Latest technologies from Oregon Portal

cDNA Clone Encoding the RGK5 (Kv1.3) Voltage-Gated Potassium Channel

dincherk@ohsu.edu — Tue, 22 Jun 2010 11:29:03 GMT

Technology OverviewLow stringency hybridization screening of a rat genomic DNA library with a previously described cDNA clone encoding a rat voltage-gated potassium channel has resulted in the characterization of a member of the potassium channel family, RGK5. An uninterrupted nucleotide sequence encodes a protein 525 amino acids in length, revealing that the entire coding region resides on a single exon. RGK5 transcripts are present in both mouse thymus and rat brain, as determined by Northern blot analysis. RNA transcribed in vitro from RGK5 genomic DNA directs the...

Novel molecules of rhamnolipids produced by the polycyclic aromatic hydrocarbons-degrading bacterium Pseudomonas aeruginosa strain NY3

mary.foley@oregonstate.edu — Fri, 11 Jun 2010 20:52:05 GMT

This invention from the laboratory of Dr. Xihou Yin describes a new strain of bacteria that is non-toxic, comparatively inexpensive to produce, and can effectively help degrade “polycyclic aromatic hydrocarbons,” or PAHs – environmental pollutants that are one of the most harmful aspects of oil spills. The bacterial strain is Pseudomonas aeruginosa. This particular strain has been found to be unique in its capability to produce rhamnolipids in very high quantities (600 hundred fold) that can break down oil, and then degrade some of its most serious toxic compounds, the PAH...

Flagmor transgenic mouse

dincherk@ohsu.edu — Fri, 30 Apr 2010 15:34:55 GMT

Value PropositionFLAGMOR transgenic mice provides an advantage to studying signal transduction of mu-opioid receptors (MOR) through the activation of potassium-ion channels, desensitization, and receptor trafficking. A better understanding of the underlying mechanisms of MOR activation will lead to improved opioid treatment and research. Technology OverviewMu-opioid receptors are a class of G-protein coupled receptors found primarily in the CNS and the GI system. The activation of MOR by opioids cause decreased perception of pain, decreased reaction to pain, and increased pai...

Attenuated Francisella Mutants for Use in Prevention and Treatment of Tularemia

dincherk@ohsu.edu — Fri, 30 Apr 2010 15:34:55 GMT

Technology OverviewFrancisella tularensis is a Gram-negative, facultative intracellular pathogen that causes tularemia, a debilitating and potentially fatal disease that affects humans and a wide range of animals. Infections can be acquired through bites from an arthropod vector, skin lesions, ingestion of contaminated food or water, and by inhalation of a few as 10 bacteria. The low dose required to cause tularemia by aerosol route resulted in the development of F. tularensis for use as a biological weapon by several national weapons programs. The CDC has classifi...

Electronic detection of ligand-receptor interactions

dincherk@ohsu.edu — Fri, 30 Apr 2010 15:34:53 GMT

Technology OverviewThis biosensor technology enables the direct electrical detection of molecules in solution. Detection is accomplished by the simultaneous monitoring of several dielectric parameters – including capacitance, dissipation factor, conductance, impedance, and phase – over a selected alternating current frequency range. The resulting dielectric parameter/frequency patterns combine to form a unique “fingerprint” for the tested molecule. These patterns are sufficiently unique to identify unknown molecules in experimental samples from a database of known p...

Novel methods to promote remyelination using selective inhibitors

dincherk@ohsu.edu — Fri, 30 Apr 2010 14:48:20 GMT

Value PropositionTreatment of a demyelinating disease or reduction in the risk of developing a demyelinating disease is accomplished through the use of selective inhibitors and methods covered by this invention. Technology OverviewMyelin is the protective coating surrounding nerve fibers in the brain and spinal cord. Demyelination is the destructive breakdown of myelin and death of oligodendrocytes (OL), special glial cells that are responsible for the production of myelin, following inflammatory, ischemic and traumatic insults in the brain and spinal cord. Such causes interfere wit...

Gene silencing therapy for rheumatoid arthritis and other chronic inflammatory/autoimmune diseases

dincherk@ohsu.edu — Fri, 30 Apr 2010 14:48:20 GMT

Value PropositionLong term suppression and remission of rheumatoid arthritis and other chronic inflammatory/autoimmune diseases with RNA interference therapy. Technology OverviewRheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by synovitis and joint destruction with unknown etiology. Current understanding of the pathogenesis of RA is the interplay of innate and adaptive immune responses. The discovery of the importance of several inflammatory cytokines led to the development of highly efficacious therapies for RA. However, disease ...

Use of Toll-like receptor ligands in preventing and treating excitotoxic, ischemic and/or hypoxic damage

dincherk@ohsu.edu — Fri, 30 Apr 2010 14:48:20 GMT

Value Proposition: This novel discovery covers the use of Toll-like receptor (TLR) ligands for neuroprotection and treatment both before and after excitotoxic, ischemic and/or hypoxic events. Technology Overview: Adverse effects of ischemic and other hypoxic conditions resulting from stroke and other vascular diseases are a huge medical concern because they lead to neurological injury and death. Researchers have investigated stroke pathogenesis and treatment for decades. They have revealed robust neuroprotective treatments in the laboratory, however, all have failed to t...

Peptide-based treatment for neurodegenerative diseases and other neuropathies

dincherk@ohsu.edu — Fri, 30 Apr 2010 14:48:19 GMT

Value PropositionNovel peptide agents that can access the central nervous system and have therapeutic potential in neurodegenerative diseases. Technology Overview Neurodegeneration is often caused by misfolding of proteins such that they can no longer perform their cellular functions and instead trigger equivalent modifications in normal proteins, thus creating a cascade of damage that eventually results in significant neuronal death. Moreover, few therapies are available for the treatment of most neurodegenerative diseases even once the disease has been identified. The treat...

De-identified DNA samples from subjects with hereditary vascular diseases of the retina

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:37 GMT

Technology OverviewThe DNA samples were collected from patients with hereditary vascular diseases of the retina seen in the Ophthalmic Genetics Service at the Casey Eye Institute at OHSU. They were collected via a longstanding, grant funded study which allows OHSU to bank patient DNA samples. IRB approval is required prior to OHSU sending out the de-identified samples requested. The price shown is a per sample price. After clicking on the "Add to Order" button below, on the following webpage please enter the quantity of s...

BESTest incline ramp tool

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:28 GMT

This is the incline ramp tool used in the BESTest-10 degree incline ramp (at least 2 x 2 ft) to stand on. To acquire the BESTest training DVD in addition to this tool, please see: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=217191

BESTest medium density foam block tool

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:28 GMT

This is the foam block tool used in the BESTest- approximately 60 cm x 60 cm (2 X 2 ft) block of 4-inch, medium-density, Tempur® foam. To acquire the BESTest training DVD in addition to this tool, please see: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=217191

CORI- Pathology interface with GI Pathology Partners

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:27 GMT

Technology OverviewThis is to obtain a license to the CORI-Pathology interface with GI Pathology Partners' GI Connect. An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621

CORI- Pathology interface with Caris Diagnostics

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:27 GMT

Technology OverviewThis is to obtain a license to the CORI-Pathology interface with Caris Diagnostics' laboratory integrated system (LIS). An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621

CORI- Pathology import using HL7

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:26 GMT

Technology OverviewThis is to obtain a license to the CORI-Pathology import software using HL7. An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621

CORI- Image import using HL7

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:26 GMT

Technology OverviewThis is to obtain a license to the CORI-Image import software using HL7. An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621

CORI- ADT interface using HL7

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:26 GMT

Technology OverviewThis is to obtain a license to the CORI-ADT (Admission Discharge Transfer) software interface using HL7. An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621

CORI Endoscopy Procedure Software (yearly service & updates)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:26 GMT

Technology OverviewThis is a subscription for one year of updates to the CORI Software and up to 20-hours of expert technical support. Once 20 hours of support time has been utilized, additional hours can be purchased at a charge of $50/hour. An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621 All terms of the base software license agreement from the CORI Endoscopy Procedure Software license apply to all updates.

CORI Endoscopy Procedure Software- 5-extra logins

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:25 GMT

Technology OverviewNote: This is to obtain a license to 5 additional logins. An initial license agreement for CORI Endoscopy Procedure Software must first be obtained. Visit: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425621 All terms of the base software license agreement from the CORI Endoscopy Procedure Software license apply.

Mexican Spanish female diphone voice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:19 GMT

Technology Overview Recordings of a female Mexican-Spanish human voice processed and reformatted to be usable as an Acoustic Inventory Corpus (AIC) by the OGIresLPC sub-system (OHSU #0631) in the Festival open-source text-to-speech system. The AIC consists of time-stamped digital recordings of raw speech or processed speech together with index files that map phoneme sequences via the time stamps to corresponding time stamps in the digital recordings. The AIC was designed to have optimal coverage of phoneme sequences in which substantial coarticulation can be expected.

Mexican Spanish male diphone voice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:19 GMT

Technology Overview Recordings of a male Mexican-Spanish human voice processed and reformatted to be usable as an Acoustic Inventory Corpus (AIC) by the OGIresLPC sub-system (OHSU #0631) in the Festival open-source text-to-speech system. The AIC consists of time-stamped digital recordings of raw speech or processed speech together with index files that map phoneme sequences via the time stamps to corresponding time stamps in the digital recordings. The AIC was designed to have optimal coverage of phoneme sequences in which substantial coarticulation can be expected.

American English female diphone voice (TL)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:19 GMT

Technology Overview Recordings of a female American-English human voice processed and reformatted to be usable as an Acoustic Inventory Corpus (AIC) by the OGIresLPC sub-system (OHSU #0631) in the Festival open-source text-to-speech system. The AIC consists of time-stamped digital recordings of raw speech or processed speech together with index files that map phoneme sequences via the time stamps to corresponding time stamps in the digital recordings. The AIC was designed to have optimal coverage of phoneme sequences in which substantial coarticulation can be expected.

American English female diphone voice (AS)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:18 GMT

American English male speaker diphone voice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:18 GMT

Technology Overview Recordings of a male American-English human voice processed and reformatted to be usable as an Acoustic Inventory Corpus (AIC) by the OGIresLPC sub-system (OHSU #0631) in the Festival open-source text-to-speech system. The AIC consists of time-stamped digital recordings of raw speech or processed speech together with index files that map phoneme sequences via the time stamps to corresponding time stamps in the digital recordings. The AIC was designed to have optimal coverage of phoneme sequences in which substantial coarticulation can be expected.

German male speaker diphone voice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:18 GMT

Technology Overview Recordings of a male German human voice processed and reformatted to be usable as an Acoustic Inventory Corpus (AIC) by the OGIresLPC sub-system (OHSU #0631) in the Festival open-source text-to-speech system. The AIC consists of time-stamped digital recordings of raw speech or processed speech together with index files that map phoneme sequences via the time stamps to corresponding time stamps in the digital recordings. The AIC was designed to have optimal coverage of phoneme sequences in which substantial coarticulation can be expected.

German female speaker diphone voice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:17 GMT

Technology Overview Recordings of a female German human voice processed and reformatted to be usable as an Acoustic Inventory Corpus (AIC) by the OGIresLPC sub-system (OHSU #0631) in the Festival open-source text-to-speech system. The AIC consists of time-stamped digital recordings of raw speech or processed speech together with index files that map phoneme sequences via the time stamps to corresponding time stamps in the digital recordings. The AIC was designed to have optimal coverage of phoneme sequences in which substantial coarticulation can be expected.

BB19 Cell Line

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:08 GMT

Technology OverviewThe inventors developed an immortalized human brain capillary endothelial cell line named BB19. BB19 cells are derived from human brain endothelium and are immortalized with E6E7 genes of human papilloma virus. This cell line has been used to study cytoadherence of Plasmodium falciparum-infected erythrocytes in vitro. The cells partly maintain endothelial properties as shown by tubule formation with MatrigelTM as substrate. They express Factor VIII-related antigen and von Willebrand’s factor. The cells exhibit cobblestone like mo...

CtBP1, CtBP2, PARP-1, PARP-2 and Chk-1 Knockdown Stable Cell Lines

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:08 GMT

Technology OverviewA number of cell lines have been produced to knockdown single or multiple isoforms of specific genes by siRNA so that their promoter specific effects could be studies. These various cell lines were used in order to study regulation of the p21 promoter, the E-cadherin promoter, and cell cycle checkpoint gene regulation in response to DNA damage insults such as chemotherapy, ionizing radiation and free radical damage. Parent Cell Lines: HeLa (cervical adenocarcinoma), H1299 (Lung adenocarcinoma, p53 null), MCF-7 (Breast carcinoma), U2OS (osteosarco...

C-Terminal Binding Protein (CtBP) single isoform lentiviral stable cell lines

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:07 GMT

Technology OverviewThese cell lines re-introduce CtBP wild type and functional mutant isoforms (both CtBP1 and 2) back into a CtBP1+2 null mouse embryonic fibroblast (MEF) line. These cells contain lentiviral-introduced protein encoding sequences that allow for stable expression of physiologic levels of CtBP isoforms under the tetracycline operon regulated promoter. This results in a cell in which either the wild type or mutant CtBP (1 or 2) is expressed in isolation, allowing study of gene specific regulatory events that are thought to be reliant upon CtBP. These lines a...

DNA Repair Enzymes: T4-pdg and cv-pdg pyrimidine dimer-specific DNA glycosylase/abasic site lyases

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:32:00 GMT

Technology Overview DNA repair enzymes T4-pdg and cv-pdg are useful reagents which can be sold individually or in kits. These enzymes are pyrimidine dimer-specific DNA glycosylase/abasic site lyases that are routinely used to quantitate cyclobutane pyrimidine dimers in UV-irradiated DNAs. The genes encoding each lysase are PCR amplified in order to engineer unique DNA restriction sites and subcloned into an E. coli expression vector with an inducible promoter and a 6 histidine tag for single step purification. The purity of the preparation is assessed and the final concentration...

Jolene Instruction Manual

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:58 GMT

Technology OverviewJolene is a system for measuring the sound levels of personal stereo systems. She is part of the Dangerous Decibels education and research projects. Jolene was constructed using a used fashion mannequin and a sound level meter wired to a silicon ear. Jolene makes appearances at schools and universities, scientific meetings, health fairs, and many other public events. She always attracts a crowd and is helpful for promoting noise-induced hearing loss and tinnitus prevention. Jolene has also been used as a research tool to study the beliefs and listening pra...

Jolene personal sound level measurement device

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:58 GMT

Technology Overview "Jolene" is a mannequin built and attired to appeal to young people. It is a sound level measurement system for measuring output of personal stereo devices commonly used by young people. Jolene can easily be transported to schools for use in hearing health education.

Bacterial artificial chromosome (BAC) clone containing the genome of human cytomegalovirus (HCMV) TR strain

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:56 GMT

Technology Overview The TR BAC was prepared from the TR clinical HCMV isolate. This virus is resistant to ganciclovir and cidofovir and lacks UL97 codons 591-594. The BAC clone was generated by substituting BAC DNA for the US2-US5 region of the TR genome. The TR strain infects almost any diploid endothelial or epithelial cell as well as macrophages. This strain is useful for studies on HCMV including genetic studies. PublicationProc Natl Acad Sci U S A. 2003 Dec 9;100(25):14976-81 "Coding potential of laboratory and clinical strains of human cytomegalovirus" ...

Adjustable implant for medialization laryngoplasty to correct vocal paralysis and vocal cord bowing

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:53 GMT

Technology Overview Medialization laryngoplasty involves placing a prosthetic device into the larynx to push the vocal fold medially to improve voice and/or swallowing function in patients with vocal paralysis or paresis. This device, once placed is not able to be modified without a surgical procedure requiring explanation and reimplantation. The size of the implant is patient specific and requires trial and error techniques to determine the proper size. There are a substantial number of patients where the voice/swallowing result is not ideal but the risk and complex...

Clear-Speech Corpus, Speaker JPH

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:51 GMT

Technology OverviewCorpus collected for analyzing differences between two speaking styles, i.e. "clear" and "conversational" speech. Provides 140 sentences and parrallel recordings of clear and conversational speech as well as associated phonetic labels and manually verfied pitch marks, i.e. glottal closure instants. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions. Corporate members can use these corpora for research but also for creating commercial products such as generating acoustic models for speech re...

Ototoxicity Project Data Collection System

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:32 GMT

Technology Overview Investigators at the Child Development and Rehabilitation Center have developed a computer software package that allows for consistent, organized collection of audiological data on children receiving cisplatin chemotherapy for ototoxicity assessment. This is not a case management system; rather, the software provides a consistent method that may be used nationwide to enable statistical data analysis with significant results.

Controlling Formant Frequencies in Concatenative Speech Synthesis Systems

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:30 GMT

Technology Overview In the process of generating a speech signal from a textual representation, a Text-to-Speech system must at some point generate an acoustic waveform from a symbolic linguistic representation. This step can be solved with the help of a speech model of variable complexity. The first synthesizers used an approach called formant synthesis which utilizes relatively simple models focusing on formant trajectories; parameters can be generated either by rule or from a database. All aspects of speech are controllable, including the degree of articulation and sp...

Noninvasive Nasal Flow Measurement Device and Algorithm

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:30 GMT

Technology Overview Researchers at the Center for Spoken Language Understanding have devised a non-invasive device to monitor the velopharyngeal port (VP) during speech by measuring nasal airflow. Airflow signals from the subject's nostril are transmitted to a computer where the patterns are analyzed with proprietary algorithms. Analysis of the signals provides information about the velopharyngeal port during speech, nasal airflow, as well as inhalation and exhalation. During normal speech production, the opening and closing of the VP is important for proper speech patterns.&nbs...

Cell Free Screening Assay

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:29 GMT

Technology Overview The Hoatlin Cell-Free Screening Assay is biochemical assay platform that was initially developed to study proteins in the Fanconi Anemia-Breast Cancer (FA-BRCA) pathway. Derangements in the FA-BRCA pathway are common in a number of cancers, including breast cancer, head and neck cancers, and ovarian cancer. This versatile assay can be used to screen for drugs that can either stimulate or inhibit the pathway. The assay is adaptable to high throughput screening. The cell-free assay is based on the preparation of replicating extract from Xenopus eggs. The egg e...

Rapid Test for Dental Caries Risk

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:29 GMT

Technology OverviewResearchers at the OHSU School of Dentistry have developed methods and kits to rapidly detect the presence of dental cavity causing bacteria in dental plaque and/or saliva and to assess the risk in a patient of developing dental cavities based upon the presence of one or more species of cavity causing bacteria. This method is easy to use, fast, and convenient since it can be administered in the dental office with quantitative results obtained after 20 minutes. The risk for a patient to develop dental caries can then be assessed based on the presence or absence of part...

On the Same Page

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:28 GMT

Technology Overview Researchers at OHSU's Child Development and Rehabilitation Center have developed additional materials in the Design to Learn program. On the Same Page is a form to enter the results of communication and concept development skills derived from various tools. This form accompanies the Design to Learn package of materials. It is used for integrating assessment information from home and school and for developing and monitoring an integrated learning plan for an individual student. For more information, visit: http://www.designtolearn.com/pages/os...

Design to Learn Model and Instructional Materials

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:28 GMT

Technology Overview Researchers at OHSU's Child Development and Rehabilitation Center have developed a program called Design to Learn. For more information ,visit: www.designtolearn.com. The Design to Learn Model and Instructional Materials is a booklet describing instructional models and related instructional/assessment materials appropriate for children with severe and/or multiple disabilities.

Newborn Screening Long-Term Follow-up Data Collection System

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:24 GMT

Technology Overview The Newborn Screening Long-term Follow-Up Data Collection System is a tool to collect and organize data of newborns for inherited, rare, metabolic disorders. The disorders fall into three different biochemical categories: fatty acid oxidation, organic acid or amino acid disorders. The collection system organizes data according to biochemical, physical, and mental parameters that are important to the long-term follow-up of newborns. While the collection system allows for the evaluation of efficacy of screening and treatment, it is not a case management ...

Effective antimicrobial for use in serological diagnostic tests

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:24 GMT

Technology Overview Researchers at OHSU's Vaccine and Gene Therapy Institute have uncovered a means of using an antimicrobial agent as a method for inactivation of blood pathogens during serological diagnosis. Since this agent has broad-spectrum antimicrobial functions including antiviral, antibacterial, antifungal, and possibly anti-parasitic, it may be useful as an inactivating agent for a wide variety of microbes that might be encountered during clinical studies with human patients. The scope of this technology would encompass drawing a blood sample into a special vacutain...

Aromatic ketones and uses thereof.

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:22 GMT

Technology OverviewResearchers at OHSU and Portland's VA Medical Center have discovered a series of chemical compounds, namely naphthoquinones, anthraquinones, and anthrones, that contain a unique and defining structural element making them selectively potent antiparasitic agents. These new compounds exhibit an improvement in antimalarial potency of over 50 fold (as compared with currently used therapeutics) against most multidrug resistant strains of the malarial parasite. The new compounds act by a different mechanism than commercially available compounds against stra...

