Search Results - therapeutics+-+cancer

14 Results

Sort By:

Covalent inhibitors of PARP-16 for cancer treatment

Summary The current technology is a selective, covalent inhibitor of PARP16 with potential therapeutic applications for the treatment of cancer. Technology Overview The poly-ADP-ribose-polymerase (PARP) family is made up of 17 enzymes in humans that are increasingly recognized as major downstream regulators of NAD+-mediated signaling in cells. PARP1...

Published: 2/12/2024 | Inventor(s): Michael Cohen, Daniel Bejan, Sunil Sundalam

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

CD74 as a biomarker and therapeutic target for familial platelet (FPD) disorder

Summary Research at OHSU has identified the CD74 signaling cascade as a potential therapeutic target and diagnostic biomarker for RUNX1-mutated familial platelet disorder (FPD), which is a premalignant condition for acute myeloid leukemia. Technology Overview Current estimates suggest as many as 18,000 people may be living with RUNX1-FPD in the United...

Published: 2/27/2024 | Inventor(s): Anupriya Agarwal, Mona Mohammadhosseini

Keywords(s): Diagnostics, Diagnostics - Cancer, Diagnostics - Other, Therapeutics, Therapeutics - Cancer, Therapeutics - Other

Category(s): Diagnostics, Therapeutics

A method of enhancing cancer immunotherapies through androgen receptor modulation

Summary The current technology has the potential to enhance the effectiveness of checkpoint blockade for advanced prostate cancer patients by directly enhancing T cell function through a reduction in intrinsic androgen receptor signaling. Technology Overview In many patients with advanced cancer, immunotherapy treatments have largely failed....

Published: 9/27/2023 | Inventor(s): Fanny Polesso, Amy Moran

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Selective PARP11 inhibitor for the treatment of cancer

Summary The current technology is a highly selective and potent inhibitor of PARP11 that could serve as an immuno-oncology therapeutic and enhance CAR-T cell therapies. Technology Overview Recent work identified PARP11 as a key component in driving tumor microenvironments (Nature Cancer, 2022), and suppression of PARP11 augmented the therapeutic...

Published: 11/6/2023 | Inventor(s): Michael Cohen, Ilsa Kirby

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Universal nanoprobes for imaging and treatment of cancer

Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection and...

Published: 9/21/2023 | Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer

Category(s): Diagnostics, Imaging, Therapeutics

Methods of treating venetoclax-resistant acute myeloid leukemia

SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...

Published: 9/19/2023 | Inventor(s): Jeffrey (Jeff) Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher (Chris) Eide, Ravindra Majeti

Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer

Category(s): Diagnostics, Therapeutics

Mutation-specific treatment strategies for acute myeloid leukemia

Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...

Published: 10/3/2022 | Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney

Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics, Diagnostics

Anti-cancer compounds with improved cardiac safety and drug resistance profiles

Summary Tyrosine kinase inhibitors are effective targeted anti-cancer therapeutics, but currently available inhibitors have limitations due to drug resistance and cardiotoxic effects. Oregon Health & Science University researchers have developed a class of kinase inhibitors with an improved cardiovascular safety profile and the potential to overcome...

Published: 9/21/2023 | Inventor(s): Sanjay Malhotra, Mallesh Pandrala, Dhanir Tailor, Mark Mercola, Arne Antoon Bruyneel

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Radiation-enhanced delivery of antisense oligonucleotides against MGMT

Summary MGMT is a critical enzyme driving DNA repair, and down-regulation of this molecule in tumors is linked to increased efficacy of cancer therapies that promote DNA damage and apoptosis of cancer cells. Researchers at the Veteran’s Affair Hospital and Oregon Health & Science University have developed a new cancer therapeutic strategy...

Published: 9/30/2022 | Inventor(s): Prakash Ambady, Ying-Jen (Jeffrey) Wu, Edward Neuwelt

Keywords(s): Therapeutics - Cancer

Category(s): Therapeutics

Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets

Summary Researchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel...

Published: 9/21/2023 | Inventor(s): Sunil Sundalam, Michael Cohen

Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases

Category(s): Chemical, Research Tools, Therapeutics

1 2