Search Results - research+tools+-+screening

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Human cytomegalovirus (HCMV) clinical isolate strain: Gerry
Technology Overview Dr. Jay Nelson has a collection of HCMV strains available for licensing as a package or on an individual strain basis. The full list of strains which are available are listed under OHSU Technology #1221. These are all clinical isolates that are at early passage and have not been adapted to any cell type and should therefore...
Published: 9/16/2020   |   Inventor(s): Jay Nelson
Keywords(s): Biological Materials, Biological Materials - Other, Research Tools, Research Tools - Reagents, Research Tools - Screening
Category(s): Biological Materials, Research Tools
Human cytomegalovirus (HCMV) clinical isolate strain: Edding
Technology Overview Dr. Jay Nelson has a collection of HCMV strains available for licensing as a package or on an individual strain basis. The full list of strains which are available are listed under OHSU Technology #1221. These are all clinical isolates that are at early passage and have not been adapted to any cell type and should therefore...
Published: 9/16/2020   |   Inventor(s): Jay Nelson
Keywords(s): Biological Materials, Biological Materials - Other, Research Tools, Research Tools - Reagents, Research Tools - Screening
Category(s): Biological Materials, Research Tools
Human cytomegalovirus (HCMV) clinical isolate strain: Dement
Technology Overview Dr. Jay Nelson has a collection of HCMV strains available for licensing as a package or on an individual strain basis. The full list of strains which are available are listed under OHSU Technology #1221. These are all clinical isolates that are at early passage and have not been adapted to any cell type and should therefore...
Published: 9/16/2020   |   Inventor(s): Jay Nelson
Keywords(s): Biological Materials, Biological Materials - Other, Research Tools, Research Tools - Reagents, Research Tools - Screening
Category(s): Biological Materials, Research Tools
Human cytomegalovirus (HCMV) clinical isolate strain: Davis
Technology Overview Dr. Jay Nelson has a collection of HCMV strains available for licensing as a package or on an individual strain basis. The full list of strains which are available are listed under OHSU Technology #1221. These are all clinical isolates that are at early passage and have not been adapted to any cell type and should therefore...
Published: 9/16/2020   |   Inventor(s): Jay Nelson
Keywords(s): Biological Materials, Biological Materials - Other, Research Tools, Research Tools - Reagents, Research Tools - Screening
Category(s): Biological Materials, Research Tools
Human cytomegalovirus (HCMV) clinical isolate strain: Brown
Technology Overview Dr. Jay Nelson has a collection of HCMV strains available for licensing as a package or on an individual strain basis. The full list of strains which are available are listed under OHSU Technology #1221. These are all clinical isolates that are at early passage and have not been adapted to any cell type and should therefore...
Published: 9/16/2020   |   Inventor(s): Jay Nelson
Keywords(s): Biological Materials, Biological Materials - Other, Research Tools, Research Tools - Reagents, Research Tools - Screening
Category(s): Biological Materials, Research Tools
A cellular model for human pantothenate kinase 2 dysfunction
Technology Overview Researchers at Oregon Health & Science University have developed the first and only cell based PKAN model whereby human fibroblasts with respiratory dysfunction are maintained and utilized to screen compounds for biological activity against PKAN cellular phenotypes associated with PANK2 gene mutations. Licensing Opportunity This...
Published: 9/29/2022   |   Inventor(s): Susan Hayflick, Suh Young Jeong
Keywords(s): Biological Materials - Cell Lines, Research Tools - Screening
Category(s): Research Tools
Sensor for Akt kinase activity in living cells
Technology Overview Researchers at Oregon Health & Science University have developed a novel Akt biosensor which provides a robust readout for the PI3-kinase signaling pathway in living cells without the use complex microscopy techniques. This biosensor allows quantitative tracking of Akt activity for days in individual cells within a population,...
Published: 9/23/2022   |   Inventor(s): Peter Rotwein, Sean Gross
Keywords(s): Research Tools - Reagents, Research Tools - Screening
Category(s): Research Tools
Novel biosensor for direct measurement of bioavailable NAD+
Summary This technology provides a unique cell-based platform for targeting NAD+-(nicotinamide adenine dinucleotide) regulatory pathways in the treatment of human diseases. An emerging theme in age-related pathologies—e.g. neurodegeneration, cancer, cardiovascular disease, inflammation, type 2 diabetes, and metabolic disease—is due to the...
Published: 9/23/2022   |   Inventor(s): Richard Goodman, Michael Cohen, Xiaolu (Lulu) Cambronne, Melissa Stewart
Keywords(s): Research Tools - Screening
Category(s): Research Tools
Split-luciferase complementation to measure soluble epoxide hydrolase dimerization
Technology Overview Soluble epoxide hydrolase (sEH) inhibition is a therapeutic target for a large number of cardiovascular diseases. Disrupting dimerization of sEH reduces hydrolase activity and shifts the sub-cellular localization of sEH to peroxisomes. The current technology is a split-firefly luciferase assay that not only measures disruption of...
Published: 10/20/2022   |   Inventor(s): Jonathan Nelson, Nabil Alkayed, Xiangshu Xiao
Keywords(s): Biological Materials, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT V654A + D816Y
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816Y cell line and drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retrovirus...
Published: 1/13/2016   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
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