Method for identifying Family-Member Specific Targets of Mono-PARPs

Case ID:
2162
Web Published:
8/29/2016
Description:

Poly-(ADP-ribose) polymerases (PARPs) are emerging as critical regulators of cell function in both normal physiology and disease, particularly neurodegeneration and cancer. These enzymes transfer the ADP-ribose moiety from its substrate, nicotinamide adenine dinucleotide (NAD+), to amino acids of target proteins. Mono-PARPs, also known as mono-ADP-rybosyltransferases (mono-ARTDs), catalyze the transfer of a single unit of ADP-ribose from NAD+ to target proteins. The cellular functions of mono-ADP-ribosylation are not nearly as well understood as they are for poly-ADP-ribosylation, which is due in part to the lack of available chemical tools to study mono-PARPs. Researchers at Oregon Health & Science University have developed a strategy to identify direct protein targets of specific mono-PARPs. This novel method is expected to significantly advance our understanding of the cellular functions of mono-PARPs.

 

 

Cohen, Michael S. et. al. Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targets. J. Am. Chem. Soc. 2014; 136:5201-5204.

Patent Information:
For Information, Contact:
Travis Cook
Senior Technology Development Manager
Oregon Health & Science University
cooktr@ohsu.edu
Inventors:
Michael Cohen
Ian Carter-O'Connell
Rory Morgan
Haihong Jin
Keywords:
Diagnostics - Platforms
Research Tools
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