CyP-D Knock-Out Mice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:18 GMT

Technology Overview Cyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies. These animals and their cells can be used to test the in vivo role of the mitochondrial permeability transition in various pathological responses of relevance to human disease; specifically, models of ischemia/reperfusion injury in heart and brai...

Nanoparticle Platforms for Sorting, Capture, and Placement of Cells

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:17 GMT

Technology Overview Quantum dot (QD) NanoArrays have great potential to address many stringent criteria that are needed--such as highly sensitive, rapid, cell-accessible and cell-specific techniques--to detect and target chemical events occurring in nanometer-sized cellular structures. Dr. Tania Vu has developed a specific method for creating printed arrays of individual nanoparticle probes capable of capturing, sorting and measuring interactions of single bioactive molecules, providing a multi-use, customizable platform for detection, visualization and further characterizatio...

Educational Videotape About Retinopathy of Prematurity and Cryotherapy

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:16 GMT

Technology Information This video is used as an educational aid concerning the retinopathy of prematurity intended for an audience of students, nurses and lay people. Approximately 18 minutes long. Available in video and CD-Rom.

Patient Privacy Screen

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:16 GMT

Technology Overview A Patient Privacy Screen has been developed to be used around a patent stretcher or bed during transport to protect their privacy and confidentiality during transport.

Fundamental Frequency Extraction Method Version 1.0

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:15 GMT

Technology Overview Inventors working at the Department of Science and Engineering developed a method to analyze a speech signal and estimate the pitch or fundamental frequency throughout the duration of the speech signal. Fundamental frequency (F0) is a measure of the rate at which the vocal folds vibrate during voiced speech (such as vowels). The range of F0 values of a particular speaker depends on the physical, emotional, and social characteristics of that person. If the speaker characteristics (and thus the range of expected F0 values) are not known in advance, ma...

Methods for Detecting and Treating Autoimmune Disorders

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:07 GMT

Technology Overview This invention relates to methods for inhibiting an autoimmune disease by adminstering to a subject a therapeutically effective amount of a composition that increases FOXP3 expression, thereby inhibiting the autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease. Patent Profile US Patent Application 11/658,834 published 8/20/2008 as US-2009-0010885

Design to Learn - First Things First: Early Communication for Pre-symbolic Child with Severe Disabilities

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:07 GMT

Technology Overview Instructional guide for speech-language pathologists, teachers and parents to encourage early communication in children who have no or minimal intentional communication. First Things First describes instructional strategies for children who are not yet ready to use symbols to communicate. For more information and to order products, please visit: http://www.designtolearn.com/pages/FTF.html

Mutated ABL Kinase Domains

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:31:06 GMT

Technology OverviewSTI-571 is a tyrosine kinase inhibitor, specifically inhibiting the proliferation of the BCR-ABL-expressing hematopoietic cells responsible for chronic myelogenous leukemia (CML). STI-571, under the name Gleevec (Novartis), is now a commonly prescribed drug for CML and also AML, acute myelogenous leukemia and gastrointestinal stromal tumors (GISTs). This drug has been show to be extremely successful in limiting the growth of cancerous cells and relieving the fear of blast crisis in CML patients. However, patients within the CML population have been identified ...

DialogueView Version 1.0

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:59 GMT

Technology OverviewDialogueView is a tool for annotating dialogues with utterance boundaries, speech repairs, speech act tags, and discourse segments. The tool provides several views of the data, including a word view that is time-aligned with the audio signal, and an utterance view that shows the dialogue as if it were a script for a play. The utterance view abstracts away from lower level details that are coded in the word view. This allows the annotator to have a simpler view of the dialogue when coding speech act tags and discourse structure, but still have access to the details wh...

Sigma-Point Filter-Based Integrated Navigation System

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:58 GMT

Technology Overview The Wan-Merwe Sigma-Point Kalman Filter (SPKF) is an integrated navigational system that uses nonlinear recursive Bayesian Interference to improve navigational capablities. While improving software for unmanned vehicles, Eric Wan and Rudolph van der Merwe at Oregon Graduate Institute School of Science & Engineering at OHSU developed an improved method for navigation, feedback control, and fault detection applicable to unmanned and manned vehicles. The potential applications include the navigational software in aircraft, helicopters, missiles, cars, trucks, unde...

Design to Learn: Hands-On Learning Posters

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:58 GMT

Technology OverviewHands-On Learning Posters Set of nine 11 x 17 inch different classroom posters used to remind classroom staff which object interaction skills are being targeted for specific students in each activity area. The posters contain the 39 skills from the child skill assessments from Hands-On Learning assessment instrument. Eight posters represent generic activities such as circle time or structured play: the ninth poster is left blank for unique classroom activities. 11 X 17 in., full color, may be laminated for repeated use. To learn more about the posters and or...

Patient Service Portal

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:55 GMT

Technology OverviewSoftware solution using web-based technology that addresses the needs of complex management of servicing patients. This product provides critical information to front line and management staff in a medical office by connecting all relevant available data sources and linking them to one easy to use interface. Specifics addressed are physician practices, ancillary department services, insurance eligibility and benefits, and other important information accessed from an employee's own desktop.

Centralized Geographic and Latency-Based Redirection of Game Players

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:53 GMT

Technology Overview The gaming and entertainment market is one of the fastest growing parts of the Internet. This invention allows game publishers to control how clients connect to servers in a fine-grained manner. The processes can save tremendous amounts in bandwidth and overhead. Currently, each client downloads the global list of servers and individually pings each one. This technology sorts the clients based on centralized geography. The service is fully functional and has been used to redirect over 50,000 Counter-Strike game clients in one month. The target licen...

New selective estrogen receptor modulator (SERM)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:51 GMT

Technology Overview Current hormone replacement therapy involving either estrogen alone or a combination of estrogen and progestin is fraught with serious side effects including increased susceptibility to breast cancer, endometrial cancer, and stroke. A novel SERM designed and synthesized by researchers at OHSU and UCSF has been shown to be devoid of many of the negative side effects arising from peripheral estrogen receptor activation since it does not bind to the classical nuclear estrogen receptors. The action of this compound is restricted to the non-genomic hypothalam...

A Method for Protecting the Internet using TCP and IP Puzzles

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:50 GMT

Technology Overview Denial-of-service attacks are increasing being used by internet hackers trying to disrupt to operations of a targeted company or to draw attention to themselves. One technique for defending against these types of attacks is to use IP puzzles. Previous puzzle mechanisms do not use control feedback in managing the difficulty of the puzzles given to the client. By making puzzles static against load, these mechanisms can either pass back puzzles that are too easy for clients or puzzles that are too hard. In the former case, this renders puzzles ineffective in controll...

Automatic microelectrode recording analysis and visualization for improved target localization

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:48 GMT

Technology Overview This technology is directed at improving visualization of the target location and neuronal structures along the stereotactic trajectory during neurosurgery. For example, in Parkinson's disease patients, visualization and target determination is desirable in order to correctly place the deep brain stimulator electrode or ablate the correct neurons to treat symptoms associated with the disease. The technology is embodied in computer algorithms that can be incorporated into existing neurosurgical workstations so that analysis and visualization are performed at substan...

Moisture control system for heated purge and trap

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:47 GMT

Technology Overview This innovative technology is able to remove up to 98% of the moisture content generated by purge and trap systems during the purging process. Competitive AdvantagesThere are many benefits to this technology, including: · Measuring very water-soluble compounds at low detection limits (the chemical volatility range is expanded with this system) · Lowering or removing common carryover interference for a purge and trap system. The system can remo...

Monoclonal Antibodies to Gonadotropin-Releasing Hormone

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:46 GMT

Technology Overview Biological materials available include the mouse hybridoma cell line producing monoclonal antibody HU11B specific to mammalian gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH). Selected Publications Urbanski H. Monoclonal Antibodies to luteinizing hormone-releasing hormone: production, characterization, and immunocytochemical application, Biol. of Reprod. 1991; 44:681-686.

TOOLKIT from the Center for Spoken Language Understanding

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:46 GMT

Technology Overview Please visit CSLU website to find out more about the CSLU Toolkit, a comprehensive suite of tools to enable exploration, learning, and research into speech and human-computer interaction. The second beta release of the Toolkit has been in use for a little over a year and has seen over 11200 downloads from 100 countries.

ATLAS & ATHENA: Athletes Training and Learning to Avoid Steroids & Athletes Targeting Healthy Exercise and Nutrition Alternatives

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:45 GMT

Technology Overview ATLAS (Athletes Training & Learning to Avoid Steroids) targets male adolescent athletes use of anabolic steroids, alcohol and other drugs and use of sport supplements, while improving healthy nutrition and exercise practices. ATLAS has a team-centered design, which provides a non-stigmatizing atmosphere, such that content can be gender-specific and address etiologies and risks of substance abuse unique to male adolescents. ATHENA (Athletes Targeting Healthy Exercise & Nutrition Alternatives) is a school-based team -centered prevention program for fem...

ReBEL: Recursive Bayesian Estimation Library

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:44 GMT

Technology Overview ReBEL is a Matlab toolkit of functions and scripts, designed to facilitate sequential Bayesian inference (estimation) in general state space models. This software consolidates research on new methods for recursive Bayesian estimation and Kalman filtering by Rudolph van der Merwe and Eric A. Wan. The code is developed and maintained by Rudolph van der Merwe at OGI School of Science & Engineering at Oregon Health & Science University.

Voice Transformation (High Resolution) from the Center for Spoken Language Understanding

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:44 GMT

Technology Overview A good document describing Dr. Kain's method can be downloaded from http://salad.bme.ogi.edu~kain/research/defense/defense.pdf The essence of the system is the following: - Parallel recordings are obtained of a [to-be-transformed] source speaker and a [to-be-mimicked] target speaker. "Parallel" refers to the fact that the exact same text is used. - An automatic alignment system is used to find the correspondence between the phonemes in the two sets of recordings. - The target speaker's speech is analyzed using LInear Predictive Coding, producing LPC coeff...

POMC transgenic mice and neuron-specific promoter

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:41 GMT

Technology OverviewPOMC neurons of the hypothalamus are critical components of the neural circuitry controlling appetite, feeding, and metabolism. In addition they modulate the activity of other hypothalamic neurons which control reproduction, thyroid hormone levels, growth hormone secretion and neuroendocrine stress responses. Genetic evidence in humans implicates the POMC gene in the regulation of weight and fat mass. Researchers at OHSU have identified and characterized a DNA sequence upstream of the mouse POMC gene promoter that is essential for targeting gene expression s...

Multicast Priority Progress Streaming

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:37 GMT

Technology Overview This technology is a derivative of OHSU case # 587 "Priority Progress Streaming" and contains enhancements to enable efficient use of multicast networks. Priority Progress Streaming system is a TCP friendly method to stream highly scalable content over unreserved bandwidth connections. PPS recodes and actively monitors the data stream to ensure that the most important frames arrive first. As the end user (or the network) experiences varied bandwidth availability, the software adapts the stream to ensure the best possible experience possible. Compet...

Blue Violet Phosphor for use in Flat Panel Displays

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:35 GMT

Technology Overview A bright, short wavelength blue-violet phosphor for electroluminescent displays with an alkaline-based halide as a host material and a rare earth as a dopant. The host alkaline chloride can be chosen from the alkaline elements with a europium or cerium rare earth dopant, electroluminesces at a peak wavelenght of 404 and 367 nanometers respectively. The resulting emissions have CIE chromaticity coordinates which lie at the boundary of the visible range for the human eye thereby allowing a greater range of colors for full color flat panel electroluminescent displays....

Multi-Actuator System for Active Sound and Vibration Cancellation

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:32 GMT

Technology Overview A multi-actuator system for sound and vibration cancellation utilizes a LMS type algorithm having an adaptive filter. However, the error signal rather than the input is filtered through an adjoin filter of the error channel to drive an adaptive filter which in turn drives, for example, a loudspeaker to provide destructive interference for noise cancellation. This method significantly decreases computational complexity for multiple-input-output systems.

Atomic Layer deposition of copper films

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:31 GMT

Technology OverviewThis invention relates to a method of depositing an ultra-thin seed layer of copper film on a silicon substrate using Atomic Layer Deposition (ALD). This method uses a carrier gas to deposit a source metal in the presence of a reducing agent so that the rate, temperature and number of phases can be easily controlled. This process may be used for the deposition of conformal seed layers for subsequent electrodeposition of thicker films for microelectronic interconnect applications in state of the art electronic devices. This process can also be reversed ...

Novel Mammalian Catecholmine Receptor Genes and Uses

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:30 GMT

Technology Information This invention encompasses expression of the Trace Amine Associated Receptor 1 (TAAR1) receptor gene in cell culture, and an assay to determine activity of the TAAR1 receptor function in the presence of test compounds. Until now, TAAR1 proteins have been difficult to express and assay in-vitro. The clones and associated methods included in this invention offer a valuable way to test the effects of compounds on the prototypical trace amine receptor. TAAR1 is the first member of a family of G Protein-Coupled Receptor proteins (GPCRs) known as ...

Fibrinogen Gamma' Peptide as an Anticoagulant

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:30 GMT

Technology Overview The anticoagulant (Gammarin) is a synthetic peptide that corresponds in amino acid sequence to the carboxyl terminal 18 amino acids in the g' chain of the blood clotting factor fibrinogen, PEHPAETEYDSLYPEDDL, but contains phosphotyrosine residues in place of the natural sulfotyrosine residues at amino acids 9 and 13 (equivalent to amino acids 418 and 422 in the native g' chain). Gammarin binds to exosite II on thrombin (Lovely 2003; Sabo 2006), similar to heparin, but unlike heparin, Gammarin inhibits the action of thrombin even in the absence of the natural th...

CBP Expression Vector

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:27 GMT

Technology OverviewCyclic AMP-regulated gene expression frequently involves a DNA element known as the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. This modification stimulates interaction with one or more of the general transcription factors or, alternatively, allows recruitment of a co-activator. CREB phosphorylated by protein kinase A binds specifically to a nuclear protein of M(r) 265K which we term CBP (for CREB-binding protein). Fusion of a...

Corticotrophin releasing hormone double receptor (CRH-R1/R2) knockout mice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:24 GMT

Technology OverviewSignaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and pharmacologically distinct corticotropin releasing factor receptor subtypes (corticotropin releasing factor receptor-1 and corticotropin releasing factor receptor-2) have been described. To study the developmental and physiological role of the specific receptor subtypes, a strain of mice null for both the corticotropin releasing factor receptor-1 gene the corticotropin releasing ...

A Japanese Macaque Virus Model for Multiple Sclerosis

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:23 GMT

Technology OverviewMultiple sclerosis (MS) is a chronic, debilitating inflammatory disease limited to the central nervous system (CNS) white matter for which there are very few effective treatments. The inflammatory response in MS is characterized by T lymphocyte-mediated demyelination of the CNS and by autoimmune responses to myelin proteins such as myelin basic protein, proteolipid protein, and myelin oligodendrocyte glycoprotein. There is considerable interest in the investigation of the mechanism of this disease and in the improvement of diagnosis and assessment...

Corticotropin-releasing hormone receptor-2 knockout mice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:20 GMT

Technology Overview Several of the critical molecules that mediate the response to stress have recently been identified and cloned, thus providing new molecular tools for studying this process. One of the primary players in neuro-immune regulation is the neuroendocrine hormone, corticotropin-releasing hormone (CRH). This hormone is the central mediator of the stress response. CRH also regulates the immune response through direct actions on immune cells and indirectly through downstream mediators. Dr. Stenzel-Poore and her colleagues discovered a new receptor for CRH, CRH-R2, which is ...

cDNA Encoding the Cell Surface Receptor that Mediates Infection by Feline Leukemia Virus Type C

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:18 GMT

Technology OverviewFeline Leukemia Virus Type C (FeLV-C) is a class of feline leukemia virus that often occurs in domestic cats and has been associated with moderate to severe aplastic anemia. There are three main types of feline leukemia virus: FeLV-A, FeLV-B and FeLV-C. Diagnostic tests can detect all three types of FeLV but can't distinguish between them. There are two FeLV blood tests that detect antigens to FeLV including: (i) enzyme-linked immunosorbent assay (ELISA); and (ii) immunofluorescence assay (IFA) also called the Hardy, or slide test. The cur...

H9 cell clones susceptible to HIV isolates

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:17 GMT

Technology OverviewOptimal development and evaluation of antiviral drugs and vaccines to HIV depend on cell culture studies using HIV-1 isolates that are representative of patient viruses. Many of the early HIV-1 isolates used were laboratory adapted strains which grew well in leukemic T cell lines such as H9. However, it was later realized that these laboratory adapted strains were different from primary patient isolates, and HIV-1 isolates from patients grow poorly in leukemic T cell lines. In order to overcome this hurdle, several derivatives of the H9 cell line were genera...

D2 Dopamine Receptor Knock-Out Mice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:07 GMT

Technology OverviewD2R is the gene for the D2 dopamine receptor and encodes a member of the D2-like class of dopamine receptors. It is one of the most abundant dopaminergic receptors expressed in the brain. This strain could be used to screen and assess agonist and antagonist drugs specific to the D2 receptor. These mutant mice could also provide a novel experimental system with which to study the role of dopamine in numerous brain functions, CNS-related diseases, addiction, depression, and anxiety-related disorders. They provide an excellent model for Parkinson’s disease.&n...

Putative Mammalian Catecholamine Receptor (p-Tyramine-R)(TAR)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:06 GMT

Technology Overview This invention encompasses expression of the Trace Amine Associated Receptor 1 (TAAR1) receptor gene in cell culture, and an assay to determine activity of the TAAR1 receptor function in the presence of test compounds. Until now, TAAR1 proteins have been difficult to express and assay in-vitro. The clones and associated methods included in this invention offer a valuable way to test the effects of compounds on the prototypical trace amine receptor. TAAR1 is the first member of a family of G Protein-Coupled Receptor proteins (GPCRs) known as the...

D4 Dopamine Receptor Knock-Out Mice

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:30:05 GMT

Technology OverviewResearchers at OHSU have developed a strain of mice that are genetically deficient in the D4 dopamine receptor. These mice provide a new animal model for the study of the function of the D4 receptor. Homozygous mice may exhibit locomotor supersensitivity to ethanol, cocaine, and methamphetamine, as well as alterations in dopamine synthesis and function, glutamate levels and metabolism, behavioral responses to novelty, and spontaneous locomotor activity in both novel and familiar environments. They can also be used to study the actions and specif...

Opioid Antagonists and Methods of Their Use (Orphanin & analogs)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:52 GMT

Technology Information Technology 0349 relates to a novel mammalian anti-opioid receptor protein (OFQR), peptide ligands (such as OFQ) that bind to OFQR, and methods of using the OFQ peptide and analogues to reverse the physiologic effects of opiates such as morphine. The isolation, characterization and pharmacological use of the endogenous peptide ligand is described. A particular embodiment of the OFQ peptide is a heptadecapeptide having an FGGF aminoterminal motif. The peptide specifically binds to an OFQ receptor protein heterologously expressed in mamma...

Mammalian Opioid Receptor Ligand and Uses (Orphanin FQ)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:50 GMT

Technology Information Technology 0346 relates to a novel mammalian opioid receptor protein and ligands that bind to such proteins. The invention is directed toward the isolation, characterization and pharmacological use of an endogenous ligand that specifically binds to a novel mammalian opioid receptor protein heterologously expressed in mammalian cells. The invention specifically provides the isolated peptide ligand and analogues, derivates and variants thereof. The invention specifically provides tyrosine substitution variants of the peptide ligand that spec...

cDNA Clone Encoding an Expressible GABA Transporter

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:45 GMT

Technology Overview DNA molecules encoding a GAT-B transporter activity are disclosed. The GAT-B activity is sensitive to -alanine, is expressed predominantly in neurons, and exhibits other characteristics distinguishing it from other GABA transporter activities. Also disclosed are cloned cDNAs encoding GAT-B activity that can be incorporated into expression vectors and used to transfect various types of cells; the nucleotide sequence of GAT-B cDNA; an amino acid sequence of the GAT-B protein; nucleotide sequences complementary or substantially homologous to e...

D1 Cloned Genes Encoding Dopamine Receptor

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:43 GMT

Technology Information Cloned genes which code for the D1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profiles and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D1- dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D1-dopamine receptor. The cloned g...

A Novel Human Dopamine Receptor and its Uses (D4 subtypes - D4.2,4.4,4.7)

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:42 GMT

Technology OverviewTechnology 0250 is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and allelic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and metho...

D4 Cloning of a Human Dopamine Receptor

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:42 GMT

Technology Overview Technology 0199 is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor is provided by the invention. The invention also includes a recombinant eukaryotic expression vector capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor.

A Novel Adenosine Receptor (A3) and Uses

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:40 GMT

Technology OverviewTechnology 0223 relates to a novel mammalian adenosine receptor. The invention is directed toward the isolation, characterization and pharmacological use of the rat A3 adenosine receptor, the gene corresponding to this receptor, recombinant eudaryotic expression construct capable of expressing the rat A3 adenosine receptor in cultures of transformed eukaryotic cells that synthesize the rat A3 adenosine receptor. The invention also provides methods for screening adenosine-receptor agonists and antagonists in vitro using preparations of the rat A3...

