Search Results - diagnostics - cancer

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Algorithm For Automated Detection of Melanoma
Technology Overview Comprehensive diagnosis of melanoma typically requires both reliable histopathology and the trained eye of a clinician for assessment. With optical (as opposed to physical) sectioning of tissue and OHSU created software to process confocal images, it is possible to distinguish the diagnostic traits of malignancy, such as the...
Published: 11/9/2017   |   Inventor(s): Daniel Gareau, Ricky Hennessy, Steven Jacques
Keywords(s): Device, Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software
Category(s): Diagnostics
Novel activating NTRK2 and NTRK3 mutations as biomarkers for NTRK inhibitor sensitivity in cancer
Neurotrophic receptor tyrosine kinases (NTRK) are a family of genes involved in neuronal development. Mutations in these proteins result in dysregulation of neurons and may increase the risk of disease. NTRK gene fusions have previously been implicated as oncogenic drivers in various solid tumors. Researchers at OHSU have now identified four novel ...
Published: 7/3/2017   |   Inventor(s): Cristina Tognon, Monika Davare, Kristin Qian, Brian Druker
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Oncogenic CSF3R Mutations in Neutrophilic Leukemia
Atypical chronic myelogenous leukemia (aCML) and chronic neutrophilic leukemia (CNL) are rare blood cancers with poor prognoses and no standard of care exists for these disorders. Patients are typically diagnosed using histological and cytogenetic techniques and few recurrent genetic mutations are associated with these disorders. OHSU investigato...
Published: 6/15/2017   |   Inventor(s): Jeffrey Tyner, Julia Maxson, Brian Druker
Keywords(s): Diagnostics - Cancer
Category(s): Diagnostics
MicroRNA inhibitors to enhance radiotherapy efficacy
Almost 50% of cancer patients undergo some form of radiotherapy; however only half of these patients have a significant response to this treatment. Higher doses of radiation can be effective, but often result in damage to nearby healthy organs. One approach to increase radiotherapy sensitivity of the targeted tissue is to enhance the efficacy of l...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Shushan Rana, Charles Thomas
Keywords(s): Diagnostics - Cancer, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
RNA biomarkers for predicting radiotherapy effectiveness
The standard of care for patients with a diagnosis of colorectal cancer is radiation therapy to reduce tumor size, followed by surgery. However, colorectal cancer patients do not respond equally to radiation therapy. Researchers at OHSU have identified an RNA signature comprised of a microRNA and 4 target genes (mRNAs) that can differentiate betwe...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Vassiliki (liana) Tsikitis
Keywords(s): Diagnostics - Cancer
Category(s): Diagnostics
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