Compounds that bind macrophage migration inhibitory factor

Case ID:
2165
Web Published:
3/1/2016
Description:

Compositions for recombinant polypeptides derived from CD74, a chaperone that assists with the folding and trafficking of Class II MHC (Major Histocompatibility Complex), that compete for binding of the CD74 ligand macrophage migration inhibitory factor (MIF). Possible use as a therapeutic to block inflammation driven by MIF interactions with CD 74. Used as an alternative to a MIF specific mAb as it is more selective in its ability to block MIF signaling through CD74.

Patent Information:
Category(s):
Therapeutics
For Information, Contact:
Michele Gunness
Senior Technology Development Manager
Oregon Health & Science University
(503) 494-8200
gunnessm@ohsu.edu
Inventors:
Arthur Vandenbark
Gil Benedek
Roberto Meza-Romero
Keywords:
Therapeutics
Therapeutics - Immunology
© 2018. All Rights Reserved. Powered by Inteum