Search Results - therapeutics

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Covalent inhibitors of PARP-16 for cancer treatment

Summary The current technology is a selective, covalent inhibitor of PARP16 with potential therapeutic applications for the treatment of cancer. Technology Overview The poly-ADP-ribose-polymerase (PARP) family is made up of 17 enzymes in humans that are increasingly recognized as major downstream regulators of NAD+-mediated signaling in cells. PARP1...

Published: 2/12/2024 | Inventor(s): Michael Cohen, Daniel Bejan, Sunil Sundalam

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

CD74 as a biomarker and therapeutic target for familial platelet (FPD) disorder

Summary Research at OHSU has identified the CD74 signaling cascade as a potential therapeutic target and diagnostic biomarker for RUNX1-mutated familial platelet disorder (FPD), which is a premalignant condition for acute myeloid leukemia. Technology Overview Current estimates suggest as many as 18,000 people may be living with RUNX1-FPD in the United...

Published: 2/27/2024 | Inventor(s): Anupriya Agarwal, Mona Mohammadhosseini

Keywords(s): Diagnostics, Diagnostics - Cancer, Diagnostics - Other, Therapeutics, Therapeutics - Cancer, Therapeutics - Other

Category(s): Diagnostics, Therapeutics

Nanoparticle ultrasound contrast agents with high acoustic activity

Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...

Published: 11/22/2023 | Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics

Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics

A method of enhancing cancer immunotherapies through androgen receptor modulation

Summary The current technology has the potential to enhance the effectiveness of checkpoint blockade for advanced prostate cancer patients by directly enhancing T cell function through a reduction in intrinsic androgen receptor signaling. Technology Overview In many patients with advanced cancer, immunotherapy treatments have largely failed....

Published: 9/27/2023 | Inventor(s): Fanny Polesso, Amy Moran

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Selective PARP11 inhibitor for the treatment of cancer

Summary The current technology is a highly selective and potent inhibitor of PARP11 that could serve as an immuno-oncology therapeutic and enhance CAR-T cell therapies. Technology Overview Recent work identified PARP11 as a key component in driving tumor microenvironments (Nature Cancer, 2022), and suppression of PARP11 augmented the therapeutic...

Published: 11/6/2023 | Inventor(s): Michael Cohen, Ilsa Kirby

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Photoactivatable modulation of antibody binding

Summary The current technology involves a blocking construct that has the potential to increase antibody specificity and reduce unwanted off-target effects by modulating antibody activation in a manner that is predictable, reproducible and does not require genetic modification of the antibody sequence. Technology Overview Traditional antibodies...

Published: 9/21/2023 | Inventor(s): Stuart Ibsen, Michael Brasino

Keywords(s): Diagnostics, Therapeutics

Category(s): Diagnostics, Therapeutics

Universal nanoprobes for imaging and treatment of cancer

Summary Medical imaging is currently incapable of detecting very small tumors and there is a need for new contrast agents that allow for earlier detection of cancers. The current technology is a self-assembled nanoprobe that specifically accumulates in a broad range of solid tumors to enable 1) high-resolution imaging for earlier cancer detection and...

Published: 9/21/2023 | Inventor(s): Adem Yildirim, Jared Fischer, Bruce Branchaud

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Therapeutics, Therapeutics - Cancer

Category(s): Diagnostics, Imaging, Therapeutics

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation

HEADLINE: Novel protein induces pancreatic beta cell proliferation, is ideal for diabetes treatment research Our scientists discovered a novel protein that offers a potential new avenue of research for labs developing drugs to treat diabetes. The newly-discovered BefA (β Cell Expansion Factor A) protein acts to increase total pancreatic...

Published: 10/19/2023 | Inventor(s): Karen Guillemin, Jennifer Hampton

Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish

Category(s): Diagnostics, Therapeutics, Research Tools

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity

HEADLINE: Novel protein with strong anti-inflammatory activity has been shown to effectively treat inflammatory bowel disease and prevent septic shock in zebrafish. University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel...

Published: 5/2/2022 | Inventor(s): Karen Guillemin, Annah Rolig

Keywords(s): Biochemistry, Biological Materials, Biotech, Research Tools, Therapeutics, Zebrafish

Category(s): Research Tools, Therapeutics, Agricultural, Diagnostics

Methods of treating venetoclax-resistant acute myeloid leukemia

SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...

Published: 9/19/2023 | Inventor(s): Jeffrey (Jeff) Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher (Chris) Eide, Ravindra Majeti

Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer

Category(s): Diagnostics, Therapeutics

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