Search Results - Therapeutics

72 Results

Sort By:

Next-Generation ROS Nanotherapy for Targeted Cancer Destruction

Produces complementary reactive oxygen species in tumors, enabling efficient tumor killing without external activation Background Conventional cancer treatments such as surgery, chemotherapy, and radiotherapy are often invasive, non-specific, and associated with systemic toxicity and long-term side effects. Emerging nanomedicine approaches improve...

Published: 5/8/2026 | Updated: 5/8/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Chao Wang

Keywords(s): breast cancer, chemodynamic therapy (CDT), Fenton reaction, ferrous, immuno-oncology, metal-organic framework (MOF), nanomedicine, oncology therapeutics, porphyrin, reactive oxygen species (ROS), Russell mechanism, solid tumor, tumor microenvironment, tumor suppression, tumor targeting, tumour microenvironment

Category(s): Therapeutics

Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia

Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo

Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance

Category(s): Therapeutics

Next-Generation Photothermal Nanoagent for Safe Systemic Tumor Ablation

A resonance energy transfer (RET)–engineered nanoplatform enabling complete tumor ablation using near-infrared irradiation Background Photothermal therapy (PTT) uses NIR light to generate localized tumor heating. However, many systems require elevated laser power densities to achieve therapeutic temperatures, limiting translational feasibility....

Published: 4/3/2026 | Updated: 4/3/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Prem Singh

Keywords(s):

Category(s): Therapeutics, Medical Devices

Malassezia-Secreted Factor with Antibiotic Activity

1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...

Published: 1/8/2026 | Updated: 1/2/2026 | Inventor(s): Matthew Barber, Caitlin Kowalski

Keywords(s):

Category(s): Therapeutics, Diagnostics, Research Tools

Moderate-Affinity Affibodies for Controlled Protein Delivery and Bioactivity

1. Technology Overview The invention introduces a novel method for controlled protein delivery and bioactivity using moderate-affinity affibodies. These 58-amino acid peptides can specifically bind to various proteins, allowing for the controlled release or sequestration of multiple payloads within a single vehicle. The technology leverages the conjugation...

Published: 1/8/2026 | Updated: 1/2/2026 | Inventor(s): Marian Hettiaratchi, Henry Hochstatter, Veronica Spaulding, Jonathan Dorogin, Alycia Galindo, Chandler Asnes, Madeline Martin, Justin Svendsen

Keywords(s):

Category(s): Medical Devices, Therapeutics, Materials Science

Anisotropic Poly(ethylene glycol)-Based Hydrogels Synthesized via Two-Stage Polymerization and Mechanical Alignment

1. Technology Overview The invention introduces synthetic poly(ethylene glycol)-based hydrogels with anisotropic polymer network topology, mimicking the structure of musculoskeletal tissues. These hydrogels are synthesized using a two-stage polymerization process, allowing for the application of mechanical force to impart anisotropy. The technology...

Published: 1/2/2026 | Updated: 1/2/2026 | Inventor(s): Danielle Benoit, Tayler Hebner

Keywords(s):

Category(s): Chemistry, Therapeutics

A photocrosslinkable bone derived biomaterial for tissue engineering applications

Summary Demineralized bone matrix has been widely used in the clinic to heal bone injuries due to its remarkable regenerative properties. However, this is not a material that can be synthesized in large batches, with highly reproducible chemistry, and cannot be set/polymerized in-situ for precise adaptation. BoneMA is photopolymerizable material that...

Published: 7/23/2025 | Updated: 7/23/2025 | Inventor(s): Luiz Bertassoni, Avathamsa Athirasala

Keywords(s):

Category(s): Therapeutics, Device

Phage Bank for Selection of Personalized Therapeutic Treatments against Mycobacteria

A phage bank comprising lytic phages against mycobacteria, used to create phage cocktails for treatment of drug-resistant infections Background Non‑tuberculous mycobacteria (NTM) pathogens are extremely antibiotic resistant causing the most difficult-to-treat pulmonary infections in immunocompromised individuals such are cystic fibrosis (CF), bronchiectasis,...

Published: 8/4/2025 | Updated: 1/17/2025 | Inventor(s): Lia Danelishvili

Keywords(s):

Category(s): Biological Materials, Therapeutics

Selective Modulators of Ah-R to Treat Cancer

Synergistic compositions and method of using modulators of Ah-R activity and synergistic compounds to treat cancer Background Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. When activated by the binding of a wide range of both endogenous and exogenous small molecules, AhR signaling influences cellular outcomes in different...

Published: 8/4/2025 | Updated: 1/8/2025 | Inventor(s): Siva Kolluri, Bach Nguyen, Daniel Elson

Keywords(s):

Category(s): Therapeutics

Malaria transmission blocking using ELQ-infused bed nets

Summary Insecticide-treated mosquito bed nets reduce the transmission of malaria, but mosquitos have developed resistance to insecticides leading to reduced efficacy. Our new technology is a chemical solution for mosquito nets that kills malaria, is less prone to drug-resistance and is not toxic to humans. Technology Overview Insecticide-treated...

Published: 5/1/2026 | Updated: 10/15/2024 | Inventor(s): Michael Riscoe, Aaron Nilsen, Joseph (Stone) Doggett, Flaminia Catteruccia, Douglas (Doug) Paton

Keywords(s): Therapeutics, Therapeutics - Infectious Diseases, Therapeutics - Other

Category(s): Therapeutics, Device, Chemical

1 2 3 4 5 6 7 8