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This is the incline ramp tool used in the BESTest-10 degree incline ramp (at least 2 x 2 ft) to stand on. To acquire the BESTest training DVD in addition to this tool, please see: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=217191

Published: April 28, 2010 | Inventor(s): Fay Horak

Keywords(s): Diagnostics - Neurology, Education & Training, Research Tools - Screening, Diagnostics, Education & Training - Clinical, Research Tools

Category(s): Education & Training

BESTest medium density foam block tool

This is the foam block tool used in the BESTest- approximately 60 cm x 60 cm (2 X 2 ft) block of 4-inch, medium-density, Tempur® foam. To acquire the BESTest training DVD in addition to this tool, please see: http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=217191

Published: April 28, 2010 | Inventor(s): Fay Horak

Keywords(s): Diagnostics - Neurology, Education & Training, Research Tools - Screening, Diagnostics, Education & Training - Clinical, Research Tools

Category(s): Education & Training

BB19 Cell Line

Technology OverviewThe inventors developed an immortalized human brain capillary endothelial cell line named BB19. BB19 cells are derived from human brain endothelium and are immortalized with E6E7 genes of human papilloma virus. This cell line has been used to study cytoadherence of Plasmodium falciparum-infected erythrocytes in vitro. ...

Published: April 28, 2010 | Inventor(s): Jay Nelson, Ashlee Moses

Keywords(s): Biological Materials - Cell Lines, Research Tools - Screening, Biological Materials, Research Tools

Category(s): Biological Materials

CtBP1, CtBP2, PARP-1, PARP-2 and Chk-1 Knockdown Stable Cell Lines

Technology OverviewA number of cell lines have been produced to knockdown single or multiple isoforms of specific genes by siRNA so that their promoter specific effects could be studies. These various cell lines were used in order to study regulation of the p21 promoter, the E-cadherin promoter, and cell cycle checkpoint gene regulation in r...

Published: April 28, 2010 | Inventor(s): Dana Madison, James Lundblad, Damian Curtis

Keywords(s): Biological Materials - Cell Lines, Research Tools - Reagents, Biological Materials, Research Tools

Category(s): Biological Materials

C-Terminal Binding Protein (CtBP) single isoform lentiviral stable cell lines

Technology OverviewThese cell lines re-introduce CtBP wild type and functional mutant isoforms (both CtBP1 and 2) back into a CtBP1+2 null mouse embryonic fibroblast (MEF) line. These cells contain lentiviral-introduced protein encoding sequences that allow for stable expression of physiologic levels of CtBP isoforms under the tetracycline o...

Published: April 28, 2010 | Inventor(s): Dana Madison, James Lundblad, Damian Curtis

Keywords(s): Biological Materials - Cell Lines, Research Tools - Reagents, Biological Materials, Research Tools

Category(s): Biological Materials

Bacterial artificial chromosome (BAC) clone containing the genome of human cytomegalovirus (HCMV) TR strain

Technology Overview The TR BAC was prepared from the TR clinical HCMV isolate. This virus is resistant to ganciclovir and cidofovir and lacks UL97 codons 591-594. The BAC clone was generated by substituting BAC DNA for the US2-US5 region of the TR genome. The TR strain infects almost any diploid endothelial or epithelial cell as well as macro...

Published: April 28, 2010 | Inventor(s): Jay Nelson, Michael Jarvis

Keywords(s): Biological Materials - DNA/RNA, Research Tools - Reagents, Biological Materials, Research Tools

Category(s): Biological Materials

CyP-D Knock-Out Mice

Technology Overview Cyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies. These animals ...

Published: April 28, 2010 | Inventor(s): Michael Forte, Paolo Bernardi, Emy Basso

Keywords(s): Biological Materials - Mice, Research Tools - Screening, Biological Materials, Research Tools

Category(s): Biological Materials

Novel Mammalian Catecholmine Receptor Genes and Uses

Technology Information This invention encompasses expression of the Trace Amine Associated Receptor 1 (TAAR1) receptor gene in cell culture, and an assay to determine activity of the TAAR1 receptor function in the presence of test compounds. Until now, TAAR1 proteins have been difficult to express and assay in-vitro. The clones and associate...

Published: April 28, 2010 | Inventor(s): James Bunzow, David Grandy, Mark Sonders

Keywords(s): Biological Materials - Receptors/Targets, Research Tools - Screening, Biological Materials, Research Tools

Category(s): Research Tools

Corticotrophin releasing hormone double receptor (CRH-R1/R2) knockout mice

Technology OverviewSignaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and pharmacologically distinct corticotropin releasing factor receptor subtypes (corticotropin releasing factor receptor-1 and corticotropin...

Published: April 28, 2010 | Inventor(s): Mary Stenzel-Poore, Sarah Coste

Keywords(s): Biological Materials - Mice, Research Tools - Screening, Biological Materials, Research Tools

Category(s): Biological Materials

Corticotropin-releasing hormone receptor-2 knockout mice

Technology Overview Several of the critical molecules that mediate the response to stress have recently been identified and cloned, thus providing new molecular tools for studying this process. One of the primary players in neuro-immune regulation is the neuroendocrine hormone, corticotropin-releasing hormone (CRH). This hormone is the centra...

Published: April 28, 2010 | Inventor(s): Mary Stenzel-Poore, Peter Stenzel, Sarah Coste, Robert Kesterson

Keywords(s): Biological Materials - Mice, Research Tools - Screening, Biological Materials, Research Tools

Category(s): Biological Materials

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