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A Fast, Broadband, Room-temperature Graphene Nanomechanical Light Detector

1. Technology Overview The invention focuses on a fast, broadband, room-temperature graphene nanomechanical light detector. This device detects light by measuring shifts in the mechanical resonance of suspended graphene, which changes its pitch when it absorbs light and warms up. The technology is currently in the development stage, with promising...

Published: 1/8/2026 | Inventor(s): Benjamin Aleman

Keywords(s): Science

Category(s): Communications, Engineering, Imaging, Nanoscience & Microtechnologies, Physical Science

Non-Linear Single-Molecule FRET

1. Technology Overview The invention introduces a novel method for measuring the relative orientation of donor-acceptor (D-A) pairs in fluorescence resonance energy transfer (FRET) microscopy. This method leverages non-linear spectroscopy and phase-tagged photon counting to achieve precise measurements of the relative orientation and distance between...

Published: 12/31/2025 | Inventor(s): Andy Marcus, Claire Albrecht

Keywords(s):

Category(s): Imaging, Diagnostics

Artificial Intelligence-Assisted Projection-Resolved Optical Coherence Tomographic Angiography (aiPR-OCTA)

Summary The current artificial intelligence algorithm removes projection artifacts in optical coherence tomographic angiography images and improves the signal-to-noise ratio. Technology Overview A major limitation of optical coherence tomography angiography (OCTA) are image artifacts, particularly projection artifacts, which make the detection of...

Published: 1/7/2025 | Inventor(s): Yali Jia, Jie Wang

Keywords(s): Imaging, Imaging - Other

Category(s): Imaging

An OCT method to improve scleral lens fitting

Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...

Published: 9/4/2025 | Inventor(s): David Huang, Yan Li, Clara Llorens Quintana

Keywords(s): Imaging, Imaging - Other, Software, Software - Diagnostic/Detection

Category(s): Imaging, Software

Postprocessing algorithms to minimize fixed pattern artifact and reduce trigger jitter in swept source OCT

Summary OHSU developed post-processing algorithms which could minimize fixed pattern artifact and reduce trigger jitter in swept source optical coherence tomography (SS-OCT). Technology Overview Swept-source OCT has advantages of less fringe washout and faster imaging speeds compared to conventional spectraldomain detection. Therefore, it is attractive...

Published: 9/27/2023 | Inventor(s): Gangjun Liu, David Huang

Keywords(s):

Category(s): Device, Imaging, Engineering, Software

Retinomorphic Sensors

This sensor, intended for use in computer vision applications, only produces a signal in response to changes in light conditions. Background Inspired by the way retinal cells respond to light, retinomorphic sensors are hoped to enable faster identification of moving objects than software-based approaches. Unlike conventional optical sensors, such...

Published: 8/4/2025 | Inventor(s): John Labram

Keywords(s):

Category(s): Device, Engineering, Imaging, Materials Science, Nanoscience & Microtechnologies, Physical Science, Transportation

Nanoparticle ultrasound contrast agents with high acoustic activity

Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...

Published: 11/22/2023 | Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics

Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics

Anoxic/hypoxic brain imaging map

Summary Brain damage in newborns arises as a consequence of oxygen shortage in the brain. This injury is often difficult to diagnose in young children due to intrinsic differences between the developing and adult brain. Scientists at OHSU have developed a highly-accurate diagnostic analysis to localize brain injuries in developing as well as adult brains....

Published: 3/16/2023 | Inventor(s): Jeffrey Pollock, Ningcheng (Peter) Li

Keywords(s): Diagnostics, Diagnostics - Neurology, Imaging, Imaging - MRI

Category(s): Diagnostics, Imaging

Metabolic activity diffusion imaging (MADI): dye-free, high-resolution MRI metabolic imaging

Summary The current technology is a contrast agent-free method of metabolic imaging based on detection of Na/K ATPase activity with MRI, that provides significantly higher resolution than current approaches such as PET. Technology Overview Measuring metabolic activity in vivo can facilitate diagnoses of disease states and therapeutic responses....

Published: 1/15/2024 | Inventor(s): Gregory Wilson, Jeffrey Maki, Charles Springer, Jr., Xin Li, William (Bill) Rooney, Brendan Moloney, Wei Huang, Tom Barbara, Eric Baker

Keywords(s): Diagnostics, Imaging, Imaging - MRI, Software, Software - Other

Category(s): Imaging, Software

Label-free fluorescent sensing of protease activity

Summary The current technology offers advantages over existing protease probes, with lower background noise, simplified label-free synthesis, compatibility with any protease of interest and utility for translational research and clinical diagnostics. Technology Overview Dysregulated proteolytic activity is linked to many human diseases, including...

Published: 7/19/2024 | Inventor(s): Adem Yildirim, Bruce Branchaud, Justin Plaut, Srivathsan Ranganathan, Sean Speese, Corey Dambacher, Sarah Barnhill, Emma Olson

Keywords(s): Diagnostics, Imaging, Imaging - Other, Research Tools

Category(s): Imaging, Research Tools, Diagnostics

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