Search Results - research+tools

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A microcontroller for easier whole-cell patch clamping on dendrites and axons
Summary The current technology is a microcontroller that allows for the application of controlled negative pressure and simultaneous electrical impulses to make it easier to obtain whole-cell patch clamp recordings on small cellular structures. Technology Overview Whole-cell patch clamping is a technique commonly employed to study the electrical...
Published: 1/30/2024   |   Inventor(s): Stephen Smith, Timur Tsintsadze
Keywords(s): Research Tools, Research Tools - Other
Category(s): Research Tools
Nanoparticle ultrasound contrast agents with high acoustic activity
Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 11/22/2023   |   Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
Rapid antibody conjugation technique
­Summary The current technology is an improved method of antibody conjugation that allows for rapid and scalable antibody labeling, which could be utilized for a number of omics techniques and other antibody-based platforms. Technology Overview In order to label and functionalize antibodies, direct or secondary conjugations are typically employed....
Published: 11/2/2023   |   Inventor(s): Kai Tao, Srivathsan Ranganathan, Emine (Sila) Ozdemir, Matthew Rames, Michael Brasino, Mingchong Dai, Gulsu Sener Yildrim
Keywords(s): Research Tools
Category(s): Research Tools, Proteomics
De novo peptide sequencer
Summary De novo protein-sequencing approaches are poised to revolutionize nearly all fields of biological research and medicine; however current approaches are low-throughput and limited in their sensitivity. The current technology is a novel method that could be implemented with existing reagents and equipment to improve de novo peptide sequencing...
Published: 5/17/2023   |   Inventor(s): Eugene Tu, Fehmi Civitci, Kevin Schilling, Mingchong Dai, Nicholas Groves, Justin Plaut, Srivathsan Ranganathan, Andy Mendoza, Riccardo Carloni, Yu-Jui (Roger) Chiu, Emine (Sila) Ozdemir, Bruce Branchaud
Keywords(s): Research Tools, Research Tools - Other
Category(s): Proteomics, Research Tools
Improved detection of heart-rate variability for wearable devices
Summary Heart-rate variability (HRV) is a suggested marker of the autonomic nervous system, but artifacts produced by movement with wrist worn devices decreases the validity and utility of this data. Oregon Health & Science University researchers have developed an improved method of removing motion artifacts, understanding the amount of data that...
Published: 3/24/2023   |   Inventor(s): David Sheridan, Steven Baker, Ryan Dehart
Keywords(s): Diagnostics, Research Tools, Software
Category(s): Diagnostics, Research Tools, Software
Label-free fluorescent sensing of protease activity
­Summary The current technology offers advantages over existing protease probes, with lower background noise, simplified label-free synthesis, compatibility with any protease of interest and utility for translational research and clinical diagnostics. Technology Overview Dysregulated proteolytic activity is linked to many human diseases, including...
Published: 9/27/2023   |   Inventor(s): Adem Yildirim, Bruce Branchaud, Justin Plaut, Srivathsan Ranganathan, Sean Speese, Corey Dambacher, Sarah Barnhill, Emma Olson
Keywords(s): Diagnostics, Imaging, Imaging - Other, Research Tools
Category(s): Imaging, Research Tools, Diagnostics
Spatially-resolved transcriptomics with enhanced capture and versatility
Summary An improved platform for spatial transcriptomics, which could be mass produced and would allow for overall increased detection of transcripts, including for lower-expressed sequences. Technology Overview Spatial transcriptomics allows for the measurement of gene activity within a sample while mapping where that activity is occurring; however,...
Published: 9/27/2023   |   Inventor(s): Yu-Jui (Roger) Chiu, Fehmi Civitci, Eugene Tu
Keywords(s): Next Generation Sequencing, Research Tools
Category(s): Research Tools
Label-free microfluidic device for cancer liquid biopsy
Summary Liquid biopsies offer a less invasive method of early cancer detection; however, circulating cancer cells are rare and difficult to detect. The current technology is a device that allows for sensitive, label-free enrichment of circulating neoplastic cells in order to facilitate the detection of cancer biomarkers from peripheral blood samples. Technology...
Published: 8/16/2022   |   Inventor(s): Yu-Jui (Roger) Chiu, Ajay Sapre, Jose Luis Montoya Mira, Kyle Gustafson
Keywords(s): Device, Device - Other, Diagnostics, Diagnostics - Cancer, Research Tools
Category(s): Diagnostics, Research Tools, Device
Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity
HEADLINE: Novel protein with strong anti-inflammatory activity has been shown to effectively treat inflammatory bowel disease and prevent septic shock in zebrafish. University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel...
Published: 5/2/2022   |   Inventor(s): Karen Guillemin, Annah Rolig
Keywords(s): Biochemistry, Biological Materials, Biotech, Research Tools, Therapeutics, Zebrafish
Category(s): Research Tools, Therapeutics, Agricultural, Diagnostics
Fluorophores for multicolor microscopy
SummaryMulticolor microscopy can be used to localize and visualize complex subcellular systems, but current systems are often limited in the number of fluorophores that can be imaged simultaneously. Oregon Health & Science University researchers have developed novel fluorophores that increase the number of channels and subcellular structures that...
Published: 12/2/2021   |   Inventor(s): Summer Dowell (Gibbs), Amy Bittel, Xiaolin Nan
Keywords(s): Imaging, Research Tools, Research Tools - Reagents
Category(s): Imaging, Research Tools
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