Search Results - therapeutics

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A strong mini-promoter for AAV
SummaryViral mediated transgene delivery often utilizes specialized promoters that drive ubiquitous expression; however, these promoters are large and limit the amount of remaining space in AAV vectors for the transgene. The laboratory of Dr. Markus Grompe at OHSU has identified a novel promoter, which drives strong expression in multiple cell types...
Published: 10/9/2020   |   Inventor(s): Markus Grompe, Sunghee Chai
Keywords(s): Biological Materials, Therapeutics
Category(s): Biological Materials, Therapeutics
Thyronamines: novel bioactive metabolites of thyroid hormone
NOVEL BIOACTIVE METABOLITES OF THYROID HORMONE: A SAFE AND EFFECTIVE TREATMENT FOR DISEASEOHSU Technology 0674Researchers at Oregon Health & Science University and University of California, San Francisco discovered and validated a new class of thyroid hormone metabolites. The most potent of these, 3-iodothyronamine, has been shown in animal studies...
Published: 9/16/2020   |   Inventor(s): Thomas Scanlan, David Grandy, James Bunzow, Katherine Suchland, Matthew Hart, Edwin Tan, Mononori Miyakawa
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Endocrine
Category(s): Therapeutics
POMC transgenic mice and neuron-specific promoter
Technology OverviewPOMC neurons of the hypothalamus are critical components of the neural circuitry controlling appetite, feeding, and metabolism. In addition they modulate the activity of other hypothalamic neurons which control reproduction, thyroid hormone levels, growth hormone secretion and neuroendocrine stress responses. Genetic evidence in humans...
Published: 9/16/2020   |   Inventor(s): Malcolm Low, Marcelo Rubinstein, Flavio Silva De Souza
Keywords(s): Biological Materials, Biological Materials - Mice, Therapeutics, Therapeutics - Neurology
Category(s): Research Tools
Adaptive Exercise-Enabled Proportional-Derivative Artificial Pancreas Control Algorithm
This is an adaptive proportional-derivative (APD) control algorithm that provides automated delivery amounts of insulin and optionally glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. The APD algorithm includes a safety layer decision tree to prevent dosing of...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Adaptive Exercise-Enabled Model-Predictive-Control Artificial Pancreas Control Algorithm
This is a model-predictive control (MPC) algorithm that provides automated delivery amounts of insulin and, optionally, glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. Dosing insulin after meals can be challenging and can lead to hyperglycemia or late-term hypoglycemia...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Method of Producing Human Pluripotent Stem Cells by Somatic Cell Nuclear Transfer
This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). PSC’s only naturally exist in early human embryos. Methods are described to produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin cells as a starting point. Human PSC’s...
Published: 8/5/2020   |   Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana
Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
Small molecule activates innate immune responses controlled by the human protein STING.
Researchers at OHSU have discovered a novel small molecule agonist of human protein STING that may be administered either as an adjuvant to a vaccine or as independent therapy for treatment of infectious disease and/or cancer.
Published: 6/30/2020   |   Inventor(s): Victor DeFilippis, Jinu Abraham, Sara Botto
Keywords(s): Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Vaccines, Therapeutics
Compounds that bind macrophage migration inhibitory factor
Technology Summary:Recombinant polypeptide composition for treatment of progressive multiple sclerosis (MS). This peptide approach selectively blocks key pro-inflammatory factors that could stop MS progression. Derived from CD74, the new composition competes for binding of the CD74 ligand, macrophage migration inhibitory factor (MIF). CD74 is a chaperone...
Published: 3/1/2016   |   Inventor(s): Arthur Vandenbark, Gil Benedek, Roberto Meza-Romero
Keywords(s): Therapeutics, Therapeutics - Immunology
Category(s): Therapeutics
Small Molecule Inhibitors of the Mitochondrial Permeability Transition Pore (PTP)
Compositions for Treatment of Neurological and Oxidative Stress DisordersResearchers at Oregon Health & Science University and Kansas University discovered novel small molecule inhibitors of mitochondrial permeability transition pore (mtPTP) for treatment of cellular disorders associated with an over-accumulation of mitochondrial calcium or reactive...
Published: 2/2/2015   |   Inventor(s): Michael Forte, Dennis Bourdette, Paolo Bernardi, Justina Sileikyte, Frank Schoenen, Sudeshna Roy
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
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