D2 Dopamine Receptor and Genes and Associated United States Patents

dincherk@ohsu.edu — Wed, 28 Apr 2010 15:29:39 GMT

Technology Overview Researchers at OHSU have cloned the D2 Dopamine receptor, and have developed cell lines containing both the D2 short and long forms, which are useful in studying ligand-receptor interactions, and developing potential drug candidates for treatment of neurological diseases. Currently, the university holds numerous patents covering the gene and protein sequences encoding for this receptor and its use as a target for drug development purposes, as well as methods for preparing labeled or unlabeled species for research and development. Dopamine receptors have ke...

HeLa cell clones highly susceptible to all isolates of HIV-1 and useful for titering HIV-1 isolates.

dincherk@ohsu.edu — Tue, 27 Apr 2010 17:34:45 GMT

Technology OverviewThis technology is a single clone line of adherent cells that are susceptible to both T-cell trophic HIV1 isolates and Macrophage-trophic HIV-1 isolates. It has utility in determining HIV co-receptor usage, discovery of new drugs effective against HIV and in monitoring drug therapy protocol to enhance the effectiveness of drug treatment regimes against HIV-1 infection. Cell clones are available that express discrete and different quantities of CD4 or CCR5. By measuring titers in the different clones in the presence or absence of test entry inhibitors or antibodies, ...

Bacterial Hemoglobin Receptor Genes and Their Uses in Therapeutics and Diagnostics

dincherk@ohsu.edu — Tue, 20 Apr 2010 14:34:23 GMT

Technology Overview Bacterial pathogens require exogenous iron to survive in their hosts, and withholding iron is one of the nonspecific, but highly successful strategies developed by the host to combat bacterial infections. Bacteria acquire iron from the host due to the presence of outermembrane proteins that bind host iron containing compounds such as transferrin, lactoferrin and various heme containing compounds. One of these outermembrane proteins, the hemoglobin receptor, has been cloned from N. meningitidis. The gene for this receptor is present in singl...

Bacterial Hemoglobin Receptor Genes and Their Uses in Therapeutics and Diagnostics

dincherk@ohsu.edu — Tue, 20 Apr 2010 14:34:23 GMT

Glutathione Detection

iia@pdx.edu — Thu, 15 Apr 2010 12:25:01 GMT

Robert Strongin and his lab focus on dyes and fluorescing compounds for use in a variety of applications. Recently, they have developed new compounds for the colorometric detection of glutathione. The compounds are useful in detecting thiols generally, but can also be used to selectively detect glutathione, cysteine, and homocysteine. Current reported methods for thiol detection rely on non-specific redox chemistry, immunoassays, or derivitization with chromophores or fluorophores. These compounds meet a substantial need for detecting and distinguishing betw...

Single Particle Quantum Dot Imaging Achieves Ultrasensitive Detection Capabilities for Western Immunoblot Analysis

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:19 GMT

Technology Overview Single particle quantum dot (SPQD) imaging enables ultrasensitive detection for Western immunoblot analysis. This technology substantially improves detection methods of samples present at trace concentrations in complex biological sample matrices. Western immunoblot is a low-cost and simple technology used in biomedical laboratories for detecting cellular proteins, such as HIV core proteins and other infectious biomolecules. Western immunoblotting faces significant limitations in detection sensitivity, making it difficult or impossible to use in situations ...

Ultrasound Based Approach to Diagnosing Heart Failure

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:19 GMT

Technology Overview Right ventricular (RV) function has prognostic significance in heart failure, and RV dysfunction has been shown to predict reduced exercise capacity and survival. Current non-invasive methods to evaluate RV function include echochardiography (the most common), MRI, high frequency thermodilution, contrast ventriculography, and radionucleotide entriculography. However, none of these techniques have proven to be a reliable and validated method for determining RV function. OHSU has a developed a novel, non-invasive, ultrasound image software an...

Profiling circulating fragments of fibrillin-1, fibrillin-2, and fibulin-4 as biomarkers for disease

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:18 GMT

Technology Overview Fibrillin-1, fibrillin-2, and fibulin-4 are molecular components of elastic fibers and microfibrils. Elastic fibers and microfibrils are stable structures especially abundant in the connective tissues of blood vessels, lung, skin, ligaments and tendons, and the eye. As a result of disease processes, these structures can be degraded by proteases. Examples of diseases that exhibit degradation of elastic fibers and microfibrils are Marfan's syndrome (a heritable disorder of connective tissue affecting 1 in 5,000), aortic aneurysm and aortic dissection (major health is...

Methods for non-invasive monitoring of blood glucose concentration

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:15 GMT

Technology Overview The yearly worldwide market for glucose testing is estimated at $4 billion and is growing at an annual rate of 12 to 18 percent. Unfortunately, an estimated 80 percent of diabetics do not monitor themselves even once a day and suffer from complications such as kidney disease, blindness, neuropathy and increased risk of heart disease. The occurrence of these complications can be significantly reduced by actively monitoring glucose levels. The current standard for monitoring blood glucose levels involves painful “finger sticks”, an invasive process even with r...

MRI measured markers for tumor malignancy determination

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:15 GMT

Technology Overview Magnetic Resonance Imaging (MRI) provides much greater contrast between soft tissues of the body than computed tomography (CT), making it especially useful in neurological (brain), musculoskeletal, cardiovascular and oncological (cancer) imaging. However, MRI can suffer from a high false positive rate for tissue differentiation analysis due to how the injected contrast reagent is interpreted in the images. OHSU has developed a novel solution for more accurately detecting MRI contrast reagent in DCE MRI which provides for greater differentiation of tissue. MRI ...

Computational Model Analysis of I/V Relation Currents of Vascular Cells

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:14 GMT

Technology Overview This Computational Model Analysis of I/V Relation Currents of Vascular Cells provides rapid and improved data analysis of drug candidates in a single whole cell electrophysiology experiment. Ion channels represent an important drug target class, yet high-throughput electrophysiological screening techniques for simultaneous monitoring of drug action on multiple receptors ceases to exist in industry. The development of anti-hypertension and other cardio vascular drugs often requires complete profiling of the compounds cellular actions. Because drugs often interac...

Novel location, novel object recognition test for use in children and the elderly

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:08 GMT

Technology Overview Note: The summary for this technology includes information for related case 1190. Memory Island and Novel Image Novel Location (NINL) are computer-based tests that diagnose the early onset of cognitive decline and dementia, such as that associated with Alzheimer’s disease (AD). Testing and diagnosis provided by Memory Island and NINL software are also important in patients who may not yet exhibit obvious symptoms, but have risk factors for the disease, such as age and family history. These tests also provide a quantifiable result for measurement of disease progre...

Memory Island spatial navigation test for use in children and the elderly

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:08 GMT

Technology Overview Note: The summary for this technology includes information for related case 1191. Memory Island and Novel Image Novel Location (NINL) are computer-based tests that diagnose the early onset of cognitive decline and dementia, such as that associated with Alzheimer’s disease (AD). Testing and diagnosis provided by Memory Island and NINL software are also important in patients who may not yet exhibit obvious symptoms, but have risk factors for the disease, such as age and family history. These tests also provide a quantifiable result for measurement of disease progr...

Contrast-Enhanced Magnetic Resonance Imaging for Detection and Quantification of Fibrosis in Human Myocardium

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:07 GMT

Technology Overview Myocardial fibrosis is a morphologic change common to multiple cardiac disease conditions. In addition to replacement (scar) fibrosis, there is increasing recognition of interstitial (reactive) fibrosis acting as an important player in structural remodeling of the diseased heart, as well as the genesis of fatal arrhythmia leading to sudden cardiac death. OHSU has developed a novel, non-invasive, imaging-based test to analyze diffuse fibrosis to determine the global fibrosis burden on the heart. OHSU’s unique software techniques, in combination with D...

A Method for Separation and Identification of Proteins Using Unconventional Gel Electrophoresis and Nanoparticle Quantum Dot Tags

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:23:00 GMT

Technology OverviewOHSU researchers have developed a method which uses Quantum Dots (QD) to separate and image targeted proteins in live cells. The recent, rapid success of QDs for imaging cells and tissues in a variety of cellular systems and imaging modalities indicates the versatility and potential of this nanotechnology to contribute to biomedicine. Quantum dots are fluorescent semiconductor nanoparticles with novel optical capabilities that allow for ultra-sensitive detection of single QDs with a simple fluorescence illumination-detection source. QDs can be used as a substitute...

In vivo full range complex Fourier domain optical coherence tomography

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:22:59 GMT

Technology Overview OHSU has developed technology for optical coherence tomography (OCT) imaging that extends OCT’s depth imaging range, enables real time flow imaging, and further enables optical coherence angiography. In vivo three-dimensional mapping of biologic tissue and vasculature is a challenging proposition due to the highly-scattering and absorptive nature of biologic tissue. Some current imaging methods have slow scanning speeds making in vivo three-dimensional imaging difficult. Other techniques having faster scanning speeds are not able to scan deeply into ...

Method and device for non-invasive analyte measurement

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:22:57 GMT

Technology Overview People with diabetes can significantly reduce the risk of complications associated with disease by actively monitoring their blood glucose levels. The current standard method of monitoring blood glucose levels involves painful finger sticks and many diabetic patients fail to actively manage their glucose levels for the primary reasons of finger soreness, pain, inconvenience, and fear of needles. Researchers have been searching for ways to noninvasively measure blood glucose in diabetic subjects for years. This research has commonly taken one of two approaches:...

Real-Time Non-Invasive Tracking of Moving Lung Tumors in Radiation Therapy of Lung Cancer

dincherk@ohsu.edu — Thu, 08 Apr 2010 16:22:56 GMT

Technology Overview Respiratory motion in the thorax and abdomen limit our ability to deliver radiation accurately and effectively during radiation treatment of lung tumors. The goal, therefore, was to develop technology to enable effective and accurate management of respiratory motion for radiation therapy of lung cancer using noninvasive sensory means and advanced statistical signal processing techniques. Using a mixture of non-invasive imaging sensors already on the market and proven statistical modeling and estimation techniques, Dr. Song is recruiting volunteer subjects, pilot ...

Enhanced Lysozyme For Wine

mary.foley@oregonstate.edu — Fri, 26 Mar 2010 16:32:00 GMT

In winemaking it is desirable to control or eliminate bacteria that may spoil wine by the production of off flavors, off aromas, loss of texture and haze formation. Dr. Mark Daschel and Dr. James Kennedy have discovered a new method that decrease the interaction between tannins found in wine and lysozome added to wine as antimicrobial agent, for example by adding a tannin-binding agent to the wine prior to adding lysozome to the wine. This method increases lysozome antmicrobial activity in the wine, since lysozome bound to tannin in not available for providing antimicrobial act...

Curriculum for HR Professionals to Support Employees with Children with Disabilities

iia@pdx.edu — Tue, 23 Mar 2010 15:16:44 GMT

Human Resources professionals sometimes lack knowledge in how best to provide support for their employees who have children with special needs. As this population of employees increases, more training and resources are needed. PSU's team from the Regional Research Institute has created and tested a set of effective materials for use with Human Resources professionals.

Use of PPR 10 as a Regulatable Switch for Expression of Transgenes in Chloroplasts

techtran@uoregon.edu — Thu, 18 Mar 2010 14:21:01 GMT

There is considerable interest in using plants for the expression of recombinant proteins for pharmaceutical and other purposes. Although recombinant proteins can be expressed by insertion of transgenes into the nuclear genome, expression from the chloroplast genome offers significant advantages, including high level of transgene expression and lack of gene silencing and position effects. Most importantly, chloroplasts in many species are not transmitted through the pollen, thereby reducing concerns about transgenes accidentally spreading to other plants. Because ectop...

CORPORA from CSLU Portland cellular v1.3

dincherk@ohsu.edu — Fri, 19 Feb 2010 09:56:42 GMT

The Portland Cellular Corpus v1.3 consists of utterances gathered from callers who were using cellular telephones. Each participant called a toll-free cellular number, then listened and responded to the protocol. A total of 515 different callers participated. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place your order: 1. Click on the t...

Improved Permanent-Magnet, Helical Screw Drive (PMHSD)

mary.foley@oregonstate.edu — Thu, 11 Feb 2010 11:52:10 GMT

Oregon State University is seeking a company interested in the manufacture and commercialization of a state-of-the-art linear actuator system using a permanent magnetic system. The use of magnets for force coupling allow for watertight and airtight transmission or force that lends itself well to underwater, fowl weather, chemically sensitive, or radiation area applications. Applications Uses Include: - lower thrust hydraulic ram replacement, - pneumatic cylinder rep...

PVP Potato [Crimson Red]

mary.foley@oregonstate.edu — Thu, 11 Feb 2010 11:29:51 GMT

Crimson Red is available through the Potato Variety Managment Institute, Inc. Please go to http://www.pvmi.org for more information about license details.

PVP Potato [Red Sunset]

mary.foley@oregonstate.edu — Thu, 11 Feb 2010 11:29:50 GMT

• High Fresh Market Quality • High MarketableYield • Few Tuber Defects • Bright Red SkinColor • High Vitamin C Content Red Sunset is available through the Potato Variety Management Institute, Inc. Please visit www.pvmi.org for license details.

Chlamydia Trachomatis Genomic DNA Fragments Encoding Novel Vaccine Candidates For Prevention Of Chlamydial Diesase

mary.foley@oregonstate.edu — Thu, 11 Feb 2010 11:29:46 GMT

The invention relates to the detection of Chlamydia and to the diagnosis, treatment and prevention of Chlamydia infections in animals. The invention includes the use of Chlamydia proteins that show enhanced expression in the reticulate body (RB) stage relative to the elementary body (EB) stage of the Chlamydia life cycle. These proteins are not present at detectable levels in the EB form using current immunological techniques and are thus said to be "infection-specific." Certain of these infection-specific proteins are found in the inclusion membrane of the infected cell, and so have b...

PVP Potato [Russet Legend]

mary.foley@oregonstate.edu — Thu, 11 Feb 2010 11:29:46 GMT

Russet Legend is available through the Potato Variety Management Institute, Inc. Please go to http://www.pvmi.org for more information about license details.

Algorithm For Automated Detection of Melanoma

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:25 GMT

Technology Overview Comprehensive diagnosis of melanoma typically requires both reliable histopathology and the trained eye of a clinician for assessment. With optical (as opposed to physical) sectioning of tissue and OHSU created software to process confocal images, it is possible to distinguish the diagnostic traits of malignancy, such as the presence of pagetoid melanocytes in the epidermis and the breakdown of the dermal-epidermal (DEJ), without biopsy. There is a pressing need for better diagnostic tools for the diagnosis of skin lesions suspected to be cancerous. &nb...

Confocal Pathology Apparatus

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:24 GMT

Technology Overview Several surgical procedures to remove tumors involve detection of aberrations of cell morphology that are impossible to discern with the unaided eye. In such circumstances, surgeons perform successive incremental excisions and each sample of excised tissue is subjected to histological examination to determine the remaining extent of the tumor. This procedure for preparing the histology sections is tedious and time consuming, often exceeding 30 minutes per section. In turn, surgical procedures that rely on such histology sections can extend to two hours and...

Monoclonal Antibody with Applications in Pancreatic Adenocarcinoma Detection, Diagnosis and Disease Monitoring

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:24 GMT

Technology Overview:The current diagnosis of pancreatic adenocarcinoma is made using CT scanning, endoscopic ultrasound, and fine needle biopsy of the pancreatic lesion. Unfortunately, these tests are indeterminate approximately 30% of the time. The treatment for early pancreatic cancer (including indeterminate cases) is a long surgery with a high rate of morbidity. Thus, there is significant need for highly specific diagnostic tests that will allow accurate detection of early pancreatic cancer. At present, there are no reported monoclonal antibodies that effectively differentiate bet...

Monoclonal Antibodies that React with Cell Surface Molecules on Human Pancreatic Duct Cells, Endocrine (Islet) Cells, Exocrine Cells and Alpha Cells

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:19 GMT

Technology OverviewDiabetes is a common disease affecting millions of individuals in the United States. Type 1 diabetes occurs when pancreatic islet beta-cells are destroyed as a consequence of an autoimmune disorder. Despite improvements in the medical management of diabetes, severe complications and shortened life-span are still common in individuals with this disease. Cell replacement therapy can work in type 1 diabetes as shown by the success of islet transplantation from cadaveric donors in the Edmonton protocol. Unfortunately, the supply of transplantable ...

Gene Polymorphisms Associated with Increased Risk of Hyponatremia

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:15 GMT

Technology Overview: This technology provides methods of diagnosing an increased risk for hyponatremia by assessing the presence of at least one hypofunctioning allele of TRPV4. Abundant evidence suggests that the transient receptor potential channel TRPV4 comprises an element of the central sensor of low osmolality. A large cohort of patients have been genotyped for the polymorphic allele and its presence is over-represented in those subjects with the lowest serum sodium concentrations and who are the greatest risk of developing hyponatremia. This diagnostic can identify a subset of ...

Humanized T cell hybridoma specific for myelin oligodendrocyte glycoprotein 35-55 peptide from HLA-DRB1*1501-transgenic mice and its application

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:14 GMT

Technology OverviewThis hybridoma offers a laboratory tool to identify, screen, and characterize T-cell immune modulatory agents for use in treating patients with immune disorders including multiple sclerosis. This technology describes a T cell hybridoma specific for, and reactive to, human myelin oligodendrocyte glycoprotein (MOG)-35-55. The T-cell hybridoma is positive for D3(+) and CD4(+) cells and negative for CD8(-) cells, expresses TCR BV8/AV11 and AV17 genes, and produces IL-2, IFN-y and TNF-a Th1 cytokines upon concanavalin A or MOG peptide stimulation. The MOG-35-55 pe...

Methods of selecting T cell receptor V peptides for therapeutic use

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:12 GMT

Technology OverviewTechnology 0618 represents a method to identify a T cell receptor (TCR) peptide for use as a therapeutic agent in patients with autoimmune diseases. Regulatory T cells are generated that can inhibit the activation of inflammatory cells involved in autoimmune diseases to be used as a treatment for subjects. Methods are also disclosed for selecting a therapy for a subject after identification of a TCR in a particular subject.Multiple sclerosis (MS) is a disabling disease affecting the central nervous system. As the disease progresses, patients require more care while...

Melanocortin-3 Receptor Knockout Mice

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:12 GMT

Technology OverviewThe central melanocortin system is critical for the long term regulation of energy homeostasis. Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, obesity, and accelerated longitudinal growth in mice and humans. To assess the role of the melanocortin-3 receptor (MC3-R) in energy homeostasis, the mc3r coding sequence was deleted from the mouse genome. In contrast to the MC4-R knockout, which exhibits increased food intake, increased somatic growth, and defects in metabolism, mc3r-/-mice exhibit an exclusively metabolic syndrome. Ho...

Induction of Apoptosis and Cell-Growth Inhibition by Protein 4-33

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:12 GMT

Technology Overview Insulin-like growth factor binding protein 3 (IGFBP-3), a member of the IGFBP superfamily and the most abundant binding protein in human serum, is recognized to play an important role in growth regulation of cancer cells. There is strong evidence showing the inhibitory action of IGFBP-3 on the growth of various tumors, including breast, cervical, lung, non-small cell lung, colon and prostate. This invention covers the identification and characterization of a novel protein, Protein 4.33, that interacts specifically with IGFBP-3 and such interaction is an i...

Mammalian cell lines expressing stably transfected somatostatin receptor SSTR2

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:11 GMT

Technology Overview Somatostatin exerts multiple effects throughout the body by binding to specific somatostatin receptors. Two classes of somatostatin receptors (SRIF1 and SRIF2) had been distinguished biochemically and physiologically. cDNAs for two different rat somatostatin receptors have been characterized, inserted into expression vectors, and each stably transfected into CHO-K1 cells. The cell lines, expressing either SSTR1 or SSTR2, but not both, respond physiologically to somatostatin by inhibition of adenylyl cyclase activity by a pertusis-sensitive pathway. The rat somatost...

Mouse Mlh-1 (-/-) Embryonic Cell Line

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:11 GMT

Technology Overview Mutations in the DNA mismatch repair pathway have been shown to be involved in the development of certain cancers, most notably those of the colon and endometrium. MLH1 is one of the genes involved in DNA repair during cell division. MLH1 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for oncology. Licensing and collaborative research opportunities exist with respect to these biological materials. Market Summary · MLH1 defic...

Mlh1-Deficient Mice

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:11 GMT

Technology OverviewMutations in the DNA mismatch repair pathway have been shown to be involved in the development of certain cancers, most notably those of the colon and endometrium. MLH1 is one of the genes involved in DNA repair during cell division. MLH1 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for oncology. Licensing and collaborative research opportunities exist with respect to these biological materials. Market Summary - MLH1 deficiency results in increased spontaneous mutations t...

