High-throughput precision medicine screening for solid tumors

Case ID:
2584
Web Published:
12/2/2022
Description:

Summary

The current technology provides a unique ex vivo biopsy culture method for improved and personalized screening of multiple drug combinations for solid tumors.

Technology Overview

Precision medicine allows for cancer therapies to be tailored to individual tumor characteristics, but current screening methods often lack the capacity to 1) capture the full tumor microenvironment and/or 2) allow for the testing of multiple drugs and drug combinations. The current technology provides a novel method for precision medicine screening of solid tumors to better predict effective tumor therapies and improve patient care. 

Features of the method include:

  • Tumor biopsy based ex vivo culture system that maintains the individual tumor microenvironment and immune signaling to better predict individual tumor responsiveness.
  • Implantation of a drug-delivery device within the biopsy culture that allows for the administration of multiple drugs and/or drug combination therapies to increase screening efficiency.
  • Post-drug delivery analysis of gene and protein expression for validation of tumor responsiveness.
  • Proof-of-concept validation studies in a mouse model of breast cancer.

Publication

Tatarova, Z. et al. “A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.” Nat Biotechnol (2022). Link

Licensing Opportunity

This technology is available for licensing.

Patent Information:
Category(s):
Diagnostics
For Information, Contact:
Anne Carlson
Assoc Dir, Tech Dev & Licensing
Oregon Health & Science University
503-494-7809
carlsann@ohsu.edu
Inventors:
Joe Gray
Zuzana Tatarova
Oliver Jonas
Keywords:
Diagnostics
Diagnostics - Cancer
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