Search Results - therapeutics+-+immunology

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Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
SummaryResearchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel PARP...
Published: 8/7/2020   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Small molecule activates innate immune responses controlled by the human protein STING.
SummaryStimulator of IFN genes (STING) is a signaling molecule that activates immune responses and STING-mediated phenotypes have been shown to enhance both vaccine-associated protection and immune-based antitumor therapies. Oregon Health & Science University researchers have developed a novel small molecule activating ligand of STING, which may...
Published: 6/30/2020   |   Inventor(s): Victor DeFilippis, Jinu Abraham, Sara Botto
Keywords(s): Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Vaccines, Therapeutics
Compounds that bind macrophage migration inhibitory factor
Technology Summary:Recombinant polypeptide composition for treatment of progressive multiple sclerosis (MS). This peptide approach selectively blocks key pro-inflammatory factors that could stop MS progression. Derived from CD74, the new composition competes for binding of the CD74 ligand, macrophage migration inhibitory factor (MIF). CD74 is a chaperone...
Published: 3/1/2016   |   Inventor(s): Arthur Vandenbark, Gil Benedek, Roberto Meza-Romero
Keywords(s): Therapeutics, Therapeutics - Immunology
Category(s): Therapeutics
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