Mammalian cell lines expressing stably transfected somatostatin receptor SSTR1

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:09 GMT

Mitogen-Activated Protein Kinase Phosphatase, MKP-2, Gene and Protein

dincherk@ohsu.edu — Wed, 10 Feb 2010 11:07:08 GMT

Technology OverviewMitogen-activated protein kinases (MAP kinases) mediate multiple cellular pathways regulating growth and differentiation. Activation of MAP kinase involves specific phosphorylation events of multiple residues. It has also been shown that inactivation of MAP kinase is a critical event that regulates the physiological response to MAP kinase activation. This inactivation is mediated, in part, by dephosphorylation of MAP kinases by dual specificity phosphatases called MAP kinase phsphatases (MKPs). This invention covers the complete nucleotide and...

Plasmid IE86kd able to produce the human CMV IE86 protein

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:56 GMT

Technology OverviewPlasmid IE86kd has been generated which can be utilized to produce the full length human cytomegalovirus (CMV) IE86 protein. PublicationsJupp R., Hoffmann S., Depto A., Stenberg R.M., Ghazal P., Nelson J.A. Direct interaction of the Human Cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box. J. Virology 1993 Sept;67(9):5595-5604. Licensing OpportunityThe plasmid is available for non-exclusive licensing.

Murine Model System for Human Cytomegalovirus Latency and Pathogenesis

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:55 GMT

Technology OverviewHuman cytomegalovirus (HCMV) is an important ubiquitous pathogen that is a leading viral cause of birth defects and a significant problem in bone marrow transplant patients as well as individuals receiving cancer therapy. Approximately 1 in 750 children born with or develops permanent disabilities due to HCMV. Approximately 8,000 children each year suffer permanent disabilities caused by HCMV. Infection with HCMV is a major cause of disease and death in immunocompromised patients, including organ and bone marrow transplant recipients, hemodialysis pati...

Non-Human Primate Model for Stroke

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:55 GMT

Technology OverviewThe current technology describes a stroke model in the rhesus macaque. The current transorbital approach to model stroke is one that has been successfully used in macaques, squirrel monkeys and baboons with some unique procedural modifications in the current model. Knowledge of the vascular incongruity in rhesus macaques compared to humans led these researchers to test this new model of arterial occlusion. Strokes in non-human primate models would mimic the human condition more closely if they were located in the cortex of the brain. The cur...

SK3 Floxed Allele Mice (SK3 Null Mice)

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:54 GMT

Technology Overview In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. Previously, Dr. Adelman's lab developed transgenic mice overexpressing the SK3 gene (OHSU Tech ID #515). In this invention, a new mouse model was developed which maintains wild-type expression levels while allowing...

Small-Conductance CA2+-Activated Potassium Channel 2 (SK2) Transgenic Mice

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:54 GMT

Technology OverviewIn excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. In this invention, homologous recombination was used to floxed the SK2 gene in mouse ES cells. Subsequent routine manipulations generated homozygous floxed mice. These have been crossed to a series of Cre mice that g...

Small-Conductance CA2+-Activated Potassium Channel 1 (SK1) Transgenic Mice

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:54 GMT

Technology OverviewIn excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. In this invention, homologous recombination was used to floxed the SK1 gene in mouse ES cells. Subsequent routine manipulations generated homozygous floxed mice. These have been crossed to a series of Cre mice that generate...

Small-Conductance Ca2+-Activated Potassium Channel 3 (SK3) transgenic mice

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:52 GMT

Technology Overview In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. In this invention, the SK3 gene was targeted by homologous recombination for the insertion of a gene switch that permits experimental regulation of SK3 expression while retaining normal SK3 promoter function. SK3 transgeni...

U87MG Cell Lines Expressing CD4, CD4 and CCR5, or CD4 and CXCR4

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:51 GMT

Technology OverviewHIV-1 isolates infect cells that express CD4 as well as a coreceptor. The predominant coreceptor for T-cell-tropic isolates is CCR5. Human astroglioma U87MG cells lack coreceptors for HIV-1, so that even U87MG-CD4 cells are resistant to infection. U87MG-CD4/CXCR4 and U87MG-CD4/CCR5 cells were prepared by transfection of a U87MG-CD4 cell clone with pcDNA3 vectors that contained cDNAs for CXCR4 or CCR5. The U87MG-CD4/CXCR4 cells are highly susceptible to T-cell-tropic HIV-1 isolates, whereas the U87MG-CD4/CCR5 cells are susceptible to macroph...

Mouse PMS-2 (-/-) Embryonic Cell Line

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:51 GMT

Technology OverviewMutations in the DNA mismatch repair pathway have been shown to be involved in the development of certain cancers. PMS2 is one of the genes involved in the DNA mismatch/repair pathway. PMS2 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for oncology. Licensing and collaborative research opportunities exist with respect to these biological materials. Background PMS2 protein is part of a repair complex that includes MLH1. Phenotype of the mice suggest that this gene might be i...

Pms-2 Knockout Mouse

dincherk@ohsu.edu — Thu, 28 Jan 2010 13:31:50 GMT

Yeast expressing human VDAC isoforms

dincherk@ohsu.edu — Wed, 27 Jan 2010 14:08:25 GMT

Technology OverviewThe voltage dependent anion channel (VDAC) proteins are the major pathways for metabolite flux through the outer membrane. These mitochondrial membrane proteins control the flux of anions through voltage gated mechanisms. VDACs have been shown to be important in apoptotic responses and linked to certain neurodegenerative diseases. In order to study Human voltage dependent anion channels (HVDACs) these investigators have developed yeast strains expressing HVDAC1 and HVDAC2. These strains can be used for screening small molecules against the HVDACs i...

Mouse lines for the conditional elimination of the expression of the peripheral benzodiazapine receptor

dincherk@ohsu.edu — Wed, 27 Jan 2010 13:27:26 GMT

Technology OverviewThe peripheral benzodiazepine receptor (PBR) is an 18 kDa, highly hydrophobic protein located in the outer mitochondrial membrane that was initially identified as a binding site for benzodiazepines in tissues that lack GABA receptors, the clinical target of benzodiazepines in the central nervous system. Mouse lines have been generated in which the gene encoding PBR (Tspo) contains loxP sites for conditional elimination of PBR expression using widely available genetic strategies. Market SummaryThrough the years, the PBR has been proposed to play a key role in the...

Antiviral Drug Discovery for AIDS: The HIV-1 Vif Protein

dincherk@ohsu.edu — Wed, 27 Jan 2010 13:27:02 GMT

Technology OverviewDespite remarkable medical advances, the incidence of HIV infections continues to rise throughout the world. The majority of current HIV therapies target HIV reverse transcriptase or protease, but viral resistance and toxicity have created a need for more potent and safer therapies against different viral targets. Virion infectivity factor (Vif) is a regulatory protein produced by lentiviruses (HIV-1, HIV-2, SIV, FIV and others). Vif targets the human DNA-editing enzyme, APOBEC3G, a host defense factor which inhibits viral replication. Vif binds to...

Think and Link: Email for Individuals with Cognitive Disabilities

techtran@uoregon.edu — Sat, 19 Dec 2009 13:56:57 GMT

Think & Link is a Java (Swing/JavaMail) mail application with an interface designed for users who have limited memory and skill acquisition abilities. For more information about the Think & Link project, and subsequent work at the University of Oregon to help those with cognitive impairments, please go to http://www.think-and-link.org/ Go to the Office of Technology Transfer

Viscoelastic Thermal Compression of Wood

mary.foley@oregonstate.edu — Wed, 25 Nov 2009 09:02:53 GMT

This patented process and apparatus provides a methodology for converting wood products made from low density wood (e.g. veneer and composite panels) into high density laminae with high levels of strength, stiffness, and dimensional stability. The method uses a combination of steam, heat and mechanical compression that has been termed Viscoelastic Thermal Compression. The "green revolution" has increased public awareness regarding the efficient utilization of timber, and protection of forest lands, particularly the old growth forests. As a result, a shift in the available re...

Methods and Apparatus for Joint Laxity Measurements

mary.foley@oregonstate.edu — Wed, 25 Nov 2009 09:02:47 GMT

The evaluation of joint function is important in the assessment, diagnosis, and treatment of injuries and diseases that affect joint function. Typical methods of evaluation rely on a displacement of a limb by a clinician or physician who applies a force to produce the displacement. The usefulness of such methods of evaluation is limited because of the subjective nature of both the force and the displacement measurements, and meaningful comparisons of measurements by different clinicians/physicians or of measurements before and after therapy are not possible. As a result, such measureme...

Changing Brains: Effects of Experience on Human Brain Development

techtran@uoregon.edu — Tue, 27 Oct 2009 15:09:59 GMT

Changing Brains is an educational DVD program for anyone involved in child rearing, from parents to teachers to policy-makers. Created for non-scientists, Changing Brains features information and practical recommendations based on scientific evidence regarding cognitive development as a child grows. Viewers learn about the brain, how it develops, the methods used to study its structures and function, and how experience shapes the brain. The information provided is supported by evidence from solid scientific studies, and each segment includes a mention of the brain f...

RF Energy Harvesting Circuits

mary.foley@oregonstate.edu — Wed, 30 Sep 2009 12:11:00 GMT

This invention proposed a circuitry systems and techniques for obtaining, recovering, acquiring and/or harvesting electrical energy from an environment having/including radio frequency (RF) signals (for example, signals in the frequency or rate of oscillation within the range of about 3 Hz and about 30 GHz). These new designed systems will allow RF powered devices be used in ultra-low power sensor networks, for example, in remote areas that eliminates the need for batteries in the sensor system and keeps the sensor network free of maintenance Advantages · ...

Aerogel Insulation

mary.foley@oregonstate.edu — Wed, 30 Sep 2009 12:10:57 GMT

Small-Scale Solid Oxide Fuel Cells operate at temperatures exceeding approximately 500 C. Large Scale systems generate enough heat so that heat rejection to the environment is a major design challenge. However, small scale SOFC because of their high surface area-to –volume ratio needs thermal management techniques that restrict the loss of heat to the environment. High performance insulation material is one of several methods that must be used to manage heat loss from the small SOFC package size. The development of this invention is that it allows small business package sizes that inc...

MEMS-Based Fuel Cell

mary.foley@oregonstate.edu — Wed, 30 Sep 2009 12:10:56 GMT

This invention describes the fuel cell architecture and the means to fabricate this architectore that would likly result in a high performance micro-fuel cell. The use of MEMS-based fabrication techniques for the manufacture of fuel cells offers the promise of increased performance out of a small package. Performance parameters in this context include power density (power per unit cell area), specific energy (energy per unit mass), efficiency (electrochemical and fuel utilization), operating temperature reduction, cost and possible integration with control and feedback electroni...

SOFC Anode

mary.foley@oregonstate.edu — Wed, 30 Sep 2009 12:10:56 GMT

Prior solutions require maintaining fuel flow while shutting down the air from first to the fuel cell during shutdown. This leads to a loss of fuel during shutdown of the fuel cell operation. During the shutdown, air flowing into the combustion chamber can flow into the anode of the fuel cell. A simple way of preventing this is to place check valve between the SOFC anode and the combustion chamber. This check valve will prevent flow of air from the combustion chamber into the anode side of the SOFC. Advantages: This invention reduces fuel requirements for the operations/shutdown...

Improved Multiplication

mary.foley@oregonstate.edu — Wed, 30 Sep 2009 12:10:55 GMT

Multi-precision multiplication methods over GF(2.sup.m) include representing a first polynomial and a second polynomial as an array of n words. A recursive algorithm may be used to iteratively decompose the multiplication into a weighted sum of smaller subproducts. When the size of the smaller subproducts is less than or equal to a predetermined size, a nonrecursive algorithm may be used to complete the multiplication. The nonrecursive algorithm may be optimized to efficiently perform the bottom-end multiplication. For example, pairs of redundant subproducts can be identified and excl...

Multiscale Transport Apparatus And Methods - Thermal Management Devices

mary.foley@oregonstate.edu — Wed, 30 Sep 2009 12:10:54 GMT

The Multi-Scale Transport and Reaction Enhancement Device (MTRED) is an apparatus designed to maximize the efficiency of transport processes. These include mass, momentum and energy transport with specific possibilities for enhancing bio and catalytic reactions. This type of medium is depended upon the type of transport enhancement desired. The bifurcating channel pattern provides higher transport efficiency, compared to that of a parallel channel pattern with the same terminal channel dimensions, through (1) a decrease in pumping power and (2) a decreased transport resistance. This p...

Thin-Film Heat Exchanger

techtran@uoregon.edu — Tue, 15 Sep 2009 17:19:19 GMT

As a result of improved construction techniques and materials, residential and commercial buildings are becoming increasingly sealed from the outdoor environment. Because of inadequate ventilation in such buildings, the indoor air can contain a variety of substances that pose a health risk to its occupants. Consequently, there is a trend toward increasing the use of ventilation systems in order to improve indoor air quality. Increased ventilation, however, can significantly increase the heating and cooling loads on a building's heating, ventilation, and air-conditioning (HVAC) system, ...

Formaldehyde Free Adhesives

mary.foley@oregonstate.edu — Thu, 10 Sep 2009 10:45:36 GMT

The invention describes adhesive compositions produced from abundant and renewable resources such as decayed lignocellulosic materials, as well as other inexpensive components such as borates and/or polyethyleneimine. Also, disclosed are lignocellulosic composites that are made from the adhesive compositions. Applications: Any application currently utilizing phenol-formaldehyde or urea-formaldehyde resins, such as wood composite materials. U.S Patent 7,265,169 -02-34

Mold Infections Diagnosis

mary.foley@oregonstate.edu — Thu, 10 Sep 2009 10:45:36 GMT

In the past two years, a new disease Jejunal Hemorrhage or Dead gut Syndrome has appeared in dairies across the United States. Often this disease affects only adults and cows are dead within 24 hours. A precise method has not been developed and symptoms of gastrointestinal disorders in ruminants overlap. This new invention will allow rapid diagnosis of the fungal infections. It is a new method discovered by OSU researcher Neil Forsberg and Steve Puntenney for diagnosing jejunal hemorrhage, or Dead Gut, syndrome in animals by amplifying a fungal nucleic acid sequence of Aspe...

Chromatic Control In Sulfide Phosphor (Sulfide Phosphor)

mary.foley@oregonstate.edu — Thu, 10 Sep 2009 10:45:32 GMT

This invention describes electroluminescent phosphor compositions, a crystal engineering method that allows chromatic control of phosphor emission across the visible spectrum, and luminescent devices produced from such phosphor compositions. Applications: Flat panel displays, high-definition televisions, CRT's, lasers, and lighting. U.S. Patent: 6,419,855 -98-04

Material with Very Low or Negative Thermal Expansion

mary.foley@oregonstate.edu — Thu, 10 Sep 2009 10:45:30 GMT

The invention concerns materials having low or negative thermal expansion properties. Compounds of interest include tungstates or molybdates, compositions containing such materials, and methods for making the materials and compounds. Applications: Possible uses for compositions of the present invention include circuit boards, optical substrates, low-temperature thermocouples, dental restoratives, catalyst supports, ceramics, and cookware. U.S. Patent : 5,919,720 -96-03

Control of Post Harvest Fungal Disease Using Saprophytic Yeast

mary.foley@oregonstate.edu — Thu, 10 Sep 2009 10:45:29 GMT

In pears and apples losses due to postharvest disease has been estimated to be approximately 9-10 million dollars per year in the United States. Much of the pre- and postharvest loss is due to fungal diseases, such as molds and rots, therefore there is an urgent need for reducing these losses in the United States. The present invention provides compositions and methods for biological control of fungal diseases of agricultural commodities such as pome fruits. The invention provides yeast compositions for biological control of a fungal disease of an agricultural commodity comprising...

Method and Apparatus for Spectrophotometiric Observation of Plants

mary.foley@oregonstate.edu — Tue, 11 Aug 2009 11:29:16 GMT

This invention describes an instrument for making both fluorometric and spectrophotometric images of plants. The instrument includes two sources of electromagnetic radiation, optical components to direct the radiation, excitation and emission filters, and an imaging device. Applications: The instrument can be used to produce high-resolution spectrophotometric images of living plants by correcting for water path length. Advantages: This instrument will allow for large number of plants be screened rapidly by fluorometry while use of the slower spectrophotometric analysis can be used o...

Control of Erwinia Amylovora with Vinylglycines and Organisms that Produce Vinylglycines (GAF Fire Blight)

mary.foley@oregonstate.edu — Thu, 06 Aug 2009 13:23:35 GMT

Fire Blight is a destructive necrotic plant disease that affects a wide range of hosts in the rose family and is a significant problem in pear and apple orchards. The inventors have demonstrated that the growth of Erwina Amylovora, which causes fire blight disease, is inhibited by organic compounds known as vinylglycines. These compounds include the Germination-Arrest Factor (GAF), described in previous OSU invention 08-07, which has been identified by OSU inventors as a specific active compound, FVG. FVG and the bacteria that produce FVG can be used as agents for inhibiting of the gro...

Control of Grassy Weeds with Vinylglycines and Vinylglycine-Producing Organisms

mary.foley@oregonstate.edu — Thu, 06 Aug 2009 13:23:34 GMT

Grassy weeds are a significant problem in a number of agricultural and non-agricultural settings, and the selective control of these weeds presents particular challenges. Oregon State University inventors have identified and structurally characterized a naturally occurring herbicide that promises to be an effective agent for the control of grassy weeds. This novel compound, Germination-Arrest Factor (GAF), is a member of the class of compounds known as vinylglycines and is produced by certain strains of bacteria. This compound irreversibly arrests germination of the seeds of a ...

Bioherbicide

mary.foley@oregonstate.edu — Thu, 06 Aug 2009 13:23:29 GMT

In recent years there has been a steady increase in grassy weed seed contamination in Oregon. This invention is related to biocontrol of weeds, particularly grassy weeds in grass seed cropping systems. The invention utilizes specific Pseudomonas fluorescens strains, specific genes and a specific bioherbicide molecule (Germination-Arrest Factor, GAF) whose biosynthesis is controlled by those genes, to control weeds. GAF and GAF-producing bacteria have the potential of providing a new and specific method for the control of grassy weeds in grass-seed production fields, thereby reducing s...

Resonately Coupled Alpha-Stirling Cooler

mary.foley@oregonstate.edu — Wed, 29 Jul 2009 16:49:59 GMT

Disclosed is a resonantly coupled alpha-Stirling cooler that has hot and cold variable-volume chambers, a regenerator, and a driver for maintaining reciprocating gas displacement between the chambers. Only the hot side of the cooler is driven; the cold side responds passively by resonant coupling. The phase difference between volume oscillations in the hot and cold variable-volume chambers are altered by adjusting the driving frequency. Applications: Disclosed is a simple refrigeration device that can be made small enough to cool electronic components or provide mobile, te...

Microassembly Methods for Miniature Energy and Chemical Systems

mary.foley@oregonstate.edu — Thu, 23 Jul 2009 14:10:51 GMT

Current MEMS fabrication technology cannot accomplish geometries necessary for MECS in a low –cost, high-volume manner. This invention introduces economical microassembly methods which are necessary to allow low- cost, high-volume production of MECS sufficient to compete with conventional macroscale energy and chemical systems. The new method is providing plural laminates at least some of which include structures and substructures that define components of devices, registering the laminates, bonding the laminates and dissociating the components to make the device. U.S. Patent Pub...

Process for Removing Chemical Preservatives From Wood Using Supercritical Fluid

mary.foley@oregonstate.edu — Thu, 23 Jul 2009 14:10:50 GMT

While preserving utility wood polls with chemical treatment significantly prolongs the service life of these and other treated products, these materials are increasingly becoming a subject of concern at the end of their life cycles. The Environmental Protection Agency currently regulates disposal of treated wood using a Toxicity Characteristic Leaching Profile, TCLP, in which materials for disposal are subjected to a leaching procedure. Most wood is treated with pentachlorophenol and majority of wood that needs to be disposed will fail under TCLP requirement. This invention proposed a...

Student Foreign Language Entrepreneurship

iia@pdx.edu — Thu, 23 Jul 2009 11:24:49 GMT

Fischer works with students enrolled in courses to enable them to learn business vocabulary and skills, all in a foreign language. This culminates in the release of products. Originally working only with German, Fischer and other faculty are now exploring how the course can be expanded to other languages.

Guilty Except For Insanity

iia@pdx.edu — Thu, 23 Jul 2009 11:24:49 GMT

Guilty Except for Insanity: Maddening journeys through an American Asylum is a documentary film directed by psychology professor Jan Haaken. The film follows the journeys of individuals over a period of a year who enter the Oregon State Hospital under the "guilty except for insanity" plea. Site of the filming of One Flew Over the Cuckoo's Nest, based on the novel by Ken Kesey, the Oregon State Hospital has been the focus of intense controversy, including charges by the U.S. Department of Justice of massive civil rights abuses of patients. This documentary tells a different side of the sto...

Best Practices for Data Analysis of Longitudinal Studies on Aging: A Practical Guide

iia@pdx.edu — Thu, 23 Jul 2009 11:24:48 GMT

As experts in the area, Newsom and colleagues are creating a new handbook on longitudinal studies on aging, designed for publication through a commercial publisher.

An Efficient Region-of-Interest Cropping Algorithm to Extract Small Regions of Video Out of Compressed Video Streams

iia@pdx.edu — Thu, 23 Jul 2009 11:24:48 GMT

PSU researchers have created a technology which supports fast and efficient region-of-interest cropping from high-resolution video. We have a mechanism to compress a compliant video stream, and still allow cropping.

