Search Results - diagnostics+-+cancer

14 Results Sort By:
CD74 as a biomarker and therapeutic target for familial platelet (FPD) disorder
Summary Research at OHSU has identified the CD74 signaling cascade as a potential therapeutic target and diagnostic biomarker for RUNX1-mutated familial platelet disorder (FPD), which is a premalignant condition for acute myeloid leukemia. Technology Overview Current estimates suggest as many as 18,000 people may be living with RUNX1-FPD in the United...
Published: 2/27/2024   |   Inventor(s): Anupriya Agarwal, Mona Mohammadhosseini
Keywords(s): Diagnostics, Diagnostics - Cancer, Diagnostics - Other, Therapeutics, Therapeutics - Cancer, Therapeutics - Other
Category(s): Diagnostics, Therapeutics
Nanoparticle ultrasound contrast agents with high acoustic activity
Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 11/22/2023   |   Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
Novel single-gene biomarker for acute myeloid leukemia prognosis
Summary The current technology is a novel set of biomarkers derived from the largest ever genomic and transcriptomic data set for acute myeloid leukemia (AML), which includes a novel single gene biomarker capable of strongly predicting AML prognosis. Technology Overview Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with an incidence...
Published: 9/27/2023   |   Inventor(s): Daniel Bottomly, Brian Druker, Kara Johnson, Stephen (Steve) Kurtz, Nicola Long, Shannon McWeeney, Anna Reister Schultz, Cristina Tognon, Jeffrey (Jeff) Tyner
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Effective combinations of targeted agents for hematologic malignancies
Summary Current treatment strategies for acute myeloid leukemia (AML) have low efficacy rates, due in part to the complex and heterogenous underlying genetics of this cancer. Oregon Health & Science University researchers have developed a precision medicine approach for the treatment of AML by identifying an effective combination therapy for a specific...
Published: 9/27/2023   |   Inventor(s): Jeffrey (Jeff) Tyner, Elie Traer, Stephen (Steve) Kurtz, Brian Druker, Andrew Kaempf, Christopher (Chris) Eide, Motomi (Tomi) Mori
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
High-throughput precision medicine screening for solid tumors
Summary The current technology provides a unique ex vivo biopsy culture method for improved and personalized screening of multiple drug combinations for solid tumors. Technology Overview Precision medicine allows for cancer therapies to be tailored to individual tumor characteristics, but current screening methods often lack the capacity to 1) capture...
Published: 9/27/2023   |   Inventor(s): Joe Gray, Zuzana Tatarova, Oliver Jonas
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Software for deep learning-based inference of biomarker distribution in cancer samples
Summary Multiplexed tissue imaging (MTI) is a powerful tool for cancer pathology, but it is also expensive, which has limited its availability for underserved communities, particularly in the developing world. The current software uses hematoxylin & eosin (H&E) staining, which is more widely available, to predict oncology biomarker distribution,...
Published: 9/27/2023   |   Inventor(s): Young Hwan Chang, Erik Burlingame, Geoffrey Schau, Elliot Gray
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Diagnostics, Software
Universal nanoprobes for imaging and treatment of cancer
Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection and...
Published: 9/21/2023   |   Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Imaging, Therapeutics
Label-free microfluidic device for cancer liquid biopsy
Summary Liquid biopsies offer a less invasive method of early cancer detection; however, circulating cancer cells are rare and difficult to detect. The current technology is a device that allows for sensitive, label-free enrichment of circulating neoplastic cells in order to facilitate the detection of cancer biomarkers from peripheral blood samples. Technology...
Published: 8/16/2022   |   Inventor(s): Yu-Jui (Roger) Chiu, Ajay Sapre, Jose Luis Montoya Mira, Kyle Gustafson
Keywords(s): Device, Device - Other, Diagnostics, Diagnostics - Cancer, Research Tools
Category(s): Diagnostics, Research Tools, Device
Cell-free RNA biomarkers capable of distinguishing cancer from premalignant disease
Summary Early cancer detection is critical for improving long-term patient survival and highlights a need for new sensitive and minimally-invasive early detection methods. The current technology includes novel sets of cell-free RNA biomarkers that can be used to potentially distinguish between malignant and pre-malignant forms of certain cancers using...
Published: 6/15/2022   |   Inventor(s): Thuy Ngo, Hyun Kim, Josiah Wagner, Breeshey Roskams-Hieter, Pavana Anur
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 9/19/2023   |   Inventor(s): Jeffrey (Jeff) Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher (Chris) Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
1 2 
© 2024. All Rights Reserved. Powered by Inteum