Search Results - therapeutics - reproductive

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Method of Producing Human Pluripotent Stem Cells by Somatic Cell Nuclear Transfer
This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). PSC’s only naturally exist in early human embryos. Methods are described to produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin cells as a starting point. Human PSC’s...
Published: 8/5/2020   |   Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana
Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
CRISPR/Cas9-targeted correction of heterozygous mutations in human preimplantation embryos
More than 10,000 monogenic inherited disorders have been identified, affecting millions of people worldwide. Among these are the autosomal dominant mutations, where inheritance of a single copy of a defective gene can result in clinical symptoms. Dominant mutations that manifest as late-onset adult disorders include BRCA1 and BRCA2, associated with...
Published: 8/4/2017   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez
Keywords(s): Therapeutics - Reproductive
Category(s): Therapeutics
Methods to limit pathogenic mitochondrial DNA amplification in mitochondrial replacement therapy
Technology Overview Maternally inherited mitochondrial DNA (mtDNA) mutations, estimated to affect 778 newborns in US each year, result in mitochondrial dysfunction and may cause severe and life threatening disease with no effective treatment, such as Leigh Syndrome, MELAS or NARP. Therefore, mitochondrial replacement techniques have been developed to...
Published: 6/22/2017   |   Inventor(s): Dmitry Temiakov, Shoukhrat Mitalipov
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
A method to increase pregnancy rates for treatment of infertility
Technology OverviewBecause of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss, as well as birth defects are common. The main cause of this type of infertility, as several findings implicate, is the decline in oocyte quality associated to cytoplasmic deficiencies and mitochondrial dysfunction....
Published: 6/22/2017   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez, Dmitry Temiakov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
In vitro fertilization: Spindle transfer method for mitochondrial DNA replacement to circumvent genetically inherited genetic disorders
Technology OverviewMitochondria, cytoplasmic organelles containing their own DNA (mtDNA), are crucial for the cell as they supply the cell with the majority of energy needed for basic cellular functions. mtDNA is transmitted maternally and normally all its copies are identical within the cell unless mutations in mtDNA occur resulting in the co-existence...
Published: 6/22/2017   |   Inventor(s): Shoukhrat Mitalipov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Engineering, Biological Materials, Therapeutics
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