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Compositions for treatment of neurological and oxidative stress disorders
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 6/22/2021   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
Oligonucleotides for Long QT Syndrome
Oligonucleotides to prevent poly(A) adenylation at intron 9 of the KCNH2 gene, and pharmaceutical compositions comprising the oligonucleotides and methods to use same to treat long QT syndrome. Included are antisense sequences to specific sites in intron 9. KCNH2, also known as ether-a-go-go related gene 1 (hERG1) encodes the Kv11.1 channel that conducts...
Published: 1/29/2015   |   Inventor(s): Zhengfeng Zhou, Qiuming Gong, Matthew Stump
Keywords(s): Therapeutics, Therapeutics - General, Therapeutics - Other
Category(s): Therapeutics
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