Modulating Activity of Calcium Release Channels

iia@pdx.edu — Thu, 23 Jul 2009 11:24:47 GMT

Using a new assay for drug development (see Abrj-01), PSU researchers have developed new compounds that may prove useful in the treatment of heart arrhythmia. Ventricular arrhythmias appear to be caused by a calcium leak from the sarcoplasmic reticulum in cardiac muscle, and arrhythmias often lead to heart failure. Drugs that prevent and treat arrhythmias often work by inhibiting this calcium leak. The PSU researchers have shown that their new compounds are a potent inhibitor of calcium leak in skeletal muscle, and will soon be testing the compounds in cardiac muscle a...

Lecture and Q&A with Jane Jacobs

iia@pdx.edu — Thu, 23 Jul 2009 11:24:47 GMT

Video footage of a 2004 interview with Jane Jacobs, an American-born Canadian urbanist, writer and activist best known for The Death and Life of Great American Cities (1961), a powerful critique of the urban renewal policies of the 1950s in the United States.

Method and Apparatus for Sample Analysis

iia@pdx.edu — Thu, 23 Jul 2009 11:24:46 GMT

PSU researchers have developed a novel way to collect, concentrate and analyze gas samples for analysis, primarily in environmental applications. By increasing pressure and performing analyses on a focused gas sample, this technology easily and cheaply enables continuous and real-time monitoring of air quality. Emission sources are more easily identified. An additional application is in metabolic studies or disease diagnosis.

Student Atlas of Oregon

iia@pdx.edu — Mon, 20 Jul 2009 16:52:09 GMT

Bulman and collaborators have developed a printed atlas of Oregon designed for students. Providing these printed atlases to users very inexpensively, they hope to improve students’ knowledge of Oregon geography. They also provide associated workshops around the State.

Method of Using and Producing Tropoelastin and Tropoelastic Biomaterials

iia@pdx.edu — Mon, 20 Jul 2009 16:52:08 GMT

PSU researchers, in collaboration with the Oregon Biomedical Engineering Institute, have developed a new biomaterial that can be used to coat biomedical implants. The technology is currently licensed and under development.

Fluorophore-Tagged Cisplatin

iia@pdx.edu — Mon, 20 Jul 2009 16:52:07 GMT

Many types of cancer, including carcinomas, lymphomas, sarcomas, and others, are treated with the chemotherapy agent Cisplatin. Based on the element platinum, cisplatin causes apoptosis in cancer cells by cross-linking their DNA. Like many chemotherapy agents, Cisplatin's effectiveness could be improved by better understanding how the body moves it around internally, so that it can be better targeted to cancer cells and thus protect normal cells from its effect. PSU researchers invented a fluorescently tagged cisplatin molecule that has been shown by collaborators at Oregon ...

Solution-Based Synthesis of Functional Graphene

iia@pdx.edu — Mon, 20 Jul 2009 16:52:07 GMT

PSU researchers have developed techniques to covalently attach single and multiple layers of graphene sheets on substrates. The graphene can subsequently be functionalized for use in nanobiosensor applications. Procedures are being developed for the solution-based synthesis and functionalization of graphene sheets from graphite in a way that is straightforward, and chemically adaptable. A wide range of range of graphene derivatives can be prepared, promising new materials for graphene based nano-composties, nano-biosensors, and nano-bioeletronics.

Nitrogen Dioxide Gas Sensor

iia@pdx.edu — Mon, 20 Jul 2009 16:52:06 GMT

PSU researchers have developed a new chemical gas sensor capable of detecting nitrogen dioxide (NO2) at levels less than 100ppb (two orders of magnitude more sensitive than current chemiluminescent based NOx sensors), having a dynamic linear range of parts per million to parts per billion, and a speed of detection of 60-120 seconds. Unlike existing chemical gas sensors, the PSU technology uses a special nanocomposite that undergoes selective linear changes in electrical resistance/conductance in the presence of NO2 in a near instant response. Prototypes of the sensor are under de...

Mono-Layer and Multi-Layer Nanowire Networks

iia@pdx.edu — Mon, 20 Jul 2009 16:52:06 GMT

The fabrication of nanoscale materials (by both bottom-up and top-down routes) has been driven by miniaturization of devices and the limitations of Si COMS technology. Research using one-dimensional nano-wires and nanotubes to fabricate nanodevices has demonstrated their potential applications, including field effect transistors, nano-biosensors, solar cells, and nano-generators; however, by and large these devices have been fabricated using a single nano-wire or an array of nano-wires assembled in a complicated, multi-step process. The mass-production of nano-structured devices re...

Nanoporous Membrane Protein Biomarker Detectors

iia@pdx.edu — Mon, 20 Jul 2009 16:52:04 GMT

Disease assessment can be based on one or many biomarkers – a specific gene, protein, or other biological substance – that can be used to assess disease progress and aid in determining treatment. Unfortunately, biomarker-based measurements are often slow, expensive or otherwise impractical. PSU researchers have fabricated biomarker detectors with nano-pores. A nanoporous membrane of biomarker detectors can be sensitized to respond to a single target compound for increased accuracy, or different portions of the nano-membrane can be differently sensitized, allowing for more efficient dete...

Microelectrode Recording Analysis and Visualization for Improved Target Location

iia@pdx.edu — Mon, 20 Jul 2009 16:52:03 GMT

This is a neurosurgery tool to record and analyze microelectrode readings, resulting in more accurate targeting. In addition, these microelectrode visualization methods can be used in other fields of medicine where microelectrodes are used to determine neurological structures, such as deep brain stimulation for alleviating chronic pain, or seizure control.

Synthesis of Nanoscale Structures in Defined Locations

iia@pdx.edu — Mon, 20 Jul 2009 16:52:03 GMT

Since their discovery in 1991 by microscopist Sumio Iijima, carbon nanotubes have intrigued researchers with their structures and the applications enabled by their unique physical properties. Nanotubes exhibit high chemical resistance and mechanical strength, among other desirable physical properties. However, one ongoing challenge to exploiting these desirable properties is the difficulty associated with isolating and manipulating nanotubes for use as discrete device elements. PSU researchers have developed methods for directly synthesizing nanoscale structures in defined l...

System and Method for Simulating Product Design and Development

iia@pdx.edu — Mon, 20 Jul 2009 16:52:02 GMT

This invention consists of methods and software tools that can be used to help companies when bidding new projects, when designing the process they will use for a given project, when managing projects or contractors, when tracking, and when re-planning their projects. In addition, this tool can be used to help companies build a business case and make rational choices among process alternatives and process improvement opportunities.

Quinoline Derivatives and Uses Thereof

iia@pdx.edu — Mon, 20 Jul 2009 16:52:02 GMT

David Peyton has developed hybrid drugs to overcome drug resistances in Malaria, Cancer, and Tuberculosis.

Biosensors Through Impedance Spectroscopy

iia@pdx.edu — Mon, 20 Jul 2009 16:52:02 GMT

Biosensors are analytical devices that combine biologically sensitive elements with optical, chemical, or mechanical transducers for selectively and quantitatively detecting biomolecules. PSU researchers have developed a novel biosensor technology, utilizing nano-particles, that can simultaneously detect and quantify both antigens and antibodies within body fluids with sensitivities and specificities equivalent to or better than existing assays. Due to the advantages of working on the same scale as the measured analytes, the new technology is faster, cheaper, and can be miniaturiz...

Nanocrystal Strucutre Identification

iia@pdx.edu — Mon, 20 Jul 2009 16:52:01 GMT

This project involves methods for identifying crystal structures through analysis of their x-ray diffraction patterns. The current incarnation of the intellectual property on which this proposal will improve is currently available to the research community through a website at PSU. It’s utility to the community has been demonstrated by high website access numbers (21,000 from January to December 08).

Scanning Probe Microscope Calibration

iia@pdx.edu — Mon, 20 Jul 2009 16:52:01 GMT

This project involves methods for calibrating scanning probe microscopes by evaluating the two dimensional symmetry of images taken of two dimensional periodic calibration standards. Initial work on this innovation has resulted in proof of concept, and a PSU patent on this method is being filed currently. The prototype of this project is a tool that would allow users of scanning probe microscopes to add an additional level of confidence to their images.

PVP Potato [Umatilla Russet]

mary.foley@oregonstate.edu — Fri, 17 Jul 2009 14:42:20 GMT

Umatilla Russet potato is available under non-exclusive license from Oregon State University. A license is required to grow any stage (PN/N - G5 or higher) of this variety. Please contact the Licensing Associate for program details. -99-05

Online Sexual Harassment Prevention Training

mary.foley@oregonstate.edu — Thu, 16 Jul 2009 16:12:17 GMT

The goal of this online course is to enable to identify sexual harassment behaviors, respond appropriately if they occur and prevent such behaviors in the future. Using a series of video vignettes, this course illustrates situations that might arise in specific environment and asks set of questions that are designed to present an understanding of sexual harassment. With this knowledge, one can help make an employer that is free of sexual harassment. -07-65

PVP Wheat [Weatherford]

mary.foley@oregonstate.edu — Thu, 16 Jul 2009 16:12:11 GMT

Weatherford is a soft white winter wheat released by Oregon State University. This variety is resistant to stripe rust and foot rot, susceptible to take-all, and moderately resistant to cephalosporium stripe. In addition, it has good milling quality and average baking characteristics. Wheatherford wheat is available as an open release. -98-06

PVP Wheat [Connie]

mary.foley@oregonstate.edu — Thu, 16 Jul 2009 16:12:11 GMT

Connie's yields are similar to those of soft white winter wheat. Connie is especially adapted to growing conditions in the Pendleton and Umatilla areas, which means Pendleton Flour Mills will be able to buy the wheat from local growers.Connie wheat is available as an open release. Additional Inforamtion (publications, web sites) http://oregonstate.edu/dept/ncs/newsarch/1998/Jul98/durum.htm http://cropandsoil.oregonstate.edu/wheat/reports/owc0101.pdf -98-05

Recombinant Cystalin to Improve Fish Processing

mary.foley@oregonstate.edu — Thu, 16 Jul 2009 16:12:09 GMT

A cloned cDNA encoding the cysteine proteinase inhibitor cystatin has been isolated from trout. Via an appropriate expression vector, the trout cDNA was introduced into host cells, such as yeast, to produce large quantities of recombinant cystatin. Also included is a method for the purification of the recombinant cystatin. The encoded cystatin protein is useful to inhibit cysteine proteinases in food processing, for example in the production of surimi (an elastic gel from fish muscle used in imitation crab, scallops and shrimp). Applications: Surimi con...

Current-Steering CMOS Logic Family

mary.foley@oregonstate.edu — Thu, 16 Jul 2009 16:12:05 GMT

In integrated circuitry having both analog and digital circuits fabricated on the same substrate, switching transients produced by the digital circuitry can propagate through the substrate and induce deleterious effects in the associated analog circuitry. Applications: Such switching transients are greatly minimized by the disclosed family of CMOS logic circuits in which a constant DC bias current is steered to change logic states. U.S. Patent 5,162,674 -91-06

Brushless Doubly-Fed Motor Control System

mary.foley@oregonstate.edu — Thu, 16 Jul 2009 16:12:05 GMT

This invention is a control system, which generally will control the operation of AC variable speed drive systems, which use a brushless doubly-fed electric motor in either an induction or a synchronous mode. The invention is a system that takes a polyphase alternating current (AC) power from a grid and uses it to drive various mechanical loads over the entire speed range of the motor. This system has the advantage of reducing the rating of the converter to a fraction of the motor's rating, reducing maintenance and more efficiently operating the hydro-generation of electricity. ...

Methods for Detecting Bioactive Compounds

mary.foley@oregonstate.edu — Fri, 10 Jul 2009 08:59:55 GMT

The invention pertains to a device and methods of using fish chromatophores together with inimate support and measurement components to detect bioactive compounds, and machines for practicing such methods. The bioactive compounds of the invention detect the presence of an impurity, and can sense its presence without identifying it. Applications: The invention can replace or substantially reduce the use of animal testing of products in industries such as food, cosmetics, drugs by color change of a fish chromatophore. U.S. Patent: 6,913,877 -98-32

The use of liquid tin as a catalyst to convert glycerides to esters

mary.foley@oregonstate.edu — Thu, 02 Jul 2009 09:43:24 GMT

Oregon State University has developed a continuous novel approach for the production of biodiesel. The use of Molten Tin or Molten Tin Alloys has been shown to provide excellent catalytic activity in the transesterification of triglycerides in combination with saturated alcohols to form Biodiesel. · Advantages: · &nbs...

Wheat, Soft White Winter, ORH010920 [Goetze]

mary.foley@oregonstate.edu — Thu, 02 Jul 2009 09:26:47 GMT

Goetze is a wheat variety developed at Oregon State University in cooperation with the USDA. Agricultural Research Service (USDA-ARS). It is an awned, short-statured, semidwarf variety with moderately earlymaturity and high yield potential. Goetzeis resistant to stripe rust and moderately resistant to Septoria leaf blotch. Goetze is a soft white winter wheat available as an open release (no license required). For more information, please visit OSU extension web site http://extension.oregonstate.edu/news/story.php?S_No=472&storyType=news -07-47

A Coated, Platform-Generating Tablet

mary.foley@oregonstate.edu — Wed, 01 Jul 2009 16:34:45 GMT

This invention teaches a method where controlled release tablet formulation which is relatively easy and inexpensive to produce using standard equipment, and which can easily be modified by the formulator to program drug release as desired. This invention describes tablets containing expending hydrophilic polymer gums in a matrix tablet which has been polymer film coated over the entire surface and which unexpectedly controls drug release better than as described in previous patents. The invention allows for automatic production of the system, which is greatly simplified because ...

Biosynthetic Gene Cluster of the anticancer antibiotic pactamycin and its potential use

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 15:27:57 GMT

About 70 percent of the bacteria that cause infections in hospitals are now resistant to at least one of the drugs most commonly used for treatment. For example, some organisms are resistant to all approved antibiotics and can only be treated with experimental and potentially toxic drugs. Therefore, to stay ahead of the development of antibacterial drug resistances, there is a pressing necessity to identify new antibiotics, especially those with novel mechanisms of action, and methods of producing such antibiotics. This disclosure describes the molecular cloning of the pactamycin bi...

Cytokinin Enzyme

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 11:16:30 GMT

Isolated nucleic acids encoding zeatin O-glucosyltransferase are disclosed. These nucleic acid molecules are useful, among other things, to produce transgenic plants having modified zeatin O-glucosyltransferase activity. Applications: Used to alter plant traits including seed development and yield. U.S. issued Patent: 6,600,091 B1. -98-08

Pollutants Degrading Fungai-Air Biofilter

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 11:16:29 GMT

This invention utilizes the filamentous fungus Graphium sp., which is one of the few organisms known to grow on gaseous n-alkanes including; ethane, propane and n-butane. The fungus, while growing on n-alkanes, can cometabolically oxidize and degrade the gasoline oxygenate, methyl tert-butyl ether (MTBE). Methods for bioremediation of MTBE-contaminated media and bioremediation systems which incorporate these organisms are included. Applications: MTBE is used as a gasoline oxygenate to reduce emissions of carbon monoxide from automobile exhaust. Current consumption of this compound in ...

Detection of Clavibacter Michiganensis Subsp. Sepedonicus

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 11:16:29 GMT

This invention utilizes DNA fragments which have been cloned and sequenced that are specific to the pathogen, Clavibacter Michiganensis ssp. Sepedonicus, that causes bacterial ring rot of potatoes. Presently, detection of this pathogen in seed potatoes relies on immunofluoresence procedures, gram staining, and a bioassay on an alternate host eggplant. The eggplant bioassay is protracted and costly, necessitating large growth room facilities to screen the numerous samples. Applications: Laboratories testing for pathogens in plants would use this inven...

Compound Exhibiting Antioprolferative Activity Against Cells

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 11:16:28 GMT

This invention relates to chemical compounds, isolated and purified from a marine blue-green algea (cyanobacterium), exhibiting biological activity. Certain natural environments continue to be fruitful sources of chemical compounds having unusual and unexpected properties, including possible medicinal properties. It has been found that Lyngbya majuscula yields several isomers of a cytotoxic compound. One isomer, termed "Curacin A" exhibit substantial activity particularly against proliferating cells. U.S. Patent 5,324,739 -93-09

Natural Browning Inhibitors and Antioxidants from Pineapple (Antioxidants)

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 10:23:43 GMT

Food processors are seeking alternatives to bisulfate which can serve as inhibitors of enzymatic browning in “fresh cut” and processed fruits and vegetables. There is a segment of the population that is hyper-sensitive to bisulfate and most processors would prefer to avoid use of sulfite if they could find alternatives.OSU inventors established that pineapple juice is inhibiting browning in fresh and dried apple rings and they identified three compounds in pineapple which are glutathipne derivatives of sinapyl alcohol, S-sinapyl-L-cysteine, N-L-.gamma.-glutamyl-S-sinapyl-L-cystei...

Dual Quantization Oversampling Digital-To-Analog Converter

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 09:57:27 GMT

An oversampling D/A converter system achieves high linearity and low quantization error by using dual internal D/A converters: one with high linearity but high quantization error and the other with low linearity but low quantization error. A signal path in the system includes an L-bit quantizer for quantizing a digital input signal into an L-bit signal plus a quantization error and a D/A converter for converting the L-bit signal and quantization error into an analog signal. A correction path that parallels the signal path includes an M-bit quantizer, where M is greater &nbs...

Biopolymer Thickener

mary.foley@oregonstate.edu — Tue, 30 Jun 2009 09:48:27 GMT

Lactic acid bacteria are capable of producing many types of exopolysaccharides, some of which play important roles as thickeners and stabilizers in food products. This invention includes a natural isolate of Lactococcus lactis ssp. cremoris that produces a smooth body and excellent texture in low fat or no fat dairy products. This bacterial strain is GRAS (Generally Regarded As Safe) which can be added to foods. Applications: Microbial polysaccharides have diverse applications. Foods, chemicals, pharmaceuticals and waste treatment and oil recovery facilities all exploit va...

Novel Continuous Flow Microchemical Systems for the Deposition of Functional Thin Films

mary.foley@oregonstate.edu — Thu, 25 Jun 2009 10:21:27 GMT

This invention uses microreaction technology to control reacting flux (temperature, species distribution, nanoparticle size and their distribution) before imprinting on the substrate for deposition. Advantages: · This novel microchemical system presents a new tool to tailor thin film micro-and nanostructures. · The novel continuous flow microchemical systems are ideal not only to implement chemical bath deposition but also other soft solution processing techniques. · &nb...

A Simple and General Route to Digital Fabrication of Inorganic Electonic Materials

mary.foley@oregonstate.edu — Thu, 25 Jun 2009 10:20:07 GMT

OSU inventors, Dr.Chih-hung Chang, Doo Hyoung Lee and Yu-Jen Chang have developed simple and general routs to form high performance inorganic electronic materials( semiconductors, insulators, conductors and luminescent materials) that are suitable for digital fabrication. This newly invented routs could be implemented through a variety of processing techniques including digital fabrication techniques such as inkjet printing, gravure, micro-pen, nano fountain- pen or blanket coating techniques like screen printing, spray coating, slide coating, slot coating, curtain coating and spin ...

The Pacific Northwest Anti-Inflammatory Reference Cookbook (CD)

dincherk@ohsu.edu — Wed, 24 Jun 2009 16:10:37 GMT

Please note that your are ordering the CD version of the cookbook. This version will be delivered via US Mail to the address provided with your order. Are you curious about the Anti-Inflammatory diet and ready for a change in your eating habits? This cookbook is for you: If you want to try an anti-inflammatory diet but you don't know where to start. If you love to cook and look for new ways to create nutritious, satisfying meals. ...

The Pacific Northwest Anti-Inflammatory Reference Cookbook

dincherk@ohsu.edu — Wed, 24 Jun 2009 16:10:36 GMT

Please note that your are ordering the PDF version of the cookbook. This version will be delivered electronically to the email address you provided with your order. Are you curious about the Anti-Inflammatory diet and ready for a change in your eating habits? This cookbook is for you: If you want to try an anti-inflammatory diet but you don't know where to start. If you love to cook and look for new ways to create nutritious, satisfying meals. &nbs...

Accessory panel for diagnostic platform, patient bed and other support surfaces.

dincherk@ohsu.edu — Wed, 24 Jun 2009 16:02:35 GMT

Technology OverviewDesigned by nurses, this is an apparatus to hold drainage systems, bags, and other appliances, while a patient is moved in and out of a CAT scanner, MRI, x-ray or other medical testing machines. The device is an accessory to a table and provides areas to hang bags without interferring with the scans. Currently, no commercially available table accessories exist to keep drainage systems safe and without creating back flow of fluids into the patient while being scanned.

