Search Results - biological materials - cell lines

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Methods to limit pathogenic mitochondrial DNA amplification in mitochondrial replacement therapy
Technology Overview Maternally inherited mitochondrial DNA (mtDNA) mutations, estimated to affect 778 newborns in US each year, result in mitochondrial dysfunction and may cause severe and life threatening disease with no effective treatment, such as Leigh Syndrome, MELAS or NARP. Therefore, mitochondrial replacement techniques have been developed ...
Published: 6/22/2017   |   Inventor(s): Dmitry Temiakov, Shoukhrat Mitalipov
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
A method to increase pregnancy rates for treatment of infertility
Technology OverviewBecause of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss, as well as birth defects are common. The main cause of this type of infertility, as several findings implicate, is the decline in oocyte quality associated to cytoplasmic deficiencies and mitochondrial dys...
Published: 6/22/2017   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez, Dmitry Temiakov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics
In vitro fertilization: Spindle transfer method for mitochondrial DNA replacement to circumvent genetically inherited genetic disorders
Technology OverviewMitochondria, cytoplasmic organelles containing their own DNA (mtDNA), are crucial for the cell as they supply the cell with the majority of energy needed for basic cellular functions. mtDNA is transmitted maternally and normally all its copies are identical within the cell unless mutations in mtDNA occur resulting in the co-exis...
Published: 6/22/2017   |   Inventor(s): Shoukhrat Mitalipov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Engineering, Biological Materials, Therapeutics
ImmortaMAITs: immortalized Mucosal Associated Invariant T (MAIT) cells as new human cell line reagents for human immunobiology research
The Immorta-MAITs are human mucosal-associated invariant T (MAIT) cells. There are ten cell lines which are confirmed to express the MAIT T cell receptor alpha (TRAV1-2) and full TCR sequencing has been performed. The cell lines stain with an MR1-tetramer loaded with a MAIT antigen 5-OP-RU and not control MR1-tetramer loaded with 6FP. The Immort...
Published: 6/2/2017   |   Inventor(s): Erin Meermeier (riscoe), Irina Kurtz, David Lewinsohn, Marielle Gold
Keywords(s): Biological Materials - Cell Lines
Category(s): Biological Materials
A cellular model for human pantothenate kinase 2 dysfunction
Researchers at Oregon Health & Science University have developed the first and only cell based PKAN model whereby human fibroblasts with respiratory dysfunction are maintained and utilized to screen compounds for biological activity against PKAN cellular phenotypes associated with PANK2 gene mutations. For licensing, please contact OHSU Technol...
Published: 7/5/2016   |   Inventor(s): Susan Hayflick, Suh Young Jeong
Keywords(s): Biological Materials - Cell Lines, Research Tools - Screening
Category(s): Research Tools
Kidney cell lines for cytotoxicity research
Murine derived kidney cell lines (KPT11 and KPT3) useful for cytotoxicity research for nephrotoxicity and ototoxicity.Relevant Reference: Karasawa et al (2008) TRPV4 enhances the cellular uptake of aminoglycoside antibiotics. J. Cell Sci. 121 (17) 2871-2879.
Published: 12/1/2015   |   Inventor(s): Peter Steyger, Takatoshi Karasawa, Qi Wang
Keywords(s): Biological Materials - Cell Lines
Category(s): Biological Materials
pLXSN human KIT V654A + D816Y
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816Y cell line and drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retroviru...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT V654A + D816F
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816F cell line and subsequent drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due ...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT D816F retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due to retrovirus recombination events: I571M and M903I. These secondary events do not appear to alter the kinase properties of ...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT D816Y retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retrovirus recombination events: N587S and deletion of amino acids 931-961. These secondary events do not appear to alter...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
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