Search Results - therapeutics

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Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Mutation-Specific Treatment Strategies for Acute Myeloid Leukemia
Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics, Diagnostics
Anti-cancer Compounds with Improved Cardiac Safety and Drug Resistance Profiles
SummaryTyrosine kinase inhibitors are effective targeted anti-cancer therapeutics, but currently available inhibitors have limitations due to drug resistance and cardiotoxic effects. Oregon Health & Science University researchers have developed a class of kinase inhibitors with an improved cardiovascular safety profile and the potential to overcome...
Published: 9/7/2021   |   Inventor(s): Sanjay Malhotra, Mallesh Pandrala, Dhanir Tailor, Mark Mercola, Arne Antoon Bruyneel
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
A first in class small molecule as a novel YB1 inhibitor.
SummaryThe development of resistance to chemotherapy treatment in solid tumors is associated with up-regulation of the DNA/RNA binding protein Y box binding protein 1 (YB-1) and a worsened prognosis for cancer patients. Oregon Health & Science University researchers have developed a first-in-class small molecule inhibitor of YB-1 that synergizes...
Published: 9/7/2021   |   Inventor(s): Sanjay Malhotra, Dhanir Tailor
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
Compositions for treatment of neurological and oxidative stress disorders
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 6/22/2021   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
Nanoparticle ultrasound contrast agents with high acoustic activity
SummaryContrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 2/24/2021   |   Inventor(s): Adem Yildirim, Jose Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
A strong micro-promoter for AAV
Summary Viral mediated transgene delivery often utilizes specialized promoters that drive ubiquitous expression; however, these promoters are large and limit the amount of remaining space in AAV vectors for the transgene. The laboratory of Dr. Markus Grompe at OHSU has identified a novel promoter, which drives strong expression in multiple cell types...
Published: 10/9/2020   |   Inventor(s): Markus Grompe, Sunghee Chai
Keywords(s): Biological Materials, Therapeutics
Category(s): Biological Materials, Therapeutics
POMC transgenic mice and neuron-specific promoter
Technology OverviewPOMC neurons of the hypothalamus are critical components of the neural circuitry controlling appetite, feeding, and metabolism. In addition they modulate the activity of other hypothalamic neurons which control reproduction, thyroid hormone levels, growth hormone secretion and neuroendocrine stress responses. Genetic evidence in humans...
Published: 9/16/2020   |   Inventor(s): Malcolm Low, Marcelo Rubinstein, Flavio Silva De Souza
Keywords(s): Biological Materials, Biological Materials - Mice, Therapeutics, Therapeutics - Neurology
Category(s): Research Tools
Adaptive Exercise-Enabled Proportional-Derivative Artificial Pancreas Control Algorithm
This is an adaptive proportional-derivative (APD) control algorithm that provides automated delivery amounts of insulin and optionally glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. The APD algorithm includes a safety layer decision tree to prevent dosing of...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Adaptive Exercise-Enabled Model-Predictive-Control Artificial Pancreas Control Algorithm
SummaryArtificial pancreas devices help maintain healthy glucose levels in patients with type 1 diabetes (T1D), but incidences of hypoglycemia are still common after episodes of eating, sleeping and exercise. Oregon Health & Science University researchers have developed an algorithm that features adaptive responses to these factors as well as individual...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
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