Search Results - Research+Tools

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Cell-permeant and water-soluble rhodamine dyes for quantitative imaging applications
SummaryRhodamines are a class of fluorescent proteins (FP) that stand out for their higher photostability and brightness as well as easier synthesis compared to other FPs; however, classic rhodamines generally have poor water solubility and tend to aggregate in an aqueous environment. Oregon Health & Science University researchers have developed...
Published: 10/27/2021   |   Inventor(s): Summer Dowell (Gibbs), Lei Wang, Antonio Montano
Keywords(s): Imaging, Imaging - Other, Research Tools, Research Tools - Reagents
Category(s): Imaging, Research Tools
Improved detection of heart-rate variability for wearable devices
Summary Heart-rate variability (HRV) is a suggested marker of the autonomic nervous system, but artifacts produced by movement with wrist worn devices decreases the validity and utility of this data. Oregon Health & Science University researchers have developed an improved method of removing motion artifacts, understanding the amount of data that...
Published: 10/4/2021   |   Inventor(s): David Sheridan, Steven Baker, Ryan Dehart
Keywords(s): Diagnostics, Research Tools, Software
Category(s): Diagnostics, Research Tools, Software
RadSearch: a radiology report search engine
Summary Harnessing the power of large databases is contingent upon the ability to access datapoints efficiently and accurately; however, this has proven difficult in the field of radiology where complex visual and written records must be integrated. Oregon Health & Science University research has led to the development of a novel radiology-specific...
Published: 9/23/2021   |   Inventor(s): Ningcheng (Peter) Li
Keywords(s): Research Tools, Software
Category(s): Software, Research Tools
Audio/visual information from semi-structured conversations paired with cognitive clinical data
SummaryA rare dataset containing high quality audio and visual information from semi-structured videocall conversations that is paired with cognitive clinical data and weekly surveys assessing social engagement and psychological well-being.Technology OverviewVideocall formats offer the opportunity to easily record visual and audio information to assess...
Published: 8/20/2021   |   Inventor(s): Hiroko Dodge
Keywords(s): Research Tools
Category(s): Multimedia, Research Tools, Speech & Language
New method of targeted sequencing using CRISPR-Cas12a-mediated capture of nucleic acids
SummaryOregon Health & Science University researchers have developed an improved method of targeted sequencing that is inexpensive, scalable and could be utilized to create custom sequencing panels for genetic testing.Technology OverviewNumerous methods for targeted sequencing have been developed but each have their own limitations. PCR-based approaches...
Published: 7/22/2021   |   Inventor(s): Brian O'Roak, Andrew Adey, Taylor Mighell, Ryan Mulqueen, Casey Thornton
Keywords(s): Diagnostics - Platforms, Next Generation Sequencing, Research Tools
Category(s): Research Tools
Subtyping Autism Using a Novel Machine Learning Method
Summary Autism spectrum disorder (ASD) is a heterogenous disease, making it difficult to develop diagnostic measures and effective treatments. Oregon Health and Science University researchers have developed a novel AI method for identifying ASD subgroups, which could help refine ASD diagnostic criteria and further the study of precision medicine for...
Published: 7/6/2021   |   Inventor(s): Eric Feczko, Damien Fair, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Neurology, Diagnostics - Other, Research Tools, Software - Diagnostic/Detection
Category(s): Diagnostics, Research Tools, Software
Versatile Interacting Peptide Tags for High Resolution Microscopy
SummaryResearchers at OHSU have developed a novel system for tracking multiple cellular proteins using genetically encoded peptide tags, which are smaller than antibodies and demonstrate greater labeling efficiency, expanding the capabilities of existing imaging and microscopy techniques. Technology OverviewProtein labeling methods often rely on large,...
Published: 6/8/2021   |   Inventor(s): Kimberly Beatty, Hannah Zane, Julia Doh
Keywords(s): Research Tools
Category(s): Research Tools
secreTRAP: a system for monitoring and quantifying protein secretion from single cells
SummaryCurrent research methods for measuring protein release rely on quantifying bulk levels in serum and lack the ability to determine temporal and cell-specific release patterns. Oregon Health & Science University researchers have developed a novel technique to allow for visualization and quantification of protein and peptide release in real-time...
Published: 5/11/2021   |   Inventor(s): Julia Huey, Carsten Schultz
Keywords(s): Research Tools, Research Tools - Other
Category(s): Research Tools
Tomographic bright field imaging (TBFI)
SummaryTomographic bright field image analysis enables the three-dimensional measurement of engineered and biological specimens without the requirement of sample labeling or expensive specialized optical equipment. This novel software offers the unique advantage of true quantitative image analysis of factors like mass and density and could provide a...
Published: 4/27/2021   |   Inventor(s): Owen McCarty, Kevin Phillips, Steven Jacques
Keywords(s): Imaging, Imaging - Other, Research Tools, Research Tools - Other, Software, Software - Other
Category(s): Imaging, Software, Research Tools
Rat monoclonal antibody to pS62-MYC
Summary MYC is a proto-oncogene associated with tumor pathogenesis in multiple cancer types, but currently there is a lack of reliable antibodies to assess MYC levels in FFPE patient samples. OHSU researchers have developed a rat monoclonal Serine 62 phosphorylated MYC antibody, which recognizes a form of MYC associated with increased protein stability...
Published: 4/13/2021   |   Inventor(s): Rosalie Sears, Colin Daniel
Keywords(s): Biological Materials, Biological Materials - Antibodies, Diagnostics - Cancer, Research Tools
Category(s): Biological Materials, Research Tools
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