Search Results - therapeutics - cancer

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A targeted therapy to treat HER-2 positive breast cancer
Technology SummaryA novel method of treatment has been identified by OHSU researchers that has the potential to effectively treat HER-2 positive breast cancer. The approach involves using an antibody that is capable of targeting a signaling molecule responsible for tumor growth. This novel targeted therapy in combination with chemotherapy can ben...
Published: 1/18/2019   |   Inventor(s): Shiuh-Wen Luoh
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
A therapeutic approach to minimize residual disease and relapse in cancer
Technology SummaryOHSU researchers have identified a novel treatment method which, when used in combination with first-line cancer therapies, has the potential to minimize residual disease, the primary cause of relapse in all cancers. The method leverages existing drugs that inhibit a metabolic target molecule not previously understood to be invol...
Published: 1/18/2019   |   Inventor(s): George Thomas, Hui-wen Lue, Jennifer Podolak, Kevin Kolahi
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
MicroRNA inhibitors to enhance radiotherapy efficacy
Almost 50% of cancer patients undergo some form of radiotherapy; however only half of these patients have a significant response to this treatment. Higher doses of radiation can be effective, but often result in damage to nearby healthy organs. One approach to increase radiotherapy sensitivity of the targeted tissue is to enhance the efficacy of l...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Shushan Rana, Charles Thomas
Keywords(s): Diagnostics - Cancer, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Humanized leucine zipper-TRAIL fusion constructs as potent antitumor agents
Researchers at Oregon Health & Science University have engineered a humanized LZ-TRAIL fusion protein that exhibits potent anti-tumor activity in both cell based and in vivo assays.Apoptosis induced by chemotherapy and radiotherapy is dependent on the p53 tumor suppressor protein. Many cancer cells do not express p53 and thus are not responsiv...
Published: 9/27/2016   |   Inventor(s): Dmitri Rozanov
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
The use of nifedipine derivatives for enhancing Gallium uptake in chemotherapy, radiotherapy, and nuclear medicine imaging
In vivo imaging with gallium-67 is routinely used in the diagnosis of tumors, particularly in patients with Hodgkin's lymphoma; gallium scans can also be useful in non-Hodgkin's lymphoma and in certain types of carcinomas, sarcomas, and melanoma. Gallium compounds (containing stable or radioisotopes) also appear to have significant therapeutic pote...
Published: 3/23/2016   |   Inventor(s): Kathryn Morton, Jean-Baptiste Roullet
Keywords(s): Diagnostics, Therapeutics - Cancer
Category(s): Diagnostics
Treatment for Vitiligo
Piperine, Vitiligo and MelanomaTechnology 1020 Amala Soumyanath, PhDTechnology OverviewPiperine (PIP) is a natural compound that shows potential as a topical treatment for vitiligo and for melanoma. PIP has the unique ability to stimulate...
Published: 1/29/2015   |   Inventor(s): Amala Soumyanath, Zhixiu Lin, Radhakrishnan Venkatasamy, Robert Hider
Keywords(s): Therapeutics - Cancer, Therapeutics - Dermatology, Therapeutics - Immunology
Category(s): Therapeutics
Novel Pyrroloquinazolines as Anti-cancer Agents
Novel and Effective Compounds for Triple Negative Breast Cancer Researchers at Oregon Health & Science University have discovered a novel lead compound that is active against triple negative breast cancer through what is believed to be a novel (unknown at this point-target identification underway) mechanism of action. The lead compound is ...
Published: 10/16/2013   |   Inventor(s): Xiangshu Xiao, Jingjin Chen, Bingbing Li
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics, Chemical
Pharmaceutical compositions comprising napthamides
Value Proposition: Researchers at Oregon Health & Science University discovered a novel compound that regulates transcription activity of CREB via a novel mechanism of action. Lead optimization resulted in a first in class chemical series that is potent and highly selective. The efficacy of these compounds has been validated in vitro (e.g....
Published: 10/16/2013   |   Inventor(s): Xiangshu Xiao
Keywords(s): Therapeutics - Cancer
Category(s): Chemical, Therapeutics
Naphthamides as anticancer agents inhibiting CREB-mediated gene transcription
Value Proposition: Researchers at Oregon Health & Science University discovered a novel compound that regulates transcription activity of CREB via a novel mechanism of action. Lead optimization resulted in a first in class chemical series that is potent and highly selective. The efficacy of these compounds has been validated in vitro (e.g....
Published: 5/1/2013   |   Inventor(s): Xiangshu Xiao, Bingbing Li
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Chemical, Therapeutics
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