Search Results - therapeutics+-+cancer

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Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Mutation-Specific Treatment Strategies for Acute Myeloid Leukemia
Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics, Diagnostics
Anti-cancer Compounds with Improved Cardiac Safety and Drug Resistance Profiles
SummaryTyrosine kinase inhibitors are effective targeted anti-cancer therapeutics, but currently available inhibitors have limitations due to drug resistance and cardiotoxic effects. Oregon Health & Science University researchers have developed a class of kinase inhibitors with an improved cardiovascular safety profile and the potential to overcome...
Published: 9/7/2021   |   Inventor(s): Sanjay Malhotra, Mallesh Pandrala, Dhanir Tailor, Mark Mercola, Arne Antoon Bruyneel
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
A first in class small molecule as a novel YB1 inhibitor.
SummaryThe development of resistance to chemotherapy treatment in solid tumors is associated with up-regulation of the DNA/RNA binding protein Y box binding protein 1 (YB-1) and a worsened prognosis for cancer patients. Oregon Health & Science University researchers have developed a first-in-class small molecule inhibitor of YB-1 that synergizes...
Published: 9/7/2021   |   Inventor(s): Sanjay Malhotra, Dhanir Tailor
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
Novel albumin binder for improving the targeting efficacy of diagnostic or therapeutic reagents
Technology Summary Albumin binders have been developed to improve tumor uptake of therapeutic radioisotopes (radiopeptides) by prolonging radiopeptide blood circulation. However, use of these albumin binders also results in an increased uptake of radiopeptide in healthy organs, negating the benefits of the treatment. Researchers at Oregon Health...
Published: 1/28/2021   |   Inventor(s): Dexing Zeng, Lingyi Sun, Zhonghan Li
Keywords(s): Diagnostics - Cancer, Imaging, Therapeutics - Cancer
Category(s): Therapeutics, Chemical, Imaging
Radiation-enhanced delivery of antisense oligonucleotides against MGMT
SummaryMGMT is a critical enzyme driving DNA repair, and down-regulation of this molecule in tumors is linked to increased efficacy of cancer therapies that promote DNA damage and apoptosis of cancer cells. Researchers at the Veteran’s Affair Hospital and Oregon Health & Science University have developed a new cancer therapeutic strategy consisting...
Published: 1/28/2021   |   Inventor(s): Prakash Ambady, Ying-Jen (Jeffrey) Wu, Edward Neuwelt
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Small molecule activates innate immune responses controlled by the human protein STING.
SummaryStimulator of IFN genes (STING) is a signaling molecule that activates immune responses and STING-mediated phenotypes have been shown to enhance both vaccine-associated protection and immune-based antitumor therapies. Oregon Health & Science University researchers have developed a novel small molecule activating ligand of STING, which may...
Published: 6/30/2020   |   Inventor(s): Victor DeFilippis, Jinu Abraham, Sara Botto
Keywords(s): Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Vaccines, Therapeutics
A targeted therapy to treat HER-2 positive breast cancer
Technology SummaryA novel method of treatment has been identified by OHSU researchers that has the potential to effectively treat HER-2 positive breast cancer. The approach involves using an antibody that is capable of targeting a signaling molecule responsible for tumor growth. This novel targeted therapy in combination with chemotherapy can benefit...
Published: 1/18/2019   |   Inventor(s): Shiuh-Wen Luoh
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
A therapeutic approach to minimize residual disease and relapse in cancer
Technology SummaryOHSU researchers have identified a novel treatment method which, when used in combination with first-line cancer therapies, has the potential to minimize residual disease, the primary cause of relapse in all cancers. The method leverages existing drugs that inhibit a metabolic target molecule not previously understood to be involved...
Published: 1/18/2019   |   Inventor(s): George Thomas, Hui-wen Lue, Jennifer Podolak, Kevin Kolahi
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics
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