Search Results - imaging

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Label-free fluorescent sensing of protease activity
­Summary The current technology offers advantages over existing protease probes, with lower background noise, simplified label-free synthesis, compatibility with any protease of interest and utility for translational research and clinical diagnostics. Technology Overview Dysregulated proteolytic activity is linked to many human diseases, including...
Published: 1/18/2023   |   Inventor(s): Adem Yildirim, Bruce Branchaud, Justin Plaut, Srivathsan Ranganathan, Sean Speese, Corey Dambacher, Sarah Barnhill, Emma Olson
Keywords(s): Diagnostics, Imaging, Imaging - Other, Research Tools
Category(s): Imaging, Research Tools, Diagnostics
Improved removal of projection artifacts in optical coherence tomographic angiography
­Summary The current algorithm improves projection artifacts removal for more accurate optical coherence tomographic angiography (OCTA) scans and better quantitative detection and monitoring of vascular abnormalities. Technology Overview Projection artifacts are one of the significant limitations of OCTA imaging, and a reliable projection-resolved...
Published: 12/6/2022   |   Inventor(s): Yali Jia, Jie Wang
Keywords(s): Diagnostics, Diagnostics - Other, Imaging, Imaging - Other
Category(s): Imaging, Diagnostics
Software for deep learning-based inference of biomarker distribution in cancer samples
Summary Multiplexed tissue imaging (MTI) is a powerful tool for cancer pathology, but it is also expensive, which has limited its availability for underserved communities, particularly in the developing world. The current software uses hematoxylin & eosin (H&E) staining, which is more widely available, to predict oncology biomarker distribution,...
Published: 12/2/2022   |   Inventor(s): Young Hwan Chang, Erik Burlingame, Geoffrey Schau, Elliot Gray
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Diagnostics, Software
Framework for 3D retinal pathology detection by OCT/OCT-angiography
​​Summary The current technology provides a platform for a fully-automated OCT-based 3D detection of retinal pathologies with significantly reduced processing requirements, which could allow for more wide-spread adoption of OCT/OCT-angiography 3D analysis. Technology Overview Optical coherence tomography (OCT) and its angiography can be used to provide...
Published: 10/14/2022   |   Inventor(s): Yali Jia, Shaohua Pi
Keywords(s): Diagnostics, Imaging, Software, Software - Diagnostic/Detection
Category(s): Diagnostics, Imaging, Software
Fully-automated diabetic retinopathy (DR) screening based on OCT and its angiography
Summary The current technology provides a framework for a fully-automated deep-learning-based diabetic retinopathy screening that relies solely on optical coherence tomography (OCT) and its angiography, without the need for fundus photography or time-intensive clinical evaluation. Technology Overview Diabetic retinopathy (DR) is a leading cause of...
Published: 10/14/2022   |   Inventor(s): Yali Jia, Pengxiao Zang
Keywords(s): Diagnostics, Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Diagnostics, Imaging, Software
Universal nanoprobes for imaging and treatment of cancer
Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection...
Published: 8/16/2022   |   Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Imaging, Therapeutics
OCT-based artificial intelligence for irregular cornea classification
Summary ­The current technology provides for an OCT-based artificial intelligence (AI) algorithm to improve classification and diagnosis between common corneal shape abnormalities including forme fruste (pre-clinical) keratoconus (FFK), contact lens related warpage, dry eye disease, and Fuch’s endothelial dystrophy. Technology Overview Keratoconus...
Published: 7/14/2022   |   Inventor(s): David Huang, Yan Li, Elias Pavlatos, Xubo Song
Keywords(s): Diagnostics, Diagnostics - Other, Imaging, Imaging - Other
Category(s): Diagnostics, Imaging
Software for automated identification and segmentation of perivascular spaces on MRI
Summary Enlarged perivascular spaces (ePVS) in the brain are linked to several diseases, but detection at the resolution of clinical MRI relies on manual visual assessment, which are subjective, time-intensive and prone to error. The software automates ePVS detection in several commonly acquired MRI contrasts to increase efficiency and objectivity...
Published: 2/16/2022   |   Inventor(s): Erin Boespflug, Daniel Schwartz, Lisa Silbert, David Lahna
Keywords(s): Imaging, Imaging - MRI, Software, Software - Diagnostic/Detection, Software - Other
Category(s): Imaging, Software
Sensorless adaptive optics (AO) control method for OCT/OCT-angiography retinal imaging
Summary Researchers have developed an improved method of adaptive optics for OCT/OCT-angiography retinal scanning that is sensorless and allows for optical aberrations correction without considerably increasing scan times. Technology Overview Adaptive optics OCT (AO-OCT) allows for high lateral resolution imaging of the retinal tissue and blood flow...
Published: 1/19/2022   |   Inventor(s): Yifan Jian, Acner Camino Benech
Keywords(s): Imaging, Imaging - Other
Category(s): Imaging
Fluorophores for multicolor microscopy
SummaryMulticolor microscopy can be used to localize and visualize complex subcellular systems, but current systems are often limited in the number of fluorophores that can be imaged simultaneously. Oregon Health & Science University researchers have developed novel fluorophores that increase the number of channels and subcellular structures that...
Published: 12/2/2021   |   Inventor(s): Summer Dowell (Gibbs), Amy Bittel, Xiaolin Nan
Keywords(s): Imaging, Research Tools, Research Tools - Reagents
Category(s): Imaging, Research Tools
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