Search Results - therapeutics+-+reproductive

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Non-surgical permanent female contraception using a novel transcervical delivery device
Summary This catheter device is designed to provide clinicians with a simple, inexpensive office-based procedure for the assessment of tubal patency or delivery of a permanent contraceptive agent to the fallopian tubes. Technology Overview Currently, all methods of female permanent contraception require invasive surgery. This limits access to have...
Published: 10/3/2022   |   Inventor(s): Jeffrey Jensen, Ov Slayden, Jian Xin Guo, Philberta Leung
Keywords(s): Device, Device - Other, Therapeutics - Reproductive
Category(s): Device
Method of producing human pluripotent stem cells by somatic cell nuclear transfer
Summary This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). Technology Overview Pluripotent stem cells only naturally exist in early human embryos. The current methods produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin...
Published: 4/8/2024   |   Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana
Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
CRISPR/Cas9-targeted correction of heterozygous mutations in human preimplantation embryos
Technology Overview More than 10,000 monogenic inherited disorders have been identified, affecting millions of people worldwide. Among these are the autosomal dominant mutations, where inheritance of a single copy of a defective gene can result in clinical symptoms. Dominant mutations that manifest as late-onset adult disorders include BRCA1 and BRCA2,...
Published: 9/30/2022   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez
Keywords(s): Therapeutics - Reproductive
Category(s): Therapeutics
A method to increase pregnancy rates for treatment of infertility
Summary A method of generating functional human oocytes from polar bodies, which could be utilized to increase viable oocyte retrieval and prevent transmission of inherited mitochondrial DNA mutations. Technology Overview Because of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss,...
Published: 11/3/2022   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez, Dmitry Temiakov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
In vitro fertilization: Spindle transfer method for mitochondrial DNA replacement to circumvent genetically inherited genetic disorders
Summary The current technology is method of preventing mitochondrial DNA disease transmission through oocyte spindle transfer. Technology Overview Mitochondria, cytoplasmic organelles containing their own DNA (mtDNA), are crucial for the cell as they supply the cell with the majority of energy needed for basic cellular functions. mtDNA is transmitted...
Published: 9/21/2022   |   Inventor(s): Shoukhrat Mitalipov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Engineering, Biological Materials, Therapeutics
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