Safe Moves DVD for Patient Transportation

dincherk@ohsu.edu — Wed, 24 Jun 2009 16:02:26 GMT

Technology OverviewDeveloped by patient transportation experts at Oregon Health & Science University, this DVD provides training in the procedures to be used for transporting patients and safety issues for both the providers and patients. View the demo at: http://media.ohsu.edu/ramgen/adm/edcomm/safemovesdemo.rm

Full Text To Speech with OGIResLPC

dincherk@ohsu.edu — Wed, 24 Jun 2009 16:02:23 GMT

Technology Overview This is a signal processing sub-system for the Festival open-source text-to-speech system. The task of the sub-system is to concatenate acoustic units, modify pitch and timing of the speech signal after concatenation. The sub-system is based on residual-excited linear prediction. Recordings are analyzed via linear prediction, the reflection coefficients and residuals are stored, and, during pitch and timing modification, overlap-add algorithms are applied to the residuals signal. This system produces higher quality speech than systems in which the excitation...

Droplet Desorption

mary.foley@oregonstate.edu — Mon, 22 Jun 2009 16:55:07 GMT

Problem : Heat-actuated cooling minimizes the need for electricity by using waste heat, such as car-engine exhaust. Economic success of this concept depends on development of more compact, lighter-weight components. Invention: One important component is the desorber, to separate two fluids in an absorption-cycle heat-actuated cooling scheme. The droplet concept significantly reduces the size and weight of the desorber. This invention leads to the technical feasibility of a new generation of heat-actuated cooling devices using one-hundredth of the electric power r...

Prevention of Crown Gall by Co-Suppression of Agrobacterium

mary.foley@oregonstate.edu — Mon, 22 Jun 2009 16:55:02 GMT

The bacterial genus Agrobacterium contains several species that cause tumorous growths (galls) in economically important plants, such as apple trees and grape vines. Without adequate control, gall disease remains a multimillion-dollar worldwide problem. OSU inventors discovered that DNA molecules, when introduced into plants, can produce transgenic plants having enhanced resistance to tumors caused by Agrobacterium pathogens. The invention also encompasses transgenic plants that contain these nucleic acid molecules. Additional Information (publications, web sites, and patent l...

Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin

mary.foley@oregonstate.edu — Thu, 18 Jun 2009 15:43:19 GMT

This technology describes the molecular cloning of the enduracidin biosynthetic gene cluster from Streptomyces fungicidicus, the characterization of the individual genes in the gene cluster and the proteins encoded thereby. In addition, enduracidin analogs are described which are produced by mutant Streptomyces organisms. For example, tetrahydorenduracidin A, tetrahydroenduracidin B, deschloroenduracidin A and deschloroenduracidin B are described. Methods for producing such organisms are also described. To stay ahead of the development of antibacterial drug resistances,...

Hydrazide-Functionalized Isotope-Coded Affinity Tag (HICAT)

mary.foley@oregonstate.edu — Thu, 18 Jun 2009 14:48:48 GMT

Current techniques for detecting lipid- generated aldehydes have the important disadvantage that they are not quantitative. This invention however provides a new analytical method that is capable of identifying, characterizing, and quantifying oxylipids-conjugated proteins in complex peptide mixtures. The invention provides a new group of reagents, Hydrazide-Functionalized Isotope-Coded Affinity Tag (HICAT), which include a biotin affinity moiety, a linker with either carbon-12 or carbon-13 and aldehyde-reactive moiety (either hydrazide or hydroxylamine). These two groups react with al...

Induction of apoptosis in cancer cells

mary.foley@oregonstate.edu — Thu, 18 Jun 2009 14:20:30 GMT

The present invention provides compounds that are useful inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. This invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells. U.S. Patent: 7,053,071 -02-35

Novel Enteric Coated Compositionsthat Release Therapeutics in Gastric Fluid

mary.foley@oregonstate.edu — Thu, 18 Jun 2009 10:23:52 GMT

The invention is directed to a pharmaceutical composition for site specific delivery of drugs to the stomach or to small intestine. This pharmaceutical composition consists of enteric material composition that delivers drug into gastric fluid and into intestinal fluid. The specific enteric material composition allows gastric fluid to penetrate into the composition of the drug and drug to be released from the composition while still being in the stomach. This unique composition will allow the drug to be released in the stomach and part of the drug remaining in the composition is rapidl...

Continuous Process for the Production of Biodiesel using Tin Catalyst

mary.foley@oregonstate.edu — Wed, 17 Jun 2009 16:59:19 GMT

Oregon State University has developed ground-breaking continuous catalytic techniques for the production of biodiesel. These tin-based catalysts have demonstrated excellent activity in the transesterification of triglycerides in combination with saturated alcohols to form biodiesel. Biodiesel production of the present invention eliminates many of the difficulties of traditional high temperature or supercritical non-catalytic methods and substantially reduces the disadvantages of traditional heterogeneous catalytic methods of transesterification. Advantages: 1.&nb...

Compounds for Pest Control and Methods for Their Use

mary.foley@oregonstate.edu — Wed, 17 Jun 2009 11:23:22 GMT

The control of public health pests is critical for numerous vector-borne diseases over much of the world. Pest control is often difficult to achieve and there is a need for an effective pesticide capable of controlling a variety of pests, therefore, the development of safe and effective repellents and toxicants that contain natural products perceived by the public as environmentally friendly and safe are of significant public health importance in the fight against vector-borne diseases. This new compound, which represents an unidentified class of naturally-derived pesticides, will ...

Isolation and Structure Elucidation of the Antiproliferative Peptide Coibamide A

mary.foley@oregonstate.edu — Tue, 16 Jun 2009 15:23:41 GMT

This technology is related to cancer treatment. Chemotherapy has become a focus in cancer treatment, however natural products are the ultimate source of more than fifty percent of the clinical trials for the treatment of caner. The present invention relates to isolation, structure, and purification, of the novel antiproliferative cyclic peptide compound Coibamide A, that was isolated and purified from a Panamanian marine cyanobacterium and it has ability to act as a chemotherapeutic agent. US Patent pending -06-52

Methods of Producing Validienamycin Analogs and Uses

mary.foley@oregonstate.edu — Tue, 16 Jun 2009 15:11:18 GMT

The antifungal agent validamycin A is a commercially important compound due to its wide application in controlling fungal infection of rice plants caused by Rhizoctonia solani. This invention is a method of producing validamycin A analogs and biosynthesis and their potential use. The invention further relates to the use of validamycin biosynthetic gene valN knock-out mutant strains to produce validamycin analogs which could be used as drugs and drug precursors for uses in humans, animals and plants as antifungal agents. Additional Information (publications, web sites and panten...

Zebrafish Assay to Identify Chemical Modulators of Tissue Regeneration

mary.foley@oregonstate.edu — Tue, 16 Jun 2009 14:37:56 GMT

There are currently no vertebrate models that can be used to rapidly screen for small molecules that modulate fin regeneration. This approach has the potential to revolutionize the field of regeneration medicine and provides an opportunity to identify the targets of identified bioactivities. The present invention provides a rapid throughput zebrafish regeneration assay, which may be used to identify pathways essential for tissue regeneration. Most vertebrates are incapable of tissue regeneration; however zebrafish have the remarkable capability to regenerate their fins, optic ne...

Insight Resume

mary.foley@oregonstate.edu — Tue, 16 Jun 2009 11:09:27 GMT

The purpose of Insight Resume (IR) is to promote student success through more accurate assessment of student preparedness and academic potential. In addition to it's potential for making more accurate admissions decisions, this non-cognitive, holistic assessment provides OSU with more information on applicants, earlier than we've ever had before. With this instrument developed by OSU, and the information it provides, we are able to proactively connect students to services that will help them be successful when they marticulate to OSU. Additional Information (publications, we...

Securement System for a Rollable Mobility Aid

mary.foley@oregonstate.edu — Tue, 16 Jun 2009 10:49:34 GMT

This invention describes a broad securement system for a rollable mobility aid that can be located in a surrounding structure such as the interior of a vehicle. U.S. Issued Patent: 5,344,265 92-05

PVP Clearfield Soft White Winter Wheat [ORCF-103]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:30 GMT

ORCF-103 is a soft white winter wheat available for license on a semi-exclusive basis. Please contact the Licensing Associate for more information and an application packet. -08-46

PVP Wheat [Tubbs 06]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:29 GMT

A reselection of the variety Tubbs with reduced susceptibility to current races of stripe rust. Agronomically similar to Tubbs, with broad adaptation to wheat production areas of the Pacific Northwest. Open release to seed companies and growers. -07-49

Wheat, Hard Red Winter [Norwest 553]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:29 GMT

Norwest 553 is a hard red winter wheat available for license on a semi-exclusive basis. Please contact the Licensing Associate for more information and an application packet. -07-48

PVP Potato [Modoc]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:27 GMT

Modoc is available for license through the Potato Variety Management Institute, Inc. Please visit http://www.pvmi.org for license details. -05-02

PVP Potato [Willamette]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:26 GMT

Willamette is available for license through the Potato Variety Management Institute, Inc. Please visit www.pvmi.org for license details. -05-01

PVP Wheat [Tubbs]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:26 GMT

Tubbs is a soft white winter wheat variety available as an open release (no license required). -03-25

PVP Wheat [ORCF-101 Clearfield]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:25 GMT

OSU release in cooperation with BASF Corporation. ORCF-101 is a soft white winter wheat variety amd possesses Clearfield™ herbicide resistance technology to facilitate control of grassy weeds. High yield potential, broadly adapted, with superior resistance to Strawbreaker footrot, Cepahlosporium stripe, and Fusarium Crown rot as compared with currently available Clearfield™ varieties. Available for license on a semi-exclusive basis from Oregon State University. Please contact the licensing associate for more information and an application packet. ...

PVP Potato [Wallowa Russet]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:25 GMT

Produces much higher yield of U.S. No. 1s than Russet Burbank Excellent frozen processing characteristics Adapts to a wide range of soil and climatic conditions Wallowa Russet is available for license through the Potato Variety Mangement Insitute. Please go to http://www.pvmi.org for more information about license details. -01-27

PVP Wheat [Winsome]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:24 GMT

Winsome is a hard white spring cultivar available as an open release (no license required.) -01-04

PVP Potato [Winema]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:24 GMT

Excellent appearance with a bright red skin, shallow eyes and few defects Produces a high percentage of marketable tubers Susceptible to most fungal diseases and corky ringspot Winema potatoes are available for license through the Potato Variety Management Institute, Inc. (PVMI). Please go to www.pvmi.org for license details. -00-17

PVP Potato [Mazama]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:23 GMT

Bright red-skinned potatoes suitable for table use and the red-skinned creamer market Produces a higher percentage of marketable tubers than Red LaSoda or Dark Red Norland More resistant to potato virus Y than Dark Red Norland and much more resistant than Red LaSoda Mazama is available for license through the Potato Variety Management Institute, Inc. (PVMI). Please go to http://pvmi.org for license details . -00-16

PVP Potato [Klamath Russet]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 10:49:23 GMT

Consistently produces higher total yields and much higher yields of U.S. No. 1s with larger tuber size than Russet Burbank or Russet Norkotah Higher in sugars than and similar in vitamin C and protein to Russet Burbank Very resistant to common scab, moderately resistant to verticilium wilt, very susceptible to potato leafroll virus Klamath Russet is available for license through the Potato Management Variety Institue, Inc. (PVMI). Please go to http://www.pvmi.org for more information about license details. -00-15

PVP-Soft White Winter Wheat [ORCF-102]

mary.foley@oregonstate.edu — Mon, 15 Jun 2009 08:30:44 GMT

ORCF-102 is a soft white winter wheat variety available for license on a semi-exclusive basis. Please contact the licensing associate for more information and an application packet -05-16

CTIP2 Diagnostic Marker and Drug Screening Tool for Head and Neck Cancer

mary.foley@oregonstate.edu — Fri, 12 Jun 2009 15:44:24 GMT

Head and neck squamous cell cancers are the sixth most common cancers in the world, the researchers said in their study, and a significant cause of mortality. In 2008, cancers of the oral cavity and pharynx alone accounted for 35,310 new cases in the United States and 7,590 deaths. Despite the development of new types of treatments for head and neck cancer, the mortality rates have not improved much in the last 20 years. Drs. Mark Leid, Arup Indra, Gitali Indra and Joseph Abecassis have invented a method to determine the expression of the transcriptional regulator CTI...

LYSB Borate Nonlinear Optical Crystals

mary.foley@oregonstate.edu — Thu, 11 Jun 2009 14:14:13 GMT

Nonlinear optical (NLO) crystals are commonly used in laser technology for the conversion of light from one frequency to another. Among known NLO crystals, borates of the type LiB3O5 (LBO) and BaB2O4 (BBO) have found wide commercial success because of their capabilities for generating high-power laser light. These and other NLO compounds are, however, limited in their application to the generation of UV and VUV light as they are damaged by exposure to high power lasers, exhibit excessive absorption and light scattering of incident or absorbed light, may be hydroscopic, and...

Ornamental Hazelnut- Red Dragon- Corylus avellana

mary.foley@oregonstate.edu — Thu, 11 Jun 2009 13:45:47 GMT

The 'Red Dragon' cultivar (a red-leafed, contorted ornamental cultivar) is available by license from Oregon State University. Please contact the Licensing Associate for more information about the licensing program. -08-09

Energy Scavenging MECS Expander/Compressor

mary.foley@oregonstate.edu — Fri, 05 Jun 2009 15:50:04 GMT

Researchers at OSU, Drs. Richard Peterson, Kevin Drost and Thomas Herron have developed a microtechnology-based heat actuated heat pumps for man portable cooling, vehicle cooling and distributed space conditioning. The key to portable applications of cooling is the development of a compact heat actuated heat pump that does not require electric power or shaft work. This eliminates the need for a portable power source needed by a vapor-compression cycle. Power sources (either batteries or power generators) tend to be heavy relative to the simple combustion equipment using in a heat actu...

Organic and Biological Chemistry of Nitrated Lipids

techtran@uoregon.edu — Fri, 05 Jun 2009 12:03:00 GMT

Living organisms are continually challenged by highly reactive oxygen species (ROS) and reactive nitrogen species (RNS). In many cases ROS and RNS are destructive, but in some cases their chemistry has been channeled into biologically useful purposes. Nitrated lipids are produced by the action of ROS/RNS on lipids--such lipids have recently been demonstrated to be a new source of the signaling molecule nitric oxide and to be potent signaling molecules themselves. Bioorganic approaches to studying nitrated lipids include examining the synthesis of nitra...

Simultaneous Beta and Gamma Spectroscopy

mary.foley@oregonstate.edu — Thu, 04 Jun 2009 14:03:51 GMT

Oregon State University is seeking a company interested in the manufacture and commercialization of a state-of-the-art radiation detection system for real-time and simultaneous spectroscopy of beta-particles and gamma-rays. The spectrometer has proven to be an effective tool for recording separate beta gamma-ray spectra from mixed radiation fields. Applications: Nuclear non-proliferation Surgical probes Environmental assessment Hot-particle dosimetry Radioactive waste management Simultaneous gross beta & gross gamma counting Dose assessment & risk analysis Advantages: This tec...

Non-Magnetic High Energy Density Left-Handed Waveguides

mary.foley@oregonstate.edu — Thu, 04 Jun 2009 13:02:06 GMT

This invention describes a new type of composite negative refractive index material that can bend light the “wrong way” providing a wide range of optical and electronic applications. The material is made up of reflective and transparent Further development of the material is needed but it is anticipated that it can be used to shrink infrared optical systems and create a super lens to see objects the size of a nanometer — about one-100,000th of a human hair’s diameter. It could also improve electronic manufacturing, data storage and medical systems. T...

A Mouse Model for the study of Congenital Myopathies

mary.foley@oregonstate.edu — Thu, 04 Jun 2009 12:46:16 GMT

A new mouse model for the study of muscular dystrophy, has been developed by Drs. Kioussi and Gross. The Pitx2 LoxP mouse model will allow researchers to further study the mechanisms underlying development of the disease, as well as test potential new therapies. -08-22

CORI (Clinical Outcomes Research Initiative) Endoscopy Procedure Software

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:31 GMT

NOTE: This is a site license for the CORI Software with 5 user login accounts. To obtain more login accounts (licensed in groups of 5), visit the Extra Login Page at: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425628 To obtain 20 hours of customer service and software updates for 1 year, visit the Annual Subscription Page at: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=425634 To obtain additional software interfaces for CORI Software, visit the following links:CORI-ADT interface using HL7http://www.ohsu.e...

Patient Transport Device

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:30 GMT

Technology Overview In light of the August 2007 decision by the Centers for Medicare and Medicaid Services to discontinue payments to hospitals for healthcare acquired pressure ulcers, emergency room nurses at OSHU responded by devising a Patient Transport Device Patients arriving in hospital emergency rooms frequently are placed on hard surfaces for extended periods of time which is condusive to skin irritation and pressure ulcers. To decrease skin irritation, control moisture and ultimately reduce pressure ulcers, the Patient Transport Device is constructed ...

AudioTest Software

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:29 GMT

Technology Overview AudioTest is a custom, desktop software application developed in visual C#/C++ for development of custom sound loalization and questionnaire tests in audiology research. It can be used for testing of sound localization, hearing, otoacoustic emissions, and other psychometric evaluation of research subjects. The software allows researchers to create basic tests. Users can include calibrated audio stimuli which may be presented to the research subjects during a test sequence. All testing results are stored to a Microsoft Access databse and may be easily exporte...

CORPORA from CSLU: Yes/No v1.2

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:29 GMT

The Yes/No Corpus v1.2 is a collection of answers to yes/no questions from other CSLU corpora The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place your order: 1. Click on the type of license you wish to order: Academic or non-profit entity or Commercial entity. 2. Terms of the license agreement can be viewed by clicking on the word "terms...

CORPORA from CSLU: Voices v1.0

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:28 GMT

The VOICES Corpus contains 12 speakers reading 50 phonetically rich sentences. The recording procedure involved a "mimicking" approach which resulted in a high degree of natural time-alignment between different speakers. The acoustic wave and the concurrent laryngograph signal were recorded for 1 "free" and 2 "mimicked" renditions of each sentence. Pitch marks, calculated from the laryngograph signal, and time marks, the output of a forced-alignment algorithm, have been added to the corpus. NOTE: This corpus is available for non-commercial use only. Developing a successfu...

CORPORA from CSLU: The Spoltech Brazilian Portuguese v1.0

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:28 GMT

The Spoltech Brazilian Portuguese corpus v1.0 contains microphone speech from a variety of regions in Brazil with phonetic and orthographic transcriptions. The utterances consist of both read speech (for phonetic coverage) and responses to questions (for spontaneous speech). The corpus contains 480 speakers and 8119 separate utterances. A total of 2579 utterances have been transcribed at the word level (without time alignments), and 5505 utterances have been transcribed at the phoneme level (with time alignments). Protocol design, recording and transcription were performed by the Univ...

CORPORA from CSLU: Stories v1.2

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:28 GMT

The Stories Corpus v1.2 is made up of extemporaneous speech collected from English speakers in the CSLU Multi-language Telephone Speech data collection. Each speaker was asked to speak on a topic of their choice for one minute. These utterances make up the Stories Corpus The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place your order: 1. Clic...

CORPORA from CSLU: SR4X v1.2

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:27 GMT

This corpus is a collection of 36 speakers saying eleven words six times on four different channels. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place your order: 1. Click on the type of license you wish to order: Academic or non-profit entity or Commercial entity. 2. Terms of the license agreement can be viewed by clicking on the word "...

CORPORA from CSLU: Spelled and spoken words v1.2

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:27 GMT

The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place your order: 1. Click on the type of license you wish to order: Academic or non-profit entity or Commercial entity. 2. Terms of the license agreement can be viewed by clicking on the word "terms". 3. You agree to the terms of the license agreement when you click on "Add to Order" and pro...

CORPORA from CSLU: Speaker recognition v1.1

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:27 GMT

The Speaker Recognition corpus v1.1 (formerly known as Speaker Verification), consists of telephone speech from 91 participants. Each participant has recorded speech in twelve sessions over a two-year period answering questions like "what is your eye color" or respond to prompts like "describe a typical day in your life." Most of the utterances in the release of the corpus have corresponding non-time-aligned word level transcriptions. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial e...

CORPORA from CSLU: Numbers v1.3

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:27 GMT

The Numbers Corpus v1.3 is a collection of naturally produced numbers. The utterances were taken from other CSLU telephone speech data collections, and include isolated digit strings, continuous digit strings, and ordinal/cardinal numbers. A total of 23902 files are included in this corpus. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To pla...

CORPORA from CSLU: National cellular v2.3

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:26 GMT

The Cellular Corpus v2.3 consists of cellular telephone speech from 2336 callers from locations throughout the United States. The data collection contains requests for fixed vocabulary and continuous speech utterances. A total of about one minute of speech from each caller is collected. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place y...

CORPORA from CSLU: Names v1.3.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:26 GMT

The Names Corpus v1.3 is a collection of 24,245 first and last name utterances from 20184 speakers. The utterances were taken from many other telephone speech data collections that have been completed at the CSLU, during which callers were asked to say their first and last names, or asked to leave their name and address to receive an award coupon (addresses are not include in corpus). Each file in the Names corpus has an orthographic transcription following the CSLU Labeling Guide. Also, to take advantage of the phonemic variability, 24245 of the utterance have been phonetically trans...

