Search Results - Therapeutics

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Methods of treating venetoclax-resistant acute myeloid leukemia
SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher Eide, Ravindra Majeti
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
Mutation-Specific Treatment Strategies for Acute Myeloid Leukemia
Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...
Published: 11/12/2021   |   Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney
Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics, Diagnostics
Anti-cancer Compounds with Improved Cardiac Safety and Drug Resistance Profiles
SummaryTyrosine kinase inhibitors are effective targeted anti-cancer therapeutics, but currently available inhibitors have limitations due to drug resistance and cardiotoxic effects. Oregon Health & Science University researchers have developed a class of kinase inhibitors with an improved cardiovascular safety profile and the potential to overcome...
Published: 9/7/2021   |   Inventor(s): Sanjay Malhotra, Mallesh Pandrala, Dhanir Tailor, Mark Mercola, Arne Antoon Bruyneel
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
A first in class small molecule as a novel YB1 inhibitor.
SummaryThe development of resistance to chemotherapy treatment in solid tumors is associated with up-regulation of the DNA/RNA binding protein Y box binding protein 1 (YB-1) and a worsened prognosis for cancer patients. Oregon Health & Science University researchers have developed a first-in-class small molecule inhibitor of YB-1 that synergizes...
Published: 9/7/2021   |   Inventor(s): Sanjay Malhotra, Dhanir Tailor
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
Oncofertility Vitrification Kit
SummaryCancer therapies have the unwanted side-effect of damaging ovarian tissue and prepubertal girls must have ovarian tissue cryopreserved to preserve their fertility. Oregon Health & Science University (OHSU) researchers have developed a simple-to-use and inexpensive vitrification kit for better preservation of ovarian tissue, which allows for...
Published: 7/8/2021   |   Inventor(s): Mary Zelinski, Alison Ting, Steven Mullen, Gregory Fahy, Teresa Woodruff, Monica Laronda
Keywords(s): Specimen Collection and Preservation
Category(s): Therapeutics
Compositions for treatment of neurological and oxidative stress disorders
SummaryDysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 6/22/2021   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
A photocrosslinkable bone derived biomaterial for tissue engineering applications
Summary Demineralized bone matrix has been widely used in the clinic to heal bone injuries due to its remarkable regenerative properties. However, this is not a material that can be synthesized in large batches, with highly reproducible chemistry, and cannot be set/polymerized in-situ for precise adaptation. BoneMA is photopolymerizable material that...
Published: 3/31/2021   |   Inventor(s): Luiz Bertassoni, Avathamsa Athirasala
Keywords(s):  
Category(s): Therapeutics, Device
3D printed modular and scalable scaffolds for regenerative medicine
Summary Current bone scaffold options are limited in their ability to control and guide host-tissue ingrowth. OHSU researcher Dr. Luiz Bertassoni has designed a 3-D printed modular bone scaffold system, which funcitons as an array of microcages that can be loaded with the delivery factor of choice, and be easily stacked like LEGO blocks to adapt to...
Published: 3/31/2021   |   Inventor(s): Luiz Bertassoni, Avathamsa Athirasala, Anthony Tahayeri
Keywords(s): Device
Category(s): Therapeutics
Nanoparticle ultrasound contrast agents with high acoustic activity
SummaryContrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 2/24/2021   |   Inventor(s): Adem Yildirim, Jose Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
Novel albumin binder for improving the targeting efficacy of diagnostic or therapeutic reagents
Technology Summary Albumin binders have been developed to improve tumor uptake of therapeutic radioisotopes (radiopeptides) by prolonging radiopeptide blood circulation. However, use of these albumin binders also results in an increased uptake of radiopeptide in healthy organs, negating the benefits of the treatment. Researchers at Oregon Health...
Published: 1/28/2021   |   Inventor(s): Dexing Zeng, Lingyi Sun, Zhonghan Li
Keywords(s): Diagnostics - Cancer, Imaging, Therapeutics - Cancer
Category(s): Therapeutics, Chemical, Imaging
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