields and variety of sources provide a low...
Published: 12/7/2018   |   Inventor(s): Carole Jubert, George Bailey, Jr.
Keywords(s): Agriculture, Biomedical, Biotechnology, Dyes and Colorants, Environmental Remediation, Food Science / Nutrition, Pharmaceuticals, Research Tools
Category(s): Agricultural, Chemical, Chemistry, Research Tools, Therapeutics
Anticancer Compounds
Technology Description Oregon State University seeks a licensee or collaborative research and development partner to further develop and commercialize a family of newly identified anti-cancer compounds. All inquiries are welcome. Preclinical studies have demonstrated that these compounds are effective in inhibiting viability of Ewing's sarcoma cell...
Published: 5/2/2018   |   Inventor(s): Mark Leid, Elahe Esfandiari
Keywords(s): Cancer, Sarcoma, Tumor
Category(s): Therapeutics
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