Search Results - paolo+bernardi

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Compositions for treatment of neurological and oxidative stress disorders
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 6/22/2021   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
CyP-D Knock-Out Mice
Technology OverviewCyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies. These animals and their cells...
Published: 9/16/2020   |   Inventor(s): Michael Forte, Paolo Bernardi, Emy Basso
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Small Molecule Inhibitors of the Mitochondrial Permeability Transition Pore (PTP)
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 2/2/2015   |   Inventor(s): Michael Forte, Dennis Bourdette, Paolo Bernardi, Justina Sileikyte, Frank Schoenen, Sudeshna Roy
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
Mouse lines for the conditional elimination of the expression of the peripheral benzodiazapine receptor
Technology OverviewThe peripheral benzodiazepine receptor (PBR) is an 18 kDa, highly hydrophobic protein located in the outer mitochondrial membrane that was initially identified as a binding site for benzodiazepines in tissues that lack GABA receptors, the clinical target of benzodiazepines in the central nervous system. Mouse lines have been generated...
Published: 1/27/2010   |   Inventor(s): Michael Forte, Elizabeth Blachly-Dyson, Paolo Bernardi
Keywords(s): Biological Materials, Biological Materials - Mice
Category(s): Biological Materials
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