Search Results - research+tools

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Label-free fluorescent sensing of protease activity
­Summary The current technology offers advantages over existing protease probes, with lower background noise, simplified label-free synthesis, compatibility with any protease of interest and utility for translational research and clinical diagnostics. Technology Overview Dysregulated proteolytic activity is linked to many human diseases, including...
Published: 1/18/2023   |   Inventor(s): Adem Yildirim, Bruce Branchaud, Justin Plaut, Srivathsan Ranganathan, Sean Speese, Corey Dambacher, Sarah Barnhill, Emma Olson
Keywords(s): Diagnostics, Imaging, Imaging - Other, Research Tools
Category(s): Imaging, Research Tools, Diagnostics
Spatially-resolved transcriptomics with enhanced capture and versatility
Summary An improved platform for spatial transcriptomics, which could be mass produced and would allow for overall increased detection of transcripts, including for lower-expressed sequences. Technology Overview Spatial transcriptomics allows for the measurement of gene activity within a sample while mapping where that activity is occurring; however,...
Published: 12/6/2022   |   Inventor(s): Yu-Jui (Roger) Chiu, Fehmi Civitci, Eugene Tu
Keywords(s): Next Generation Sequencing, Research Tools
Category(s): Research Tools
Label-free microfluidic device for cancer liquid biopsy
Summary Liquid biopsies offer a less invasive method of early cancer detection; however, circulating cancer cells are rare and difficult to detect. The current technology is a device that allows for sensitive, label-free enrichment of circulating neoplastic cells in order to facilitate the detection of cancer biomarkers from peripheral blood samples. Technology...
Published: 8/16/2022   |   Inventor(s): Yu-Jui (Roger) Chiu, Ajay Sapre, Jose Luis Montoya Mira, Kyle Gustafson
Keywords(s): Device, Device - Other, Diagnostics, Diagnostics - Cancer, Research Tools
Category(s): Diagnostics, Research Tools, Device
Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity
HEADLINE: Novel protein with strong anti-inflammatory activity has been shown to effectively treat inflammatory bowel disease and prevent septic shock in zebrafish. University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel...
Published: 5/2/2022   |   Inventor(s): Karen Guillemin, Annah Rolig
Keywords(s): Biochemistry, Biological Materials, Biotech, Research Tools, Therapeutics, Zebrafish
Category(s): Research Tools, Therapeutics, Agricultural, Diagnostics
Fluorophores for multicolor microscopy
SummaryMulticolor microscopy can be used to localize and visualize complex subcellular systems, but current systems are often limited in the number of fluorophores that can be imaged simultaneously. Oregon Health & Science University researchers have developed novel fluorophores that increase the number of channels and subcellular structures that...
Published: 12/2/2021   |   Inventor(s): Summer Dowell (Gibbs), Amy Bittel, Xiaolin Nan
Keywords(s): Imaging, Research Tools, Research Tools - Reagents
Category(s): Imaging, Research Tools
Cell-permeant and water-soluble rhodamine dyes for quantitative imaging applications
SummaryRhodamines are a class of fluorescent proteins (FP) that stand out for their higher photostability and brightness as well as easier synthesis compared to other FPs; however, classic rhodamines generally have poor water solubility and tend to aggregate in an aqueous environment. Oregon Health & Science University researchers have developed...
Published: 7/1/2022   |   Inventor(s): Summer Dowell (Gibbs), Lei Wang, Antonio Montano
Keywords(s): Imaging, Imaging - Other, Research Tools, Research Tools - Reagents
Category(s): Imaging, Research Tools
Improved detection of heart-rate variability for wearable devices
Summary Heart-rate variability (HRV) is a suggested marker of the autonomic nervous system, but artifacts produced by movement with wrist worn devices decreases the validity and utility of this data. Oregon Health & Science University researchers have developed an improved method of removing motion artifacts, understanding the amount of data that...
Published: 4/20/2022   |   Inventor(s): David Sheridan, Steven Baker, Ryan Dehart
Keywords(s): Diagnostics, Research Tools, Software
Category(s): Diagnostics, Research Tools, Software
RadSearch: a radiology report search engine
Summary Harnessing the power of large databases is contingent upon the ability to access datapoints efficiently and accurately; however, this has proven difficult in the field of radiology where complex visual and written records must be integrated. Oregon Health & Science University research has led to the development of a novel radiology-specific...
Published: 9/23/2021   |   Inventor(s): Ningcheng (Peter) Li
Keywords(s): Research Tools, Software
Category(s): Software, Research Tools
Audio/visual information from semi-structured conversations paired with cognitive clinical data
SummaryA rare dataset containing high quality audio and visual information from semi-structured videocall conversations that is paired with cognitive clinical data and weekly surveys assessing social engagement and psychological well-being.Technology OverviewVideocall formats offer the opportunity to easily record visual and audio information to assess...
Published: 11/23/2021   |   Inventor(s): Hiroko Dodge
Keywords(s): Research Tools
Category(s): Multimedia, Research Tools, Speech & Language
Videochat materials for enhancing cognitive functions among seniors
Summary An Oregon Health & Science University (OHSU) researcher has developed a series of visual and written prompts, compatible with videochat formats, to enhance cognitive function and decrease social isolation in seniors. Technology Overview Forty-seven million people are currently living with dementia and this population is projected to...
Published: 8/12/2021   |   Inventor(s): Hiroko Dodge
Keywords(s): Education & Training, Education & Training - Psychology, Research Tools
Category(s): Multimedia, Speech & Language
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