Search Results - michael+pluth

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Biological H2S / COS Donation by Thiocarbamates

1. Technology Overview The invention focuses on biological hydrogen sulfide (H₂S) and carbonyl sulfide (COS) donation using thiocarbamates. These compounds release COS, which is then converted to H₂S by hydrolysis or metabolism by carbonic anhydrase. The technology is currently in the development stage, with promising cross-industry applications in...

Published: 1/7/2026 | Inventor(s): Michael Pluth, Andrea Steiger, Yu Zhao

Keywords(s):

Category(s): Chemistry, Physical Science, Therapeutics

Method for Detection for Hydrosulfide Anion (HS-) and Hydrogen Sulfide (H2S)

1. Technology Overview The invention focuses on a new method for detecting hydrosulfide anion (HS⁻) and hydrogen sulfide (H₂S) using reversible, supramolecular binding interactions. This method utilizes non-covalent interactions, specifically hydrogen bonds, to detect HS⁻/H₂S without altering the analyte concentration. The technology is currently...

Published: 1/7/2026 | Inventor(s): Michael Haley, Darren Johnson, Michael Pluth, Ryan Hansen, Matt Hartle, Blakely Tresca

Keywords(s):

Category(s): Chemistry, Materials Science, Physical Science, Imaging, Therapeutics, Research Tools, Diagnostics

Compounds for Thiol-Triggered COS and/or H2S Release and Methods of Making and Using the Same

1. Technology Overview The invention focuses on thiol-triggered sulfenyl thiocarbonates and sulfenyl thiocarbamates that release carbonyl sulfide (COS) and hydrogen sulfide (H₂S) in the presence of biologically relevant thiols. These compounds offer a concomitant fluorescence response, providing optical indication of COS and H₂S release. The technology...

Published: 1/2/2026 | Inventor(s): Michael Pluth, Yu Zhao, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Engineering, Medical Devices, Physical Science, Therapeutics

Thionoesters that Release H2S upon Thiol Ligation

1. Technology Overview The invention focuses on synthesizing thionoesters that release hydrogen sulfide (H₂S) upon thiol ligation. These small molecules react with L-cysteine and other cysteine derivatives to release H₂S, terminating in the formation of N-benzoyl-L-cysteine. The technology is currently in the development stage, with promising cross-industry...

Published: 1/7/2026 | Inventor(s): Michael Pluth, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Diagnostics, Medical Devices, Physical Science, Therapeutics