Search Results - michael cohen

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Small molecule modulators of PTP sigma for nerve regeneration
Researchers at Oregon Health & Science discovered novel compounds that promote nerve regeneration in tissues that otherwise prevent neural growth due to scarring. Nerve injury is a major source of morbidity in the military whether from traumatic brain injury, spinal cord injury, or an extremity injury damaging peripheral nerves. The etiologies of...
Published: 8/31/2020   |   Inventor(s): Michael Cohen, Beth Habecker, Haihong Jin, Ryan Gardner, Matthew Blake
Keywords(s): Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Allosteric Modulation of PARP1-DNA Binding with Small Molecule Inhibitors: A Potential None Synthetic Lethal Therapeutic Strategy for Treating Ewing Sarcoma and Other Solid Tumors for Treating Ewing Sarcoma and Other Solid Tumors
SummaryResearchers at OHSU have developed a novel PARP1 inhibitors that demonstrate a novel dual mode of action to inhibit catalytic activity while also allosterically trapping PARP1 at the DNA binding stage. This strategy offers a significant advantage over existing PARP1 inhibitors by increasing replication stress and cytotoxicity, potentially eliminating...
Published: 7/29/2019   |   Inventor(s): Moriah Arnold, Michael Cohen, Anang Shelat
Keywords(s):  
Category(s): Therapeutics
Method for identifying Family-Member Specific Targets of Mono-PARPs
Summary Technology developed at OHSU provides a novel method to identify proteins regulated by PARP mono-ADP-ribosylation (MARylation), a post-translational modification carried out by the majority of enzymes within this family. This tool has the ability to link such PARPs to specific targets and broader biological pathways, thereby increasing our understanding...
Published: 8/29/2016   |   Inventor(s): Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
Keywords(s): Diagnostics - Platforms, Research Tools
Category(s): Diagnostics, Proteomics, Research Tools
Novel Biosensor for Direct Measurement of Bioavailable NAD+
This technology provides a unique cell-based platform for targeting NAD+-(nicotinamide adenine dinucleotide) regulatory pathways in the treatment of human diseases. An emerging theme in age-related pathologies—e.g. neurodegeneration, cancer, cardiovascular disease, inflammation, type 2 diabetes, and metabolic disease—is due to the misregulation...
Published: 8/28/2015   |   Inventor(s): Richard Goodman, Michael Cohen, Xiaolu (lulu) Cambronne, Melissa Stewart
Keywords(s): Research Tools - Screening
Category(s): Research Tools
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