Method of Producing Human Pluripotent Stem Cells by Somatic Cell Nuclear Transfer

Case ID:
1838
Web Published:
8/5/2020
Description:

This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). PSC’s only naturally exist in early human embryos.  Methods are described to produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin cells as a starting point. Human PSC’s derived by SCNT are histocompatible to a patient who provide skin cells, while conventional embryonic stem cells (ESC’s) are isogenic. Furthermore, PSC’s derived by SCNT have the same advantages of embryo derived ESC’s since mitochondria and mitochondria DNA in skin cells are replaced by the oocyte’s material. This is a distinct advantage as currently available histocompatible induced pluripotent stem cells (iPS cells) contain aged or diseased mitochondria and mitochondria DNA from the patient’s cells. The OHSU method combines benefits, but excludes disadvantages of the other two existing pluripotent stem cell types.

Patent Information:
For Information, Contact:
Michele Gunness
Senior Technology Development Manager
Oregon Health & Science University
(503) 494-8200
gunnessm@ohsu.edu
Inventors:
Shoukhrat Mitalipov
Masahito Tachibana
Keywords:
Research Tools
Therapeutics
Therapeutics - Reproductive
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