Search Results - therapeutics

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Adaptive Exercise-Enabled Proportional-Derivative Artificial Pancreas Control Algorithm
This is an adaptive proportional-derivative (APD) control algorithm that provides automated delivery amounts of insulin and optionally glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. The APD algorithm includes a safety layer decision tree to prevent dosing of...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Adaptive Exercise-Enabled Model-Predictive-Control Artificial Pancreas Control Algorithm
This is a model-predictive control (MPC) algorithm that provides automated delivery amounts of insulin and, optionally, glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. Dosing insulin after meals can be challenging and can lead to hyperglycemia or late-term hypoglycemia...
Published: 8/13/2020   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Method of Producing Human Pluripotent Stem Cells by Somatic Cell Nuclear Transfer
This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). PSC’s only naturally exist in early human embryos. Methods are described to produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin cells as a starting point. Human PSC’s...
Published: 8/5/2020   |   Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana
Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
Small molecule activates innate immune responses controlled by the human protein STING.
Researchers at OHSU have discovered a novel small molecule agonist of human protein STING that may be administered either as an adjuvant to a vaccine or as independent therapy for treatment of infectious disease and/or cancer.
Published: 6/30/2020   |   Inventor(s): Victor DeFilippis, Jinu Abraham, Sara Botto
Keywords(s): Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Vaccines, Therapeutics
microRNA mimics and inhibitors to modulate genotoxic stress for cancer and aging related diseases.
MicroRNAs (miRs) can regulate gene expression and are often critical players in controlling cellular DNA repair mechanisms. miRs can therefore provide an alternative therapeutic strategy for treatment of cancer and other diseases associated with altered miR expression and/or DNA damage repair.Researchers at OHSU have identified a cohort of miRs that...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Maria (cristina) Espinosa-Diez
Keywords(s): Diagnostics, Therapeutics
Category(s): Diagnostics, Therapeutics
DRĪ±1-MOG-35-55 treatment of Traumatic Brain Injury
Treatment of traumatic brain injury is limited to medications to limit secondary damage to the brain, surgery to relieve pressure on the brain, and rehabilitation. The OHSU discovery uses a proprietary construct comprised of the human leukocyte antigen (HLA)-DRα1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 construct)...
Published: 3/20/2017   |   Inventor(s): Halina Offner-Vandenbark, Arthur Vandenbark
Keywords(s): Therapeutics, Therapeutics - Neurology
Category(s): Therapeutics
Compounds that bind macrophage migration inhibitory factor
Compositions for recombinant polypeptides derived from CD74, a chaperone that assists with the folding and trafficking of Class II MHC (Major Histocompatibility Complex), that compete for binding of the CD74 ligand macrophage migration inhibitory factor (MIF). Possible use as a therapeutic to block inflammation driven by MIF interactions with CD 74....
Published: 3/1/2016   |   Inventor(s): Arthur Vandenbark, Gil Benedek, Roberto Meza-Romero
Keywords(s): Therapeutics, Therapeutics - Immunology
Category(s): Therapeutics
The use of PD-1, LAG-3 and TIGIT as biomarkers of HIV persistence during antiretroviral therapy
Value Proposition: Antiretroviral therapy (ART) reduces HIV replication but does not cure HIV. The persistence of HIV in a small pool of long-lived latently infected resting CD4 T cells is a major barrier to viral eradication. Identification of cellular markers that are preferentially expressed at the surface of latently infected cells paves the way...
Published: 1/15/2016   |   Inventor(s): Remi Fromentin, Nicolas Chomont, Rafick Sekaly
Keywords(s): Diagnostics, Diagnostics - Infectious Disease, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Vaccines, Diagnostics
Thyronamines: novel bioactive metabolites of thyroid hormone
NOVEL BIOACTIVE METABOLITES OF THYROID HORMONE: A SAFE AND EFFECTIVE TREATMENT FOR DISEASEOHSU Technology 0674Researchers at Oregon Health & Science University and University of California, San Francisco discovered and validated a new class of thyroid hormone metabolites. The most potent of these, 3-iodothyronamine, has been shown in animal studies...
Published: 7/22/2015   |   Inventor(s): Thomas Scanlan, David Grandy, James Bunzow, Katherine Suchland, Matthew Hart, Edwin Tan, Mononori Miyakawa
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Endocrine
Category(s): Therapeutics
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