Search Results - diagnostics+-+cancer

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Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Mutation-Specific Treatment Strategies for Acute Myeloid Leukemia
Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics, Diagnostics
Rat monoclonal antibody to pS62-MYC
Summary MYC is a proto-oncogene associated with tumor pathogenesis in multiple cancer types, but currently there is a lack of reliable antibodies to assess MYC levels in FFPE patient samples. OHSU researchers have developed a rat monoclonal Serine 62 phosphorylated MYC antibody, which recognizes a form of MYC associated with increased protein stability...
Published: 4/13/2021   |   Inventor(s): Rosalie Sears, Colin Daniel
Keywords(s): Biological Materials, Biological Materials - Antibodies, Diagnostics - Cancer, Research Tools
Category(s): Biological Materials, Research Tools
Nanoparticle ultrasound contrast agents with high acoustic activity
SummaryContrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 2/24/2021   |   Inventor(s): Adem Yildirim, Jose Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
Novel albumin binder for improving the targeting efficacy of diagnostic or therapeutic reagents
Technology Summary Albumin binders have been developed to improve tumor uptake of therapeutic radioisotopes (radiopeptides) by prolonging radiopeptide blood circulation. However, use of these albumin binders also results in an increased uptake of radiopeptide in healthy organs, negating the benefits of the treatment. Researchers at Oregon Health...
Published: 1/28/2021   |   Inventor(s): Dexing Zeng, Lingyi Sun, Zhonghan Li
Keywords(s): Diagnostics - Cancer, Imaging, Therapeutics - Cancer
Category(s): Therapeutics, Chemical, Imaging
Algorithm For Automated Detection of Melanoma
Technology Overview Comprehensive diagnosis of melanoma typically requires both reliable histopathology and the trained eye of a clinician for assessment. With optical (as opposed to physical) sectioning of tissue and OHSU created software to process confocal images, it is possible to distinguish the diagnostic traits of malignancy, such as the presence...
Published: 11/9/2017   |   Inventor(s): Daniel Gareau, Ricky Hennessy, Steven Jacques
Keywords(s): Device, Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software
Category(s): Diagnostics
MicroRNA inhibitors to enhance radiotherapy efficacy
Almost 50% of cancer patients undergo some form of radiotherapy; however only half of these patients have a significant response to this treatment. Higher doses of radiation can be effective, but often result in damage to nearby healthy organs. One approach to increase radiotherapy sensitivity of the targeted tissue is to enhance the efficacy of lower/normal...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Shushan Rana, Charles Thomas
Keywords(s): Diagnostics - Cancer, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
RNA biomarkers for predicting radiotherapy effectiveness
SummaryRNA signature that can differentiate between colorectal cancer patients having a partial or no response to radiation therapy. This signature can also be used as a biomarker to predict which patients will respond to standard-of-care radiation therapy, enabling the clinical management of the non-responding patient to encompass alternative neoadjuvant...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Vassiliki (liana) Tsikitis
Keywords(s): Diagnostics - Cancer
Category(s): Diagnostics
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