Search Results - therapeutics - infectious diseases

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The use of PD-1, LAG-3 and TIGIT as biomarkers of HIV persistence during antiretroviral therapy
Value Proposition: Antiretroviral therapy (ART) reduces HIV replication but does not cure HIV. The persistence of HIV in a small pool of long-lived latently infected resting CD4 T cells is a major barrier to viral eradication. Identification of cellular markers that are preferentially expressed at the surface of latently infected cells paves the wa...
Published: 1/15/2016   |   Inventor(s): Remi Fromentin, Nicolas Chomont, Rafick Sekaly
Keywords(s): Diagnostics, Diagnostics - Infectious Disease, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Vaccines, Diagnostics
Compounds for treating parasitic disease.
Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of compounds that are superior to the standard of care. The antimalarial agents are effective at inhibiting proliferation of multi-drug resistant malarial parasites and selected members of this potent class ar...
Published: 9/24/2014   |   Inventor(s): Michael Riscoe, Rolf Winter, David Hinrichs
Keywords(s): Diagnostics, Diagnostics - Infectious Disease, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Chemical, Therapeutics
siRNA sequence and method for treating dengue virus infection
siRNA sequence and method for treating dengue virus infection OHSU Technology 1601 Value Proposition: Dengue virus (DENV) is a leading cause of illness in the tropics and subtropics, with as many as 100 million people infected yearly. Currently, there is no approved vaccine for DENV or any approved antiviral compositions to treat DENV eith...
Published: 10/16/2013   |   Inventor(s): David Stein, Stuart Perry, Sujan Shresta, Klaus Frueh
Keywords(s): Research Tools - Reagents, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Research Tools
Cloroquine Replacement Drugs
Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of compounds that are superior to the standard of care. The antimalarial agents are effective at inhibiting proliferation of multi-drug resistant malarial parasites and selected members of this potent class ar...
Published: 11/5/2012   |   Inventor(s): Michael Riscoe, Rolf Winter, Sovitj Pou, David Hinrichs, Jane Kelly, Yuexin Li, Aaron Nilsen
Keywords(s): Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Chemical
Antiviral Drug Discovery for AIDS: The HIV-1 Vif Protein
Technology OverviewDespite remarkable medical advances, the incidence of HIV infections continues to rise throughout the world. The majority of current HIV therapies target HIV reverse transcriptase or protease, but viral resistance and toxicity have created a need for more potent and safer therapies against different viral targets. Virion i...
Published: 1/27/2010   |   Inventor(s): David Kabat, Mariana Marin, Susan Kozak, Kristine Rose
Keywords(s): Research Tools - Screening, Therapeutics - Infectious Diseases
Category(s): Therapeutics
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