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Covalent inhibitors of PARP-16 for cancer treatment

Summary The current technology is a selective, covalent inhibitor of PARP16 with potential therapeutic applications for the treatment of cancer. Technology Overview The poly-ADP-ribose-polymerase (PARP) family is made up of 17 enzymes in humans that are increasingly recognized as major downstream regulators of NAD+-mediated signaling in cells. PARP1...

Published: 2/12/2024 | Inventor(s): Michael Cohen, Daniel Bejan, Sunil Sundalam

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics