Search Results - diagnostics

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Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Mutation-Specific Treatment Strategies for Acute Myeloid Leukemia
Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics, Diagnostics
Algorithm for assessing retinal fluid volume using OCT/OCTA
SummaryMeasurement of retinal fluid volume could improve diagnosis and tracking of diabetic macular edema (DME); however, current methods rely on two-dimensional measurements, which have limited accuracy. The current technology uses volumetric OCT/OCT angiography scans to provide a three-dimensional and more accurate retinal fluid volume, potentially...
Published: 10/29/2021   |   Inventor(s): Yali Jia, Yukun Guo
Keywords(s): Diagnostics, Diagnostics - Other, Imaging, Imaging - Other, Software, Software - Other
Category(s): Diagnostics, Imaging, Software
Improved detection of heart-rate variability for wearable devices
Summary Heart-rate variability (HRV) is a suggested marker of the autonomic nervous system, but artifacts produced by movement with wrist worn devices decreases the validity and utility of this data. Oregon Health & Science University researchers have developed an improved method of removing motion artifacts, understanding the amount of data that...
Published: 10/4/2021   |   Inventor(s): David Sheridan, Steven Baker, Ryan Dehart
Keywords(s): Diagnostics, Research Tools, Software
Category(s): Diagnostics, Research Tools, Software
Quantification of Vascular Abnormality with OCT Angiography
SummaryCurrent OCT techniques are limited in their ability to accurately detect vasculature changes, and patients with retinal vascular diseases often require more invasive intravenous contrast dye-based angiography procedures. The current technology is an OCT-based non-injection, dye-free method that allows for 3D visualization of superimposed structural...
Published: 8/3/2021   |   Inventor(s): David Huang, Yali Jia
Keywords(s): Diagnostics, Imaging, Imaging - Other, Software
Category(s): Diagnostics, Imaging, Software
Subtyping Autism Using a Novel Machine Learning Method
Summary Autism spectrum disorder (ASD) is a heterogenous disease, making it difficult to develop diagnostic measures and effective treatments. Oregon Health and Science University researchers have developed a novel AI method for identifying ASD subgroups, which could help refine ASD diagnostic criteria and further the study of precision medicine for...
Published: 7/6/2021   |   Inventor(s): Eric Feczko, Damien Fair, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Neurology, Diagnostics - Other, Research Tools, Software - Diagnostic/Detection
Category(s): Diagnostics, Research Tools, Software
Phonological Feature-based Automatic Pronunciation Analysis and Feedback System
Summary Speech sounds disorders are common in foreign language learners and school-age children and current effective treatments rely largely on prolonged in-person speech therapy that is unavailable to many due to location or resources. Oregon Health & Science University (OHSU) researchers have developed a computer-assisted pronunciation training...
Published: 4/27/2021   |   Inventor(s): Alexander Kain, Amie Roten
Keywords(s): Diagnostics, Diagnostics - Other, Education & Training - Speech & Language, Software - Diagnostic/Detection
Category(s): Diagnostics, Education & Training, Speech & Language
Self-tracking real-time high-resolution wide-field OCT angiography (OCTA)
SummaryOptical coherence tomographic angiography (OCTA) provides superior resolution and volumetric data compared to fluorescein angiography, but this 3D technology requires motion artifact compensation caused by movements during the scan. Oregon Health & Science University researchers have developed a method to suppress motion artifacts caused...
Published: 4/13/2021   |   Inventor(s): Yali Jia, Xiang Wei
Keywords(s): Diagnostics, Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Software, Imaging
Nanoparticle ultrasound contrast agents with high acoustic activity
SummaryContrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 2/24/2021   |   Inventor(s): Adem Yildirim, Jose Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
Novel Fluorescent Dyes for In Vivo Nerve-Specific Imaging
Technology SummaryResearchers at Oregon Health & Science University have developed novel, small molecule near infrared (NIR) nerve-specific fluorophores for diagnostic use in fluorescence-guided surgery. The fluorophores can be administered directly to the surgical site or intravenously for the precise visualization of nerves during surgical procedures,...
Published: 9/16/2020   |   Inventor(s): Summer Dowell (Gibbs), Lei Wang, Connor Barth
Keywords(s): Diagnostics, Imaging
Category(s): Diagnostics, Imaging
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