Search Results - diagnostics

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Novel Second Generation Fluorescent Dyes For In Vivo Nerve-specific Imaging
Technology SummaryResearchers at Oregon Health & Science University have developed a second generation of novel, nerve-specific fluorescent dyes for diagnostic use in image-guided surgery. The fluorophores can be administered directly to the surgical site or intravenously for the precise visual identification of nerves. Technology OverviewDuri...
Published: 1/4/2019   |   Inventor(s): Summer Dowell (Gibbs), Lei Wang, Connor Barth
Keywords(s): Diagnostics, Imaging
Category(s): Diagnostics, Imaging
Adipose-specific fluorescent dyes for in vivo imaging
Technology SummaryResearchers at Oregon Health & Science University have developed novel adipose-specific fluorescent dyes for use in image-guided surgery of anatomical structures, such as nerves, that are surrounded by adipose tissue. The generated fluorophores exhibit reduced nerve accumulation, and demonstrate higher adipose-to-nerve and adi...
Published: 1/4/2019   |   Inventor(s): Jesse Korber, Connor Barth, Summer Dowell (Gibbs)
Keywords(s): Diagnostics, Imaging
Category(s): Diagnostics, Imaging
Novel Fluorescent Dyes for In Vivo Nerve-Specific Imaging
Technology SummaryResearchers at Oregon Health & Science University have developed novel, small molecule near infrared (NIR) nerve-specific fluorophores for diagnostic use in fluorescence-guided surgery. The fluorophores can be administered directly to the surgical site or intravenously for the precise visualization of nerves during surgical pr...
Published: 11/8/2018   |   Inventor(s): Summer Dowell (Gibbs), Lei Wang, Connor Barth
Keywords(s): Diagnostics, Imaging
Category(s): Diagnostics, Imaging
System to measure sleep apnea using portable non-contact sensors and a machine learning algorithm
SummaryMethod and system for automatic diagnosis of sleep apnea in the home environment. The system uses pressure sensitive sensors placed underneath a mattress and an algorithm to classify the severity of sleep apnea.Technology OverviewThis in home system to diagnose sleep apnea saves the patient from having to spend a night in a sleep clinic atta...
Published: 8/31/2018   |   Inventor(s): Peter Jacobs, Clara Mosquera-Lopez, Joseph Leitschuh, John Condon
Keywords(s): Device, Diagnostics
Category(s): Device, Diagnostics
Contrast-Enhanced Magnetic Resonance Imaging for Detection and Quantification of Fibrosis in Human Myocardium
Technology OverviewMyocardial fibrosis is a morphologic change common to multiple cardiac disease conditions. In addition to replacement (scar) fibrosis, there is increasing recognition of interstitial (reactive) fibrosis acting as an important player in structural remodeling of the diseased heart, as well as the genesis of fatal arrhythmia leading...
Published: 3/16/2018   |   Inventor(s): Michael Jerosch-Herold, Sumeet Chugh
Keywords(s): Diagnostics, Diagnostics - Cardiology, Imaging, Imaging - MRI, Software
Category(s): Diagnostics
Algorithm For Automated Detection of Melanoma
Technology Overview Comprehensive diagnosis of melanoma typically requires both reliable histopathology and the trained eye of a clinician for assessment. With optical (as opposed to physical) sectioning of tissue and OHSU created software to process confocal images, it is possible to distinguish the diagnostic traits of malignancy, such as the...
Published: 11/9/2017   |   Inventor(s): Daniel Gareau, Ricky Hennessy, Steven Jacques
Keywords(s): Device, Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software
Category(s): Diagnostics
MicroRNA Biomarkers for Alzheimers Disease
A method to assess the presence of Alzheimer’s disease in a human by obtaining a sample of cerebrospinal fluid and extracting total RNA to determine the expression levels of extracellular micro RNA biomarkers.A US provisional patent application filed 8/19/2016. A PCT patent application filed 8/18/2017.
Published: 8/1/2017   |   Inventor(s): Julie Saugstad, Joseph Quinn, Jodi Lapidus, Christina (chris) Harrington, Theresa Lusardi, Jay Phillips, Jack Wiedrick, Babett (betty) Lind
Keywords(s): Diagnostics, Diagnostics - Neurology
Category(s): Diagnostics
Novel activating NTRK2 and NTRK3 mutations as biomarkers for NTRK inhibitor sensitivity in cancer
Neurotrophic receptor tyrosine kinases (NTRK) are a family of genes involved in neuronal development. Mutations in these proteins result in dysregulation of neurons and may increase the risk of disease. NTRK gene fusions have previously been implicated as oncogenic drivers in various solid tumors. Researchers at OHSU have now identified four novel ...
Published: 7/3/2017   |   Inventor(s): Cristina Tognon, Monika Davare, Kristin Qian, Brian Druker
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Diagnosis of Human Malignances Associated with Activating Mutations of Platelet Derived Growth Factor Receptor Alpha (PDGFRA)
Tyrosine kinases are expressed in many human cancers and are attractive targets for the development of anticancer therapies. Clinical response to these therapies is often correlated with the mutational status of the target. The identification of a particular mutation in a patient’s tumor therefore can be used to identify which patients are m...
Published: 6/15/2017   |   Inventor(s): Michael Heinrich, Christopher Corless, Jonathon Fletcher, George Demitri
Keywords(s): Diagnostics
Category(s): Diagnostics
microRNA mimics and inhibitors to modulate genotoxic stress for cancer and aging related diseases.
MicroRNAs (miRs) can regulate gene expression and are often critical players in controlling cellular DNA repair mechanisms. miRs can therefore provide an alternative therapeutic strategy for treatment of cancer and other diseases associated with altered miR expression and/or DNA damage repair.Researchers at OHSU have identified a cohort of miRs tha...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Maria (cristina) Espinosa-Diez
Keywords(s): Diagnostics, Therapeutics
Category(s): Diagnostics, Therapeutics
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