CORPORA from CSLU: Multilanguage telephone speech v1.2.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:26 GMT

The Multi-language Telephone Speech Corpus consists of telephone speech from 11 languages: English, Farsi, French, German, Hindi, Japanese, Korean, Mandarin, Spanish, Tamil, Vietnamese. The corpus contains fixed vocabulary utterances (e.g. days of the week) as well as fluent continuous speech. The current release includes recorded utterances from about 2052 speakers, for a total of about 38.5 hours of speech. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora f...

CORPORA from CSLU: Multichannel overlapping numbers

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:25 GMT

A portion of the Numbers corpus played through loudspeakers, re-recorded on a 12-channel table-top microphone array in a meeting room. NOTE: This corpus is currently not available for commercial use. The Center for Spoken Language Understanding (CSLU) distributes corpora academic institutions for a fee. To place your order: 1. Click on the type of license you wish to order: Academic or non-profit entity or Commercial entity. 2. Terms of the license agreement can be viewed by clicking on the word "terms". 3. You agree to the terms of the license agreement wh...

CORPORA from CSLU: Kids speech v1.1

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:25 GMT

The Kids' Speech Corpus v1.1 was developed to facilitate research about the characteristics of kids' speech at different ages and to train and evaluate recognizers for use in language training and other interactive tasks involving children. For instance, this corpus was used to train recognizers used in language development with deaf children. Speech was gathered from children in grades K through 10. Approximately 100 children at each grade level have been recorded. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic instit...

CORPORA from CSLU: Isolet.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:25 GMT

ISOLET v1.3 is a database of letters of the English alphabet spoken in isolation. The database consists of 7800 spoken letters, two productions of each letter by 150 speakers. It contains approximately 1.25 hours of speech. The recordings were done under quiet, laboratory conditions with a noise-canceling microphone. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models ...

CORPORA from CSLU: Foreign accented English.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:24 GMT

The Foreign Accented English (FAE) corpus consists of American English utterances by non-native speakers. The corpus contains 4925 telephone quality utterances from native speakers of 23 languages. Three independent judgments of accent were made on each utterance by native American English speakers. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. T...

CORPORA from CSLU: Cellular words and phrases.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:24 GMT

The Cellular Words and Phrases Corpus consists of utterances gathered from callers who were using cellular telephones. Each caller listened and responded to a series of pre-recorded prompts from a fixed protocol. There are 346 callers represented in this corpus. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place your order: 1. Click on the...

CORPORA from CSLU: Apple words and phrases.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:24 GMT

The Apple Words and Phrases corpus was developed with support from Apple Computer, Inc., who also supplied the list of words and phrases to be collected. This telephone speech corpus contains about 69.5 hours of speech. 998 calls were collected on an analog system and 2010 calls were collected on a digital system. Each caller repeated a list of phrases as they were prompted. The phrases were command and control type phrases, e.g. "help". The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entit...

CORPORA from CSLU: Alphadigit.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:23 GMT

The Alphadigit Corpus is a collection of 78,044 examples from 3,025 speakers saying six digit strings of letters and digits over the telephone. A total of about 82 hours of speech are included in Release 1.3. Each file has an orthographic transcription and time align transcription as well. The Center for Spoken Language Understanding (CSLU) distributes corpora to commercial entities and academic institutions for a fee. Commercial entities can use these corpora for research but also for creating commercial products such as generating acoustic models for speech recognition. To place ...

CORPORA from CSLU: 22 Language.

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:23 GMT

The 22 Language corpus consists of telephone speech from 22 languages: Eastern Arabic, Cantonese, Czech, Farsi, German, Hindi, Hungarian, Japanese, Korean, Malay, Mandarin, Italian, Polish, Portuguese, Russian, Spanish, Swedish, Swahili, Tamil, Vietnamese, and English. Unfortunately French is not available. The corpus contains fixed vocabulary utterances (e.g. days of the week) as well as fluent continuous speech. We were expecting at least 300 callers in each language. Each utterance is verified by a native speaker to determine if the caller followed instructions when answering ...

Sperm Quality Assay & ICSI Improvements

dincherk@ohsu.edu — Wed, 03 Jun 2009 17:48:22 GMT

Diagnostic Assay This diagnostic technology provides for a simple and direct means of determining sperm quality in humans and in commercially important animal breeding stocks. Ubiquitination is an important signal for rapid degradation of intracellular proteins so marked by the ubiquitin peptide. The inventor, Dr. Peter Sutovsky, noted that ubiquitin antigens appear on the exterior surface of some spermatozoa, and that the proportion of ubiquitin labeled sperm in a sample correlated inversely with the ability of the semen to accomplish fertilization. Thus, in addition to such factors ...

Screen for Redox Activity of Compounds

iia@pdx.edu — Wed, 03 Jun 2009 14:09:21 GMT

The design of new and effective drugs is a multi-billion dollar business, requiring great expense and extensive testing of drug candidate compounds. Obtaining a better understanding of the pharmacodynamics and mechanisms of action of drug candidates is an important and necessary step in optimizing any lead compound. A property of increasing importance to some drugs' mechanism of action is their redox activity; in particular, a common factor in drugs aimed at affecting membrane bound transport proteins appears to be their ability to redox couple to th...

Shear-Force Ultrasonic Near-Field Microscope

iia@pdx.edu — Wed, 03 Jun 2009 14:09:20 GMT

The Shear-Force Ultrasonic Near-Field Microscope (SUNM) is a nanometrology tool for surface and subsurface materials characterization, including the dynamic behavior of fluid-like mesoscopic films confined between two sliding solid boundaries. By mechanically exciting the film and detecting the resulting sound emitted, the elastic properties of the absorbed film itself (which can be altered by the sample's surface properties) and the mechanical response of the surrounding surface (which can be altered by the presence of subsurface defects) can be inferred. As a surface metrology tool, the SUN...

Development of Boron-Nitrogen Heterocycles

techtran@uoregon.edu — Wed, 03 Jun 2009 08:29:41 GMT

The Liu research group is developing a number of B–N-containing heterocycles, namely 1,2-dihydro-1,2-azaborines. These are structures that are isoelectronic and isostructural to benzene. Benzene, the epitome of aromatic compounds, has played a pivotal role in our fundamental understanding of the concept of aromaticity. The aim is to exploit the unique properties of 1,2-dihydro-1,2-azaborines and investigate their potential as benzene surrogates in materials and biomedical research. Areas of exploration include organic synthesis, optoelectronic materials...

Heterometallic Group 13 Keggin-like Nanoclusters

techtran@uoregon.edu — Wed, 03 Jun 2009 08:29:39 GMT

The Johnson research group has developed a high-yielding synthetic strategy for preparing discrete polynuclear inorganic clusters containing thirteen Group 13 metals (Al, Ga, In) in a Keggin-like structure. Seven of the metal ions comprise the interior core, arranged in a flat hexagonal disc and bridged by hydroxo ligands. The remaining six metal ions are each bound to the core by two mu-OH bridges. Examples of higher nuclearity metal cation clusters of any morphology with mixed metal components are fairly rare, and control of the metal stoichi...

Green Fluorescent Protein Indicating Redox Potential

techtran@uoregon.edu — Fri, 29 May 2009 11:17:38 GMT

Changes in the redox equilibrium of cells influence a host of cell functions. Redox-sensitive green fluorescent proteins (GFP) allow real time visualization of the oxidation state of a cell. Go to the Office of Technology Transfer

Substituted Tetrakis (Arylethynyl) Benzenes

techtran@uoregon.edu — Fri, 29 May 2009 11:06:00 GMT

Organic compounds possessing a high degree of conjugation are recognized as ideal materials for advanced electronic and photonic applications including organic LEDs, LCDs, thin film transistors, solar cells, and optical storage devices. Optical and physical properties of highly conjugated organic molecules can be altered by changing the substitutional groups and substitution patterns. Functionalized phenylacetylene and phenylvinylene structures are known to exhibit remarkable optical and electronic properties because of their multiple conjugated pathways. ...

Polymer Light Emitting Devices Based On Interfaces Enabled By Internally Compensated Doped Conjugated Polymers

techtran@uoregon.edu — Thu, 28 May 2009 17:41:04 GMT

There is a need for low cost, stable and efficient light-emitting devices for solid-state lighting. Polymer light-emitting electrochemical cells (PLECs) are being actively explored for their potential in this area. The stability and efficiency of current PLECs needs to be improved if they are going to be practical. In order to improve stability and efficiency, one must be able to independently control electron and hole injection and such control cannot be achieved with current technologies. Research in the Lonergan lab has shown that independent control over carrier i...

Strongly Asymmetric Broadband Mirrors

techtran@uoregon.edu — Thu, 28 May 2009 17:41:03 GMT

This invention provides dispersion-engineered thin films for coating asymmetric mirrors. This allows for the custom design of optical asymmetry, including the design of broadband, non-dispersive asymmetry which is not possible with standard thin metal films. U.S. Patent Application No. 11/983,335 Go to the Office of Technology Transfer

New Dyes for Forensic Applications

iia@pdx.edu — Wed, 27 May 2009 18:16:56 GMT

Fingerprints are the most common and useful physical evidence for the apprehension and conviction of crime perpetrators. Reagents for the detection and enhancement of fingerprints are among the most useful tools in this regard. However, the available fluorogenic reagents for detecting and enhancing fingerprints left in blood have several associated challenges. For instance, some are generally unsuitable for dark and multi-colored substrates, while those that are (luminol, fluorescin) are not compatible with fixatives and their oxidation products or are not insoluble, lea...

Tunable Phenylacetylene Scaffolds for Ion Binding updated with additional data

techtran@uoregon.edu — Wed, 27 May 2009 16:16:44 GMT

This technology encompasses a series of organic compounds for use in rapid detection of ions and small molecules. These compounds have a previously unknown framework that is modular and pre-organized to bind guests in its cavity. The modular nature of the framework permits easy synthetic variation of the compound structure and several of the regions can be varied to incorporate a specific property, such as solubility, optimization of guest binding, or fluorescence. The core of the organic framework is a highly-conjugated rigid backbone that makes the...

Zinc Oxide Nanowires

techtran@uoregon.edu — Wed, 27 May 2009 16:16:44 GMT

This technology is a method for the selective growth of ZnO vertical nanowire arrays, as developed by UO inventors. It offers several advantages over other ZnO nanowire production methods: selective placement of the wires, rapid growth, no need for vacuum, and minimal generation of Au waste. Go to the Office of Technology Transfer

Simplified Drawing/Graphing and Text Submission Tool

techtran@uoregon.edu — Wed, 27 May 2009 16:16:43 GMT

This web-based tool allows users to create and submit computer-generated diagrams and technical drawings simply and effortlessly, with particular application for online homework and testing. It has been successfully used with Economics classes at the University of Oregon The tool is designed to be simple and intuitive: users would not need any previous skill with graphics software. "Shape Tool Boxes" contain the visual building blocks of the diagrams to be created (different tool boxes can be created for different applications) and the resulting diagram ...

Low Thermal Conductivity Misfit Layer Compounds

techtran@uoregon.edu — Wed, 27 May 2009 16:16:43 GMT

Misfit layer compounds are constructed of two interwoven repeating layers, resulting in materials which exhibit extremely low thermal conductivity. Potential applications include use as small-scale thermoelectric or insulating materials. Go to the Office of Technology Transfer

Turbostratically Disordered Thermoelectric Materials

techtran@uoregon.edu — Wed, 27 May 2009 16:16:42 GMT

Turbostratically disordered inorganic materials which exhibit surprisingly low thermal conductivity and have potential to be used as thermoelectric materials. U.S. Patent Application No. 12/090,849. Go to the Office of Technology Transfer

Multi-Layered Based Seed Methodology for Self-Aligned Silicides

techtran@uoregon.edu — Wed, 27 May 2009 16:16:41 GMT

An improved process for producing silicide deposits on silicon-based semiconductor chips, with a reduction in the number of lithography steps and phases required. Go to the Office of Technology Transfer

Method for Preparing Superlattices

techtran@uoregon.edu — Wed, 27 May 2009 16:16:40 GMT

A method for preparing inorganic materials with a superlattice structure allows for thermoelectric materials to be synthesized in larger quantities than currently available. U.S. Patent Application No. 10/522,346. Go to the Office of Technology Transfer

Variable Barrier Diode/Sensor

techtran@uoregon.edu — Wed, 27 May 2009 16:16:39 GMT

This device is a Schottky-type diode with a continuously variable barrier height (variable over 0.5V) and nominally a three terminal variable barrier diode. The technology can be either permanently or reversibly switched, with potential application in multiple-state information storage. It may also be used in the fabrication of standard two terminal diodes. Here, the technology provides a means of fabricating diodes with precisely controlled effective barrier heights that are tunable over approximately a 0.5V range. U.S. Patent No. 6,455,873 &n...

Mutant Fluorescent Proteins

techtran@uoregon.edu — Wed, 27 May 2009 16:16:39 GMT

Functional engineered fluorescent proteins with varied fluorescence characteristics that can be easily distinguished from currently existing green and blue fluorescent proteins. Such engineered fluorescent proteins enable the simultaneous measurement of two or more processes within cells and can be used as fluorescence energy donors or acceptors when used to monitor protein-protein interactions through FRET. Longer-wavelength engineered fluorescent proteins are particularly useful for photodynamic toxicity, and auto-fluorescence of cells are significan...

Making Amorphous and Crystalline Alloys by Solid State Interdiffusion

techtran@uoregon.edu — Wed, 27 May 2009 16:16:39 GMT

This method is a new synthetic approach in which thin (15-50 A) amorphous elemental layers are sequentially deposited to create a unique initial reactant. The approach overcomes the limitations of traditional, diffusion-limited, solid-state synthetic methods, which offer no control of the reaction pathway and therefore no control over which intermediates are formed. In the new synthetic approach, the initial layered composite is diffused at low temperatures to produce a homogeneous amorphous alloy; nucleation is then the rate-limiting step in the f...

Complexation-Mediated Crystal-Forming Reactions Using Complexing Agents

techtran@uoregon.edu — Wed, 27 May 2009 16:16:38 GMT

This technology comprises methods and reaction systems that are adapted for forming crystallites with novel crystal habits and/or morphologies when compared to conventional crystallites of the same chemical composition. The methods and reaction systems involve chemical reactions between at least two reactant compounds occurring in a liquid (or gel) that form insoluble crystallite products. At least one of the reactants is rendered soluble, in a solvent in which the reactant is not normally soluble, by adding an agent and the reactant. The complexing a...

Balance Evaluation Systems Test: BESTest

dincherk@ohsu.edu — Wed, 27 May 2009 12:41:40 GMT

Technology OverviewCurrent clinical balance assessment tools do not determine the underlying constraints on a balance disorder. The BESTest is a new clinical balance assessment tool that is unique in allowing clinicians to determine the type of balance problems in patients. The BESTest combines both original tasks and tasks/items taken from the literature to create a systematic, theoretical framework for identifying the underlying constraints of a balance disorder. Rather than just assuming that ï¿½balanceï¿½ is one system, the BESTest breaks down control of balance into six distinct p...

Use of Tyrphostins to Stimulate Neurite Outgrowth

dincherk@ohsu.edu — Wed, 27 May 2009 12:35:28 GMT

Technology OverviewThe use of tyrphostin A9 and its pharmaceutically acceptable derivatives as neurotrophin-like agents are able to protect against neurotoxins and to accelerate nerve regeneration, and thus can treat neurodegenerative diseases and nerve injuries in the central and peripheral nervous systems, including (but not limited to) Parkinson's disease (PD), multiple sclerosis (MS), spinal cord injuries and peripheral neuropathies. Tyrphostin A9 has been found to stimulate neurite outgrowth in the presence of nerve growth factor in SK-SY-5Y cells, a human neuroblastoma ce...

Nematode Research Tools

techtran@uoregon.edu — Tue, 26 May 2009 13:13:58 GMT

These novel nematode research tools facilitate simultaneous studies on the behavior and activity of individual nematodes (C. elegans). The tools can be used alone or in combination for C. elegans studies. They include: · Microfluidic devices with channels that are specifically designed to mimic the worm's motion in soil · An integrated gradient generator for use with the microfluidic devices · An electropharyngeog...

Oregon Career Information System (ORCIS)

techtran@uoregon.edu — Tue, 26 May 2009 13:13:57 GMT

The Career Information System is available to provide career-related advice and evaluation for all Oregonians. For more information, please visit the ORCIS website. Go to the Office of Technology Transfer

Ambient Pressure NO2 Sensor

iia@pdx.edu — Tue, 26 May 2009 12:37:05 GMT

The measurement of nitrogen dioxide (NO2) is important to both environmental monitoring and to research of flame, combustion, and surface chemistry. Current methods and devices operate at very low, sub-ambient pressures, requiring a substantial pumping system and limiting their usefulness in applications in higher pressure environments where direct and non-intrusive measurement of NO2 are desirable. PSU researchers have developed a selective and sensitive fluorescence based method and instrument for the direct measurement of NO2 at ambient pressure. The current prototype has...

Learner Web

iia@pdx.edu — Tue, 26 May 2009 12:37:04 GMT

The Learner Web is a learning support system providing structure and resources for adults who want to accomplish specific learning objectives. A learner can access the system through the Internet. In addition to on-line resources, the Learner Web integrates support services from existing local education programs, community based organizations, tutors, and telephone helpers. The Learner Web consists of a Web-based software system that is implemented regionally. The System is organized around Learning Plans. A Learning Plan is a set of steps structured around achieving an identified goal. For e...

Transparent Proof-of-Work Mechanism for Protecting Web Applications from Attack

iia@pdx.edu — Tue, 26 May 2009 12:37:04 GMT

PSU researchers have developed a transparent, backwards compatible proof-of-work system -- a defense mechanism that allows server owners to give client-specific challenges to those requesting access to network resources. All clients are provided tasks to perform prior to access being granted, with easier & harder tasks available depending on the maliciousness of the client and the demand load on the server.

Cleaner, Less Expensive Amine Production

iia@pdx.edu — Tue, 26 May 2009 12:37:01 GMT

PSU researchers and their collaborators have uncovered and engineered a new class of enzymes - the nitrile oxido reductases - that can aid in the chemical production of amines. In today's society, chemical manufacturing industries are facing increasing demands to practice environmentally conscientious methods and processes. Like all businesses, they also have a constant need to increase efficiency in their processes to maximize their bottom line. These two factors, among others, are driving a rapid increase in the use of enzymes in important industrial chemical transformatio...

Carbon Nanotube Multiplexers

iia@pdx.edu — Tue, 26 May 2009 12:37:00 GMT

Miniaturization of electronic and mechanical devices has permitted complex and sophisticated products to be realized inexpensively in compact packages. Such miniaturization has developed based primarily on advances in silicon wafer processing for circuit fabrication or micro-electromechanical systems. Unfortunately, at this point in time the incremental improvement of silicon wafer processing cannot lead to further significant enhancements in miniaturization. New nano-scale technologies that greatly reduce the size of circuits, actuators, and multiplexers will bring about th...

High Frequency Active Inductor

iia@pdx.edu — Tue, 26 May 2009 12:37:00 GMT

An integrated inductor capable of operating at gigahertz (1 billion Hz) frequencies and above is a critical element in oscillators, filters, and wide-band low-noise amplifiers, (LNAs). The main applications are radio-frequency (RF) communication and high-speed data processing integrated circuits, such as those in cellular phones, wireless network cards, and broadband transceivers. Active integrated inductors are an alternative to passive inductors when the need for maximum selectivity (Q) prohibits the use of a passive inductor or when die area is limited. The key innovations of t...

EyeDraw Software: An Interactive System For Drawing Pictures With The Eyes

techtran@uoregon.edu — Tue, 26 May 2009 12:29:09 GMT

EyeDraw is a novel research project under development at the University of Oregon that enables users to draw pictures solely with the use of their eyes. The application interprets eye movement data collected by an eye tracking tool, allowing users to click on buttons, choose starting and ending points, and save and retrieve drawings. EyeDraw is being designed for children and teenagers with severe mobility impairments. More information can be found on the project website at http://www.cs.uoregon.edu/research/cm-hci/EyeDraw/ Go to the Office of Tech...

Rendezvous

techtran@uoregon.edu — Fri, 22 May 2009 16:17:32 GMT

The Rendezvous database aids states in complying with the State Performance Plan (SPP) requirement of the 2004 Individuals with Disabilities Education Act (IDEA). The SPP is a strategic framework to aid states in improving certain areas of special education and services to student with disabilities. Data is collected from school districts and each year the state submits an Annual Performance Report (APR) to the U.S. Department of Education. The SPP's overall objective is to improve outcomes for students with disabilities and enhance accounta...

Use of Pentamidine in Myotonic Dystrophy Models

techtran@uoregon.edu — Fri, 22 May 2009 16:17:31 GMT

Myotonic Dystrophy is characterized by 200–2000 CUG repeats in the 3’UTR of the DMPK gene—unaffected individuals have 5–35 CUG repeats. The CUG repeats form a stem-loop and it’s been suggested that this is a gain-of-function mutation wherein the stem loop binds proteins in the cell so that the proteins are unavailable to perform their normal cellular functions. Muscle-blind splicing factor is one such sequestered protein. As a result, at least 23 pre-mRNAs have been identified as mis-spliced and at least 15 proteins have defects. One hypothesis for guidin...

