Search Results - research tools - screening

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A cellular model for human pantothenate kinase 2 dysfunction
Researchers at Oregon Health & Science University have developed the first and only cell based PKAN model whereby human fibroblasts with respiratory dysfunction are maintained and utilized to screen compounds for biological activity against PKAN cellular phenotypes associated with PANK2 gene mutations. For licensing, please contact OHSU Technol...
Published: 7/5/2016   |   Inventor(s): Susan Hayflick, Suh Young Jeong
Keywords(s): Biological Materials - Cell Lines, Research Tools - Screening
Category(s): Research Tools
Sensor for Akt kinase activity in living cells
Researchers at Oregon Health & Science University have developed a novel Akt biosensor which provides a robust readout for the PI3-kinase signaling pathway in living cells without the use complex microscopy techniques. This biosensor allows quantitative tracking of Akt activity for days in individual cells within a population, and responds with...
Published: 10/8/2015   |   Inventor(s): Peter Rotwein, Sean Gross
Keywords(s): Research Tools - Reagents, Research Tools - Screening
Category(s): Research Tools
Novel Biosensor for Direct Measurement of Bioavailable NAD+
This technology provides a unique cell-based platform for targeting NAD+-(nicotinamide adenine dinucleotide) regulatory pathways in the treatment of human diseases. An emerging theme in age-related pathologies—e.g. neurodegeneration, cancer, cardiovascular disease, inflammation, type 2 diabetes, and metabolic disease—is due to the misre...
Published: 8/28/2015   |   Inventor(s): Richard Goodman, Michael Cohen, Xiaolu (lulu) Cambronne, Melissa Stewart
Keywords(s): Research Tools - Screening
Category(s): Research Tools
Split-luciferase complementation to measure soluble epoxide hydrolase dimerization
Novel assay and technique to monitor the effect of mutations on dimerization. The enzyme soluble epoxide hydrolase (sEH) forms a catalytically active dimer with predominantly cytosolic localization. Disrupting dimerization, on the other hand, reduces sEH hydrolase activity and shifts the sub-cellular localization of sEH to peroxisomes. The per...
Published: 1/29/2015   |   Inventor(s): Jonathan Nelson, Nabil Alkayed, Xiangshu Xiao
Keywords(s): Biological Materials, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT V654A + D816Y
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816Y cell line and drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retroviru...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT V654A + D816F
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816F cell line and subsequent drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due ...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT D816F retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due to retrovirus recombination events: I571M and M903I. These secondary events do not appear to alter the kinase properties of ...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT D816Y retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retrovirus recombination events: N587S and deletion of amino acids 931-961. These secondary events do not appear to alter...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
M5gNeo human KIT D816V retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. No mutation of KIT except for D816V.
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
MC5-R Knockout mice
Technology # 0387-B OverviewMC5-R is responsive to all melanocortins at physiological levels except g-MSH. The melanocortin-5 receptor (MC5-R) is found in a wide range of tissues from skeletal muscle, to adipose tissues, brain, lung, adrenal and stomach. Provided by this invention is a mouse model with a disruption of the MC5-R gene with a severe ...
Published: 1/29/2015   |   Inventor(s): Roger Cone, Malcolm Low, Wenbiao Chen
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
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