Search Results - diagnostics+-+cancer

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High-throughput precision medicine screening for solid tumors
Summary The current technology provides a unique ex vivo biopsy culture method for improved and personalized screening of multiple drug combinations for solid tumors. Technology Overview Precision medicine allows for cancer therapies to be tailored to individual tumor characteristics, but current screening methods often lack the capacity to 1) capture...
Published: 12/2/2022   |   Inventor(s): Joe Gray, Zuzana Tatarova, Oliver Jonas
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Software for deep learning-based inference of biomarker distribution in cancer samples
Summary Multiplexed tissue imaging (MTI) is a powerful tool for cancer pathology, but it is also expensive, which has limited its availability for underserved communities, particularly in the developing world. The current software uses hematoxylin & eosin (H&E) staining, which is more widely available, to predict oncology biomarker distribution,...
Published: 12/2/2022   |   Inventor(s): Young Hwan Chang, Erik Burlingame, Geoffrey Schau, Elliot Gray
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Diagnostics, Software
Universal nanoprobes for imaging and treatment of cancer
Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection...
Published: 8/16/2022   |   Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Imaging, Therapeutics
Label-free microfluidic device for cancer liquid biopsy
Summary Liquid biopsies offer a less invasive method of early cancer detection; however, circulating cancer cells are rare and difficult to detect. The current technology is a device that allows for sensitive, label-free enrichment of circulating neoplastic cells in order to facilitate the detection of cancer biomarkers from peripheral blood samples. Technology...
Published: 8/16/2022   |   Inventor(s): Yu-Jui (Roger) Chiu, Ajay Sapre, Jose Luis Montoya Mira, Kyle Gustafson
Keywords(s): Device, Device - Other, Diagnostics, Diagnostics - Cancer, Research Tools
Category(s): Diagnostics, Research Tools, Device
Cell-free RNA biomarkers capable of distinguishing cancer from premalignant disease
Summary Early cancer detection is critical for improving long-term patient survival and highlights a need for new sensitive and minimally-invasive early detection methods. The current technology includes novel sets of cell-free RNA biomarkers that can be used to potentially distinguish between malignant and pre-malignant forms of certain cancers using...
Published: 6/15/2022   |   Inventor(s): Thuy Ngo, Hyun Kim, Josiah Wagner, Breeshey Roskams-Hieter, Pavana Anur
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Mutation-specific treatment strategies for acute myeloid leukemia
Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...
Published: 10/3/2022   |   Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics, Diagnostics
Rat monoclonal antibody to pS62-MYC
Summary MYC is a proto-oncogene associated with tumor pathogenesis in multiple cancer types, but currently there is a lack of reliable antibodies to assess MYC levels in FFPE patient samples. OHSU researchers have developed a rat monoclonal Serine 62 phosphorylated MYC antibody, which recognizes a form of MYC associated with increased protein stability...
Published: 6/30/2021   |   Inventor(s): Rosalie Sears, Colin Daniel
Keywords(s): Biological Materials, Biological Materials - Antibodies, Diagnostics - Cancer, Research Tools
Category(s): Biological Materials, Research Tools
Novel albumin binder for improving the targeting efficacy of diagnostic or therapeutic reagents
Summary Albumin binders have been developed to improve tumor uptake of therapeutic radioisotopes (radiopeptides) by prolonging radiopeptide blood circulation. However, use of these albumin binders also results in an increased uptake of radiopeptide in healthy organs, negating the benefits of the treatment. Researchers at Oregon Health & Science...
Published: 10/3/2022   |   Inventor(s): Dexing Zeng, Lingyi Sun, Zhonghan Li
Keywords(s): Diagnostics - Cancer, Imaging, Therapeutics - Cancer
Category(s): Therapeutics, Chemical, Imaging
Algorithm For Automated Detection of Melanoma
Summary Incidence of malignant melanoma (MM) are increasing in the United States, and early detection and excision are critical due to the high tendency for MMs to metastasize. Oregon Health & Science University researchers have developed an automated cellular quantification software for use with reflectance confocal microscopy that could increase...
Published: 9/21/2022   |   Inventor(s): Daniel Gareau, Ricky Hennessy, Steven Jacques
Keywords(s): Device, Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software
Category(s): Diagnostics
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