Search Results - brian druker

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Novel activating NTRK2 and NTRK3 mutations as biomarkers for NTRK inhibitor sensitivity in cancer
Neurotrophic receptor tyrosine kinases (NTRK) are a family of genes involved in neuronal development. Mutations in these proteins result in dysregulation of neurons and may increase the risk of disease. NTRK gene fusions have previously been implicated as oncogenic drivers in various solid tumors. Researchers at OHSU have now identified four novel ...
Published: 7/3/2017   |   Inventor(s): Cristina Tognon, Monika Davare, Kristin Qian, Brian Druker
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Oncogenic CSF3R Mutations in Neutrophilic Leukemia
Atypical chronic myelogenous leukemia (aCML) and chronic neutrophilic leukemia (CNL) are rare blood cancers with poor prognoses and no standard of care exists for these disorders. Patients are typically diagnosed using histological and cytogenetic techniques and few recurrent genetic mutations are associated with these disorders. OHSU investigato...
Published: 6/15/2017   |   Inventor(s): Jeffrey Tyner, Julia Maxson, Brian Druker
Keywords(s): Diagnostics - Cancer
Category(s): Diagnostics
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