Strong Kids Curriculum

techtran@uoregon.edu — Fri, 22 May 2009 16:17:29 GMT

The Strong Kids programs are a set of curricula that teach social and emotional skills, promote resilience, strengthen assets, and increase coping skills of children and adolescents. The programs are developmentally appropriate and span the K-12 age range: Strong Start (grades K-2), Strong Kids (grades 3-8, including versions for both elementary and middle school students), and Strong Teens (grades 9-12). Several studies have shown the programs to be effective in increasing knowledge of social-emotional concepts and coping skills, as well as decreasing problem sy...

Synthesis of Cerium Containing Thermoelectric Candidate Materials

techtran@uoregon.edu — Fri, 22 May 2009 16:17:29 GMT

New thermoelectric materials have been made that are cerium-containing. U.S. Patent Application No. 11/357,738. Go to the Office of Technology Transfer

TAU Performance System

techtran@uoregon.edu — Fri, 22 May 2009 16:17:28 GMT

TAU Performance System® is a portable profiling and tracing toolkit for performance analysis of parallel programs written in Fortran, C, C++, Java and Python. TAU (Tuning and Analysis Utilities) is capable of gathering performance information through instrumentation of functions, methods, basic blocks, and statements. All C++ language features are supported, including templates and namespaces. The API provides selection of profiling groups for organizing and controlling instrumentation. The instrumentation can be inserted in the source code by using an automatic tool b...

ACCESS: Advancing Career Counseling and Educational Support for Survivors of Domestic Violence

techtran@uoregon.edu — Fri, 22 May 2009 16:17:28 GMT

The Advancing Career Counseling and Educational Support for Survivors of domestic violence (ACCESS) curriculum is a group career-counseling curriculum for victims of domestic violence. Initially created as a five-week pilot program by Prof. Krista Chronister of the Counsing Psychology Program at UO's College of Education, the curriculum is available to the public and includes a training manual for facilitators and a workbook for participants. Go to the Office of Technology Transfer

Culture Collection of Microorganisms from Extreme Environments

techtran@uoregon.edu — Fri, 22 May 2009 16:17:27 GMT

The Culture Collection of Microorganisms from Extreme Environments (CCMEE) was created in 1999 by the consolidation of the collections of Dr. E. Imre Friedmann of Florida State University and Dr. Richard Castenholz of the University of Oregon. The newly-formed CCMEE contains cultures from all over the world, including Antarctica, Israel, Asia, Africa, New Zealand and North America. The majority of cultures were collected from extreme environments such as hot and cold deserts, hypersaline waters, hot springs, acidic waters, and habitats exposed to high solar irradiance...

Ultra-Sensitive Optical Sampling by Coherent-Linear Detection

techtran@uoregon.edu — Fri, 22 May 2009 16:17:27 GMT

This new approach to optical waveform measurement is based on linear optical sampling: a short optical pulse provides the gating function and the sampling is accomplished using coherent homodyne mixing on a low speed photodetector, a linear optical process. The phase sensitivity inherent to homodyne detection is removed by simultaneous measurement of orthogonal phase quadratures, and the combination of ultrafast optical gating with linear homodyne detection and low speed optoelectronics enables high temporal resolution with sensitivities over 1000x greater than comparable ...

Correcting Metamorphopsia

techtran@uoregon.edu — Fri, 22 May 2009 16:17:26 GMT

A method and apparatus for the evaluation and measurement of metamorphopsia, a visual disorder in which images appear distorted. This invention provides a very sensitive test for metamorphopsia that detects early retinal changes at a time when therapeutic intervention may be more helpful. The test can be used on a home PC, for greater frequency and ease of use. The apparatus includes a pattern generation tool that can be used to identify areas of scotoma and to record the level of vision distortion in the patient. Subsequent measurements track the changes in...

Thermodynamically Metastable Skutterudite Crystalline-Structured Compounds

techtran@uoregon.edu — Fri, 22 May 2009 16:17:24 GMT

Inventors have discovered a way to prepare numerous skutterudite compounds which cannot be readily prepared using conventional solid state chemistry synthesis. This invention avoids the limitations of conventional synthesis (chiefly high temperatures and slow diffusion rates) by using a multilayer precursor technique which allows the diffusion rate to be controlled. This technique yields research quantities of high-quality samples in a fraction of the time required in conventional methods and therefore is ideal for rapidly preparing a wide variety of compos...

Complete Streets Assessment Tool (CSAT) 1.1

techtran@uoregon.edu — Fri, 22 May 2009 15:37:16 GMT

The Complete Streets Assessment Tool (CSAT) uses mobile GIS mapping technology to evaluate streets and intersections from the perspective of pedestrians, cyclists, and transit users. CSAT is intended for use by non-technical community groups, with a dual emphasis on data collection and community coalition building, but public agencies will find the tool to be useful as well. CSAT includes a graphical user interface (GUI), custom data entry forms, and desktop GIS map templates along with tool documentation, a technician’s manual and digital and printed promo...

Bicycle Assessment Safety Index Tool (BASIT) 1.0

techtran@uoregon.edu — Fri, 22 May 2009 15:37:16 GMT

The Bicycle Assessment Safety Index Tool (BASIT) uses mobile GIS mapping technology to evaluate streets and intersections from the perspective of cyclists for bicycle route planning and evaluation. BASIT is intended for non-technical community groups to use, with a dual emphasis on data collection and community coalition building, but public agencies will also find the tool to be useful. BASIT includes a graphical user interface (GUI), custom data entry forms, and desktop GIS map templates together with tool documentation, a technician’s manual and digital a...

Accessibility Audit Tool (AAT)

techtran@uoregon.edu — Fri, 22 May 2009 15:37:16 GMT

The Accessibility Audit Tool (AAT) uses mobile GIS mapping technology to evaluate intersections from the perspective of compliance with the Americans with Disabilities Act and beyond. AAT is intended for use by non-technical community groups as well as public agencies and departments of transportation. AAT includes as graphical user interface (GUI), custom data entry forms, and desktop GIS map templates together with tool documentation, a technician’s manual, and digital and printed promotional media. AAT was developed by Prof. Marc Schlossberg&nb...

Climate Master Program

techtran@uoregon.edu — Fri, 22 May 2009 15:08:03 GMT

The Climate Master™ program was developed by the University of Oregon Climate Leadership Initiative to increase climate literacy, reduce greenhouse-gas emissions at the household level, and build public support for climate-positive technology and policy. The program consists of a thirty-hour training program in which participants learn to incorporate climate action into their daily life by reducing greenhouse-gas emissions in their home, yard, food, transportation, as well as considering general consumption choices. Individuals pay for the free or low-...

SWIS - School-Wide Information System

techtran@uoregon.edu — Fri, 22 May 2009 15:08:03 GMT

The School-Wide Information System (SWIS) is a web-based information system designed to help school personnel to use office referral data to design school-wide and individual student interventions. The three primary elements of SWIS are: · An efficient system for gathering information · A web-based computer application for data entry and report generation · A practical process for using information for decision making These...

Course Document Management System

techtran@uoregon.edu — Fri, 22 May 2009 12:47:54 GMT

Features of the Course Document Management System online tool include: · Individual syllabi creation for instructors, with pre-defined and customizable fields · Electronic submission of syllabi and other course documents for review · Comparison to specified criteria or standards to determine the alignment of syllabi and other documents with selected criteria or standards · ...

Colorful Lanterns at Shangyuan Interactive CD

techtran@uoregon.edu — Fri, 22 May 2009 12:29:01 GMT

The digitization of the chinese scroll Lantern Festival at Shangyuan makes a unique work of art accessible for a wide audience, and is ideal for both individual and classroom study. The interactive CD allows users to study the complete painting in depth: meticulous electronic cleaning of the scanned work has made visible details that are unrecognizable in the original, and a “zoom” option allows for minute examination of any area. A series of ‘hotspots’ invites users to explore points of interest with pop-up windows containing detailed background information...

Understanding US History, Volumes 1 & 2

techtran@uoregon.edu — Fri, 22 May 2009 11:03:43 GMT

Understanding U.S. History is a two-part textbook series that teaches students a general strategy for analyzing historical events, processes, and periods by analyzing the problem-solution-effect. The strategy is then applied to U.S. history using original materials. The program contains concept maps and interspersed questions (to foster higher-order thinking) and a variety of writing projects. The texts are written by Carnine, Crawford, Harniss & Hollenbeck in 1994 and include: Understanding U.S. History, Volume 1 - Through 1914 Understanding U.S. History, Volume 2 - Recons...

Inhibitor to Alleviate cc-Chemokine Driven Inflammatory Disease

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:25 GMT

Technology Overview Treatment of inflammatory disorders represents a large market opportunity that has attracted numerous companies developing agents against a wide range of novel targets. Among these new targets are chemokines, proteins that attract immune system cells to inflammation sites. The chemokine system consists of more than 50 known ligands and approximately two dozen receptors. Most of these receptors belong to one of two major subfamilies based on the arrangement of two of the first four cysteine residues in the protein's molecule-the CXC chemokines and the CC chemokines....

Cytokine Treatment for Septic Shock

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:24 GMT

Technology OverviewSeptic shock is a serious medical condition caused by decreased tissue perfusion and oxygen delivery as a result of infection and sepsis. It can cause multiple organ failure and death. Its most common victims are children, immunocompromised individuals, and the elderly, as their immune systems cannot cope with the infection as well as healthy adults are able. The condition develops as a response to certain microbial molecules which trigger the production and release of pro and anti-inflammatory mediators which act to stimulate an immune response. Strategies aimed ...

Methods for Promoting Nerve Regeneration Using Centella Asiatica Compounds

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:19 GMT

Technology OverviewCentella asiatica extracts promote nerve regeneration. Following traumatic or disease-induced axonal degeneration or transaction in the peripheral nervous system, axonal regeneration and neural network re-connectivity may ensue, often resulting in at least partial functional recovery. However, the new axons extend randomly, and are often misdirected. Recovery is also slow as the rate of axonal elongation is slow. Centella asiatica herb, commonly known as â€œgotu kolaâ€, is an Indian medicinal plant used for over 200 years. Modern u...

Compounds Useful in Nerve Regeneration

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:16 GMT

Technology OverviewThis technology represents a new method for using a known structural class of compounds (bastadin) to promote nerve regeneration and neurite growth following nerve trauma or exposure to progressive neurological diseases like Multiple Sclerosis, Parkinsonâ€™s disease and Huntingtonâ€™s disease. Nerves that are severely damaged by disease or by transection or crushing injuries are unable to broadcast the signal between the neuron cell body and the effector cells. Interruption or blockage of these signals is similar to the cutting of an electrical cord connec...

Allogeneic Stimulation of Macrophages

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:14 GMT

Technology OverviewThis invention provides methods of culturing virus in monocyte-derived macrophages through allogeneic stimulation of peripheral blood mononuclear cells (PBMC) or through culture of PBMC with media comprising IFN-g, stable cultures of such virally permissive monocyte-derived macrophages, and methods of screening for viral inhibitors using such cultures. Importantly, this invention and associated patent rights describes an in vitro system that can be used to study viruses; for example, to identify mechanisms involved in the maintenance of viral latency and to explore ...

Methods and Reagents for Using Mammalian Melanocortin Receptor Agonists and Antagonists to Modulate Feeding Behavior in Animals (MC3&4)

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:13 GMT

Technology OverviewThe present invention provides a biological screening system for identifying and characterizing compounds that are agonists or antagonists of mammalian melanocortin receptors, MC3-R and MC4-R, with the capacity to influence or modify metabolism and behavior in an animal, particularly feeding behavior. It is an advantage of the present invention that it provides an in vitro screening method for characterizing compounds having melanocortin receptor binding activities that relate to feeding behavior in animals. Specifically, the invention advantageously provides...

Mammalian Melanocortin Receptors and Uses (MC3)

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:13 GMT

Technology OverviewThis invention relates to the isolation, cloning and sequencing of a complementary DNA copy of the messenger RNA (mRNA) of a novel rat melanocortin receptor gene responsive to g-melanocyte stimulating hormone, a-melanocyte stimulating hormone and adrenocorticotropic hormone. This receptor has been termed the melanocortin-3 receptor (MC3-R). The invention relates to the construction of eukaryotic recombinant expression constructs capable of expressing MC3-R in cultures of transformed eukaryotic cells, and the production of MC3-R in such cultures. The invention relat...

Mammalian Adrenocorticotropic Hormone Receptors and Uses (MC2)

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:12 GMT

Technology OverviewThe present invention relates to the mammalian adrenocorticotropic hormone receptor (ACTH) which is a type of melanocortin receptor (MC2). The fact that this receptor belongs to the melanocortin receptor family implies close association between several physiological processes including stress homeostatic mechanisms, regulation of food intake, immunity and skin function. This receptor is found in the zona fasciculate of the adrenal cortex and stimulates production of cortisol. The invention is directed toward the isolation, characterization and pharmacolo...

Mammalian Melanocyte Stimulating Hormone Receptors and Uses (MC1)

dincherk@ohsu.edu — Thu, 21 May 2009 14:28:12 GMT

Technology OverviewThe melanocortin 1 receptor (also known as the melanocyte-stimulating hormone receptor or MC1r) is one of the key proteins in regulating hair and skin color. A member of the family of G-protein-coupled receptors, it functions at the surface of pigment producing cells (called melanocytes). The proopiomelanocortin (POMC) gene product is processed to produce a large number of biologically active peptides. Two of these peptides, alpha-melanocyte stimulating hormone (aMSH), and adrenocorticotropic hormone (ACTH) have well understood roles in control of mel...

intoCAREERS

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:43 GMT

intoCAREERS develops information and software that assists people in making informed career choices, and provides support to organizations that use, and add value to, its products. The intoCAREERS software system delivers high-quality national and localized information about occupations, employment, education and training to students and adults. For more information about the program, please visit the intoCAREERS website. Go to the Office of Technology Transfer

Monoclonal Antibodies

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:42 GMT

The University of Oregon's Monoclonal Antibody Facility, in close collaboration with university researchers, developed novel monoclonal antibodies against a variety of proteins and peptides that are used in studies of molecular structure, subcellular activities, and cellular differentiation. Many of these monoclonal antibodies are now available through MitoSciences, Inc. Others, listed below, are available by direct licensing from the University of Oregon or through our non-exclusive licensed distributors. Hu proteins are RNA binding proteins that are expressed very early in...

The Pupillary Dilation Response: A Tool for Assessing Sensory Performance in Humans

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:41 GMT

This tool demonstrates a correlation between the magnitude of a person’s involuntary pupil dilation and their hearing. A subject’s pupil size increases when they hear a sound, and the magnitude of the pupil increase is proportional to the intensity of the sound. The Pupillary Dilation Response tool can use this correlation to test hearing in patients who are unable to respond intentionally (i.e., raise their hand) to a traditional hearing test. Such patients may include those receiving ototoxic anticancer drugs, or children who are too young to spea...

School Environment Assessment Tool (SEAT)

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:37 GMT

The School Environment Assessment Tool (SEAT) helps communities assess the strengths and limitations of the area around a school to determine how consistent it is with walking and biking. Unlike other assessment tools, SEAT is designed with a dual emphasis on data collection and facilitation of community organizing and capacity building. SEAT uses sophisticated geographic information system software, but is easy to use for all skill levels and works on handheld computers. Data collected with SEAT is meant to be shared in a workshop format attended ...

Beautiful Dorena - a Novel Drawing Software Program

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:32 GMT

Beautiful Dorena is an innovative drawing program for children and adults, developed by the creator of the popular Kid Pix drawing program, Prof. Craig Hickman. Beautiful Dorena combines the light-hearted personality of a computer game with the creative and productive possibilities of conventional drawing programs. Along with the standard artistic tools, Beautiful Dorena offers unique options like a wave distortion effect that ranges from "Ripples" to "Breakers", a line-drawing tool that succumbs to gravity, an option to send rubber balls bouncing around the screen, and m...

Early Developmental Assessment of Numeracy (EDAN)

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:24 GMT

Early Developmental Assessment of Numeracy (EDAN) is a novel tool that rapidly assesses a preschool-aged child’s developmental numeracy. Developmental numeracy is a contemporary term used to describe a young child’s emerging skill-set for understanding and employing numerical cognitive processes. These processes can be observed in infants, toddlers, and preschoolers, prior to their ultimate representation as mathematic calculation. This assessment is appropriate for use with preschool children ages 3-6, and is designed to detect incremental changes in the building-blo...

mSSL

techtran@uoregon.edu — Thu, 19 Feb 2009 13:05:13 GMT

mSSL offers protected client-to-client data sharing in addition to other features. Conventionally, a client needs to directly request data from a server. A new trend of data service over the Internet is to allow multiple clients, such as thousands of clients of a web server, to share data among themselves in a peer-to-peer fashion. This mechanism can potentially prevent a server from being overwhelmed when serving large audiences, and enable even an under-provisioned site to provide scalable data service. Accompanying this trend, however, are new security challeng...

Off-Resonant Receive Coil with Integrated Amplifier for Magnetic Resonance Imaging

techtran@uoregon.edu — Thu, 19 Feb 2009 12:31:43 GMT

Researchers at the University of Oregon have developed a new technology for reception and amplification of magnetic resonance images. Signal reception in magnetic resonance imaging relies on radio-frequency receive coils, the design of which is the single most important factor determining image quality. In recent years the use of arrays of receive coils has led to the introduction of powerful parallel imaging techniques. These techniques have made it possible to obtain images in a fraction of the time. Pushing the limits of parallel imaging requires arrays of dozens or even hundreds ...

Dynamic Indicators of Basic Early Literacy Skills (DIBELS) Data System

techtran@uoregon.edu — Thu, 19 Feb 2009 12:31:40 GMT

The Dynamic Indicators of Basic Early Literacy Skills (DIBELS) are a set of standardized, individually administered measures of early literacy development. DIBELS are designed to be short (one minute) and used regularly to monitor the development of pre-reading and early reading skills. The measures were developed upon essential early literacy domains, discussed in reports by the National Reading Panel (2000) and National Research Council (1998), to assess student development of phonological awareness, alphabetical understanding, and automaticity and fluency with ...

The Nolli Map: Visualizing Rome

techtran@uoregon.edu — Thu, 19 Feb 2009 12:31:40 GMT

Giambattista Nolli’s engraved map of Rome, created in 1748, is widely regarded by scholars as one of the most important historical documents of the City ever created. The Nolli Map Project at the University of Oregon is a collaborative exploration of the exquisite engraving, from its historic significance to its contemporary application. Visit the Nolli Map website for more information. Go to the Office of Technology Transfer

Atlas of Oregon CD-ROM

techtran@uoregon.edu — Thu, 19 Feb 2009 12:31:25 GMT

The Atlas of Oregon, developed by the InfoGraphics Lab at the University of Oregon is a detailed and comprehensive guide to the geography, economics and history of the State of Oregon. In its new CD-ROM format, the Atlas of Oregon won two top awards in the international Map Design Competition for 2002, conducted by the American Congress on Surveying and Mapping (ACSM). Like the book, the CD version won the "Best in Show" and "Best of Category" awards (in the Book and Atlas division). Please see the Atlas of Oregon website for more info...

GradWeb

techtran@uoregon.edu — Thu, 19 Feb 2009 12:31:19 GMT

GradWeb is proven, powerful, scalable and fully customizable web-based education software developed at the University of Oregon. GradWeb meets the administrative needs of graduate education by providing a medium for interaction between graduate schools, departments, students, faculty and registrars. Visit the GradWeb website for more information. Gradweb is available through either Eugene Software Solutions or the University of Oregon. Go to the Office of Technology Transfer

EC CARES: Early Childhood Coordinating Agency for Referrals, Evaluation and Services for Lane County

techtran@uoregon.edu — Thu, 19 Feb 2009 12:31:03 GMT

EC CARES provides early intervention and early childhood special education services to infants, toddlers and preschool age children. For more information, please visit the EC Cares website. Go to the Office of Technology Transfer

TNT, A General Purpose Least Square Refinement for Macro-Molecular X-Ray Crystallography

techtran@uoregon.edu — Thu, 19 Feb 2009 12:30:55 GMT

This package is a complete suite of computer programs for optimizing the fit of macromolecular models to x-ray crystallographic data. The parameters of the atomic model can be restrained to structure factors and the principles of stereochemistry. The programs are very general and can be used for any macromolecular problem. A model can be restrained by other forms of data without modification to the code. The programs all operate in a similar fashion, reading free-format input using a common set of keywords. All Fourier transforms are calculated with sp...

Interactive Historical Atlas - Multimedia

techtran@uoregon.edu — Thu, 19 Feb 2009 12:30:54 GMT

The Mapping Project is designed to provide interactive and animated representations of fundamental historical problems as well as illustrations of historical events, developments, and dynamics. The Project is interested in licensing maps to distributors and educators who would like to utilize the interactive maps in their curriculum. Available online at Mapping History. Go to the Office of Technology Transfer