Search Results - xiangshu xiao

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Split-luciferase complementation to measure soluble epoxide hydrolase dimerization
Novel assay and technique to monitor the effect of mutations on dimerization. The enzyme soluble epoxide hydrolase (sEH) forms a catalytically active dimer with predominantly cytosolic localization. Disrupting dimerization, on the other hand, reduces sEH hydrolase activity and shifts the sub-cellular localization of sEH to peroxisomes. The per...
Published: 1/29/2015   |   Inventor(s): Jonathan Nelson, Nabil Alkayed, Xiangshu Xiao
Keywords(s): Biological Materials, Research Tools - Screening
Category(s): Biological Materials, Research Tools
Novel Pyrroloquinazolines as Anti-cancer Agents
Novel and Effective Compounds for Triple Negative Breast Cancer Researchers at Oregon Health & Science University have discovered a novel lead compound that is active against triple negative breast cancer through what is believed to be a novel (unknown at this point-target identification underway) mechanism of action. The lead compound is ...
Published: 10/16/2013   |   Inventor(s): Xiangshu Xiao, Jingjin Chen, Bingbing Li
Keywords(s): Therapeutics - Cancer
Category(s): Therapeutics, Chemical
Pharmaceutical compositions comprising napthamides
Value Proposition: Researchers at Oregon Health & Science University discovered a novel compound that regulates transcription activity of CREB via a novel mechanism of action. Lead optimization resulted in a first in class chemical series that is potent and highly selective. The efficacy of these compounds has been validated in vitro (e.g....
Published: 10/16/2013   |   Inventor(s): Xiangshu Xiao
Keywords(s): Therapeutics - Cancer
Category(s): Chemical, Therapeutics
Naphthamides as anticancer agents inhibiting CREB-mediated gene transcription
Value Proposition: Researchers at Oregon Health & Science University discovered a novel compound that regulates transcription activity of CREB via a novel mechanism of action. Lead optimization resulted in a first in class chemical series that is potent and highly selective. The efficacy of these compounds has been validated in vitro (e.g....
Published: 5/1/2013   |   Inventor(s): Xiangshu Xiao, Bingbing Li
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Chemical, Therapeutics
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