Search Results - therapeutics

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microRNA mimics and inhibitors to modulate genotoxic stress for cancer and aging related diseases.
MicroRNAs (miRs) can regulate gene expression and are often critical players in controlling cellular DNA repair mechanisms. miRs can therefore provide an alternative therapeutic strategy for treatment of cancer and other diseases associated with altered miR expression and/or DNA damage repair.Researchers at OHSU have identified a cohort of miRs tha...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Maria (cristina) Espinosa-Diez
Keywords(s): Diagnostics, Therapeutics
Category(s): Diagnostics, Therapeutics
DRĪ±1-MOG-35-55 treatment of Traumatic Brain Injury
Treatment of traumatic brain injury is limited to medications to limit secondary damage to the brain, surgery to relieve pressure on the brain, and rehabilitation. The OHSU discovery uses a proprietary construct comprised of the human leukocyte antigen (HLA)-DRα1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 con...
Published: 3/20/2017   |   Inventor(s): Halina Offner-Vandenbark, Arthur Vandenbark
Keywords(s): Therapeutics, Therapeutics - Neurology
Category(s): Therapeutics
Compounds that bind macrophage migration inhibitory factor
Compositions for recombinant polypeptides derived from CD74, a chaperone that assists with the folding and trafficking of Class II MHC (Major Histocompatibility Complex), that compete for binding of the CD74 ligand macrophage migration inhibitory factor (MIF). Possible use as a therapeutic to block inflammation driven by MIF interactions with CD 74...
Published: 3/1/2016   |   Inventor(s): Arthur Vandenbark, Gil Benedek, Roberto Meza-Romero
Keywords(s): Therapeutics, Therapeutics - Immunology
Category(s): Therapeutics
The use of PD-1, LAG-3 and TIGIT as biomarkers of HIV persistence during antiretroviral therapy
Value Proposition: Antiretroviral therapy (ART) reduces HIV replication but does not cure HIV. The persistence of HIV in a small pool of long-lived latently infected resting CD4 T cells is a major barrier to viral eradication. Identification of cellular markers that are preferentially expressed at the surface of latently infected cells paves the wa...
Published: 1/15/2016   |   Inventor(s): Remi Fromentin, Nicolas Chomont, Rafick Sekaly
Keywords(s): Diagnostics, Diagnostics - Infectious Disease, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Vaccines, Diagnostics
Thyronamines: novel bioactive metabolites of thyroid hormone
NOVEL BIOACTIVE METABOLITES OF THYROID HORMONE: A SAFE AND EFFECTIVE TREATMENT FOR DISEASEOHSU Technology 0674Researchers at Oregon Health & Science University and University of California, San Francisco discovered and validated a new class of thyroid hormone metabolites. The most potent of these, 3-iodothyronamine, has been shown in animal stu...
Published: 7/22/2015   |   Inventor(s): Thomas Scanlan, David Grandy, James Bunzow, Katherine Suchland, Matthew Hart, Edwin Tan, Mononori Miyakawa
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Endocrine
Category(s): Therapeutics
Small Molecule Inhibitors of the Mitochondrial Permeability Transition Pore (PTP)
Compositions for Treatment of Neurological and Oxidative Stress DisordersResearchers at Oregon Health & Science University and Kansas University discovered novel small molecule inhibitors of mitochondrial permeability transition pore (mtPTP) for treatment of cellular disorders associated with an over-accumulation of mitochondrial calcium or rea...
Published: 2/2/2015   |   Inventor(s): Michael Forte, Dennis Bourdette, Paolo Bernardi, Justina Sileikyte, Frank Schoenen, Sudeshna Roy
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
Oligonucleotides for Long QT Syndrome
Oligonucleotides to prevent poly(A) adenylation at intron 9 of the KCNH2 gene, and pharmaceutical compositions comprising the oligonucleotides and methods to use same to treat long QT syndrome. Included are antisense sequences to specific sites in intron 9. KCNH2, also known as ether-a-go-go related gene 1 (hERG1) encodes the Kv11.1 channel that co...
Published: 1/29/2015   |   Inventor(s): Zhengfeng Zhou, Qiuming Gong, Matthew Stump
Keywords(s): Therapeutics, Therapeutics - General, Therapeutics - Other
Category(s): Therapeutics
Biochemical Stabilization of Glucagon
Glucagon formulation for closed-loop Type 1 diabetes management systemsA proprietary, stable formulation of glucagon has been developed at OHSU for use in closed loop glycemic management systems comprising sensors and pumps. Ideally, small doses of glucagon need to be kept in a portable pump for 3 days at room temperature to body temperature for s...
Published: 1/29/2015   |   Inventor(s): William (kenneth) Ward, Nicholas Caputo, Jessica Castle, Parkash Bakhtiani
Keywords(s): Biological Materials, Therapeutics
Category(s): Biological Materials, Chemical
Compounds for treating parasitic disease.
Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of compounds that are superior to the standard of care. The antimalarial agents are effective at inhibiting proliferation of multi-drug resistant malarial parasites and selected members of this potent class ar...
Published: 9/24/2014   |   Inventor(s): Michael Riscoe, Rolf Winter, David Hinrichs
Keywords(s): Diagnostics, Diagnostics - Infectious Disease, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Chemical, Therapeutics
Hydrolysis-Resistant Local Anesthetics
CNG CHANNEL BLOCKERSFOR TREATMENT OF RETINAL DISEASEOHSU Technology 1684To meet a pressing need for better cyclic nucleotide-gated (CNG) channel antagonists, Researchers at Oregon Health & Science University and Willamette University designed, synthesized and determined the apparent affinities and mechanism of CNG channel block with novel hydro...
Published: 5/1/2013   |   Inventor(s): Jeffrey Karpen, Sarah Kirk, Adriana Andrade, Kenneth Melich, Michelle Schaffer
Keywords(s): Therapeutics
Category(s): Therapeutics, Chemical
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