Search Results - therapeutics - infectious diseases

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siRNA sequence and method for treating dengue virus infection
siRNA sequence and method for treating dengue virus infection OHSU Technology 1601 Value Proposition: Dengue virus (DENV) is a leading cause of illness in the tropics and subtropics, with as many as 100 million people infected yearly. Currently, there is no approved vaccine for DENV or any approved antiviral compositions to treat DENV either...
Published: 9/16/2020   |   Inventor(s): David Stein, Klaus Frueh, Stuart Perry, Sujan Shresta
Keywords(s): Research Tools - Reagents, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Research Tools
Antiviral Drug Discovery for AIDS: The HIV-1 Vif Protein
Technology OverviewDespite remarkable medical advances, the incidence of HIV infections continues to rise throughout the world. The majority of current HIV therapies target HIV reverse transcriptase or protease, but viral resistance and toxicity have created a need for more potent and safer therapies against different viral targets. Virion infectivity...
Published: 9/16/2020   |   Inventor(s): David Kabat, Mariana Marin, Susan Kozak, Kristine Rose
Keywords(s): Research Tools - Screening, Therapeutics - Infectious Diseases
Category(s): Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Small molecule activates innate immune responses controlled by the human protein STING.
Researchers at OHSU have discovered a novel small molecule agonist of human protein STING that may be administered either as an adjuvant to a vaccine or as independent therapy for treatment of infectious disease and/or cancer.
Published: 6/30/2020   |   Inventor(s): Victor DeFilippis, Jinu Abraham, Sara Botto
Keywords(s): Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Vaccines, Therapeutics
Compounds for treating parasitic disease.
Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of compounds that are superior to the standard of care. The antimalarial agents are effective at inhibiting proliferation of multi-drug resistant malarial parasites and selected members of this potent class are...
Published: 9/24/2014   |   Inventor(s): Michael Riscoe, Rolf Winter, David Hinrichs
Keywords(s): Diagnostics, Diagnostics - Infectious Disease, Therapeutics, Therapeutics - Infectious Diseases
Category(s): Chemical, Therapeutics
Cloroquine Replacement Drugs
Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of compounds that are superior to the standard of care. The antimalarial agents are effective at inhibiting proliferation of multi-drug resistant malarial parasites and selected members of this potent class are...
Published: 11/5/2012   |   Inventor(s): Michael Riscoe, Rolf Winter, Sovitj Pou, David Hinrichs, Jane Kelly, Yuexin Li, Aaron Nilsen
Keywords(s): Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Chemical
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