Search Results - xiangshu+xiao

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Split-luciferase complementation to measure soluble epoxide hydrolase dimerization

Technology Overview Soluble epoxide hydrolase (sEH) inhibition is a therapeutic target for a large number of cardiovascular diseases. Disrupting dimerization of sEH reduces hydrolase activity and shifts the sub-cellular localization of sEH to peroxisomes. The current technology is a split-firefly luciferase assay that not only measures disruption of...

Published: 9/19/2023 | Inventor(s): Jonathan Nelson, Nabil Alkayed, Xiangshu Xiao

Keywords(s): Biological Materials, Research Tools - Screening

Category(s): Biological Materials, Research Tools

Pharmaceutical compositions comprising napthamides

SummaryResearchers at Oregon Health & Science University have developed a first-in-class chemical series that regulates transcription activity of CREB via a novel mechanism of action and has the potential to address an unmet medical need for treatment of multiple cancers. Technology OverviewTargeted therapies have demonstrated the ability to effectively...

Published: 11/21/2023 | Inventor(s): Xiangshu Xiao

Keywords(s): Therapeutics - Cancer

Category(s): Chemical, Therapeutics

Naphthamides as anticancer agents inhibiting CREB-mediated gene transcription

Summary Researchers at Oregon Health & Science University have developed a first-in-class chemical series that regulates transcription activity of CREB via a novel mechanism of action and has the potential to address an unmet medical need for treatment of multiple cancers. Technology Overview Targeted therapies have demonstrated the ability...

Published: 11/21/2023 | Inventor(s): Xiangshu Xiao, Bingbing Li

Keywords(s): Therapeutics, Therapeutics - Cancer

Category(s): Chemical, Therapeutics