Search Results - michael+cohen

7 Results

Sort By:

Covalent inhibitors of PARP-16 for cancer treatment

Summary The current technology is a selective, covalent inhibitor of PARP16 with potential therapeutic applications for the treatment of cancer. Technology Overview The poly-ADP-ribose-polymerase (PARP) family is made up of 17 enzymes in humans that are increasingly recognized as major downstream regulators of NAD+-mediated signaling in cells. PARP1...

Published: 2/12/2024 | Inventor(s): Michael Cohen, Daniel Bejan, Sunil Sundalam

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Selective PARP11 inhibitor for the treatment of cancer

Summary The current technology is a highly selective and potent inhibitor of PARP11 that could serve as an immuno-oncology therapeutic and enhance CAR-T cell therapies. Technology Overview Recent work identified PARP11 as a key component in driving tumor microenvironments (Nature Cancer, 2022), and suppression of PARP11 augmented the therapeutic...

Published: 11/6/2023 | Inventor(s): Michael Cohen, Ilsa Kirby

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics

Compositions for treatment of neurological and oxidative stress disorders

Summary Dysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...

Published: 10/3/2022 | Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi

Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other

Category(s): Therapeutics

Small molecules promoting nerve regeneration

Summary Nerve regeneration is critical after an injury for proper healing and restoration of function, but many tissues, such as the heart and spinal cord, lack this capacity due to extensive scarring resulting in more permanent injury and loss of function. Researchers at Oregon Health & Science have discovered novel compounds that promote nerve...

Published: 9/21/2023 | Inventor(s): Michael Cohen, Beth Habecker, Haihong Jin, Ryan Gardner, Matthew Blake

Keywords(s): Therapeutics - Cardiology, Therapeutics - Neurology

Category(s): Therapeutics

Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets

Summary Researchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel...

Published: 9/21/2023 | Inventor(s): Sunil Sundalam, Michael Cohen

Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases

Category(s): Chemical, Research Tools, Therapeutics

Method for identifying Family-Member Specific Targets of Mono-PARPs

Summary Technology developed at OHSU provides a novel method to identify proteins regulated by PARP mono-ADP-ribosylation (MARylation), a post-translational modification carried out by the majority of enzymes within this family. This tool has the ability to link such PARPs to specific targets and broader biological pathways, thereby increasing our understanding...

Published: 9/29/2022 | Inventor(s): Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin

Keywords(s): Diagnostics - Platforms, Research Tools

Category(s): Diagnostics, Proteomics, Research Tools

Novel biosensor for direct measurement of bioavailable NAD+

Summary This technology provides a unique cell-based platform for targeting NAD+-(nicotinamide adenine dinucleotide) regulatory pathways in the treatment of human diseases. An emerging theme in age-related pathologies—e.g. neurodegeneration, cancer, cardiovascular disease, inflammation, type 2 diabetes, and metabolic disease—is due to the...

Published: 9/23/2022 | Inventor(s): Richard Goodman, Michael Cohen, Xiaolu (Lulu) Cambronne, Melissa Stewart

Keywords(s): Research Tools - Screening

Category(s): Research Tools