Search Results - luiz+bertassoni

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eDentin- a tissue engineered reparative dentin

Summary Current dental restoration materials trigger immune responses and poorly replicate the natural structure of the tooth, which delays the healing process. The current technology is a novel biomaterial that more closely mimics natural dentin and thereby allows for more efficient healing of the tooth. Technology Overview Cement-based materials...

Published: 2/15/2024 | Inventor(s): Luiz Bertassoni, Cristiane Miranda Franca

Keywords(s): Dental, Device, Device - Other

Category(s): Dental, Device

A method to regenerate vascularized dental pulp for root canal dental therapy

Summary Current root canal therapies rely on removing necrotic tissue and filling the area with inert material, reducing vascularity in the dental pulp and overall health in the remaining tooth. The laboratory of Dr. Luiz Bertassoni has developed a novel root canal treatment that features a hydrogel filling with a hollow central chamber, which can...

Published: 1/15/2024 | Inventor(s): Luiz Bertassoni, Anthony Tahayeri, Avathamsa Athirasala, Jack Ferracane

Keywords(s):

Category(s): Dental

A photocrosslinkable bone derived biomaterial for tissue engineering applications

Summary Demineralized bone matrix has been widely used in the clinic to heal bone injuries due to its remarkable regenerative properties. However, this is not a material that can be synthesized in large batches, with highly reproducible chemistry, and cannot be set/polymerized in-situ for precise adaptation. BoneMA is photopolymerizable material that...

Published: 9/21/2023 | Inventor(s): Luiz Bertassoni, Avathamsa Athirasala

Keywords(s):

Category(s): Therapeutics, Device

"Tooth on a chip"- A microfluidic device to test interactions of biomaterials with dental structures

Summary The development of novel dental biomaterials requires in vitro validation and cytotoxicity studies; however, research platforms that accurately emulate the oral environment, the interface between biomaterials with the tooth, and the underlying dental pulp, do not currently exist. This is traditionally done by exposing plated cells to eluents...

Published: 2/21/2023 | Inventor(s): Luiz Bertassoni

Keywords(s): Dental, Device, Research Tools - Other

Category(s): Device

Modular scaffolds for regenerative medicine

Summary Current bone scaffold options are limited in their ability to control and guide host-tissue ingrowth. OHSU researcher Dr. Luiz Bertassoni has designed a 3-D printed modular bone scaffold system, which functions as an array of microcages that can be loaded with the delivery factor of choice, and be easily stacked like LEGO blocks to adapt to...

Published: 4/22/2024 | Inventor(s): Luiz Bertassoni, Avathamsa Athirasala, Anthony Tahayeri

Keywords(s): Device

Category(s): Therapeutics

A biomimetic mineralizing cell-culture medium

Summary A cell culture medium to control mineralization of extracellular matrix (hydrogels) in 2D and 3D cell cultures in regeneration studies. It allows the organic scaffold or matrix to mineralize over a set period of time in the presence of cells resulting in a structure that is similar to natural mineralized tissue. Technology Overview Bones...

Published: 9/30/2022 | Inventor(s): Luiz Bertassoni

Keywords(s): Biological Materials, Research Tools

Category(s): Biological Materials, Research Tools