Search Results - michael+forte

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Compositions for treatment of neurological and oxidative stress disorders
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 6/22/2021   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
Yeast strain expressing human VDAC2
Technology OverviewThe voltage dependent anion channel (VDAC) proteins are the major pathways for metabolite flux through the outer membrane. These mitochondrial membrane proteins control the flux of anions through voltage gated mechanisms. VDACs have been shown to be important in apoptotic responses and linked to certain neurodegenerative diseases....
Published: 9/16/2020   |   Inventor(s): Michael Forte, Elizabeth Blachly-Dyson
Keywords(s): Biological Materials, Biological Materials - Other, Biological Materials - Receptors/Targets, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Yeast strain expressing human VDAC1
Technology OverviewThe voltage dependent anion channel (VDAC) proteins are the major pathways for metabolite flux through the outer membrane. These mitochondrial membrane proteins control the flux of anions through voltage gated mechanisms. VDACs have been shown to be important in apoptotic responses and linked to certain neurodegenerative diseases....
Published: 9/16/2020   |   Inventor(s): Michael Forte, Elizabeth Blachly-Dyson
Keywords(s): Biological Materials, Biological Materials - Other, Biological Materials - Receptors/Targets, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Yeast expressing human VDAC isoforms
Technology OverviewThe voltage dependent anion channel (VDAC) proteins are the major pathways for metabolite flux through the outer membrane. These mitochondrial membrane proteins control the flux of anions through voltage gated mechanisms. VDACs have been shown to be important in apoptotic responses and linked to certain neurodegenerative diseases....
Published: 9/16/2020   |   Inventor(s): Michael Forte, Elizabeth Blachly-Dyson
Keywords(s): Biological Materials, Biological Materials - Protein/Peptides, Biological Materials - Receptors/Targets
Category(s): Biological Materials
CyP-D Knock-Out Mice
Technology OverviewCyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies. These animals and their cells...
Published: 9/16/2020   |   Inventor(s): Michael Forte, Paolo Bernardi, Emy Basso
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Mammalian cell lines expressing stably transfected somatostatin receptor SSTR1
Technology Overview Technology 0355-A describes somatostatin which exerts multiple effects throughout the body by binding to specific somatostatin receptors. Two classes of somatostatin receptors (SRIF1 and SRIF2) had been distinguished biochemically and physiologically. cDNAs for two different rat somatostatin receptors have been characterized,...
Published: 9/16/2020   |   Inventor(s): Philip Stork, Michael Forte
Keywords(s): Biological Materials, Biological Materials - Cell Lines
Category(s): Biological Materials
Small Molecule Inhibitors of the Mitochondrial Permeability Transition Pore (PTP)
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 2/2/2015   |   Inventor(s): Michael Forte, Dennis Bourdette, Paolo Bernardi, Justina Sileikyte, Frank Schoenen, Sudeshna Roy
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
Mouse lines for the conditional elimination of the expression of the peripheral benzodiazapine receptor
Technology OverviewThe peripheral benzodiazepine receptor (PBR) is an 18 kDa, highly hydrophobic protein located in the outer mitochondrial membrane that was initially identified as a binding site for benzodiazepines in tissues that lack GABA receptors, the clinical target of benzodiazepines in the central nervous system. Mouse lines have been generated...
Published: 1/27/2010   |   Inventor(s): Michael Forte, Elizabeth Blachly-Dyson, Paolo Bernardi
Keywords(s): Biological Materials, Biological Materials - Mice
Category(s): Biological Materials
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