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Sunscreen Compounds and Formulations
Meadowfoam derived sunscreen compounds that reduce UVB-induced DNA damage Background Chronic skin exposure to solar ultraviolet radiation (UVR) leads to accumulated DNA damage resulting in skin aging and the possibility of cancer. To prevent this, sunscreens are formulated with additives that reflect or absorb UV wavelengths that are incident on...
Published: 2/26/2024   |   Inventor(s): Gitali Indra, Jan Frederik Stevens, Arup Indra, Evan Carpenter
Keywords(s):  
Category(s): Biological Materials, Chemical
eDentin- a tissue engineered reparative dentin
Summary Current dental restoration materials trigger immune responses and poorly replicate the natural structure of the tooth, which delays the healing process. The current technology is a novel biomaterial that more closely mimics natural dentin and thereby allows for more efficient healing of the tooth. Technology Overview Cement-based materials...
Published: 2/15/2024   |   Inventor(s): Luiz Bertassoni, Cristiane Miranda Franca
Keywords(s): Dental, Device, Device - Other
Category(s): Dental, Device
Artificial Intelligence-Assisted Projection-Resolved Optical Coherence Tomographic Angiography (aiPR-OCTA)
Summary The current artificial intelligence algorithm removes projection artifacts in optical coherence tomographic angiography images and improves the signal-to-noise ratio. Technology Overview A major limitation of optical coherence tomography angiography (OCTA) are image artifacts, particularly projection artifacts, which make the detection of...
Published: 2/2/2024   |   Inventor(s): Yali Jia, Jie Wang
Keywords(s): Imaging, Imaging - Other
Category(s): Imaging
A microcontroller for easier whole-cell patch clamping on dendrites and axons
Summary The current technology is a microcontroller that allows for the application of controlled negative pressure and simultaneous electrical impulses to make it easier to obtain whole-cell patch clamp recordings on small cellular structures. Technology Overview Whole-cell patch clamping is a technique commonly employed to study the electrical...
Published: 1/30/2024   |   Inventor(s): Stephen Smith, Timur Tsintsadze
Keywords(s): Research Tools, Research Tools - Other
Category(s): Research Tools
Covalent inhibitors of PARP-16 for cancer treatment
Summary The current technology is a selective, covalent inhibitor of PARP16 with potential therapeutic applications for the treatment of cancer. Technology Overview The poly-ADP-ribose-polymerase (PARP) family is made up of 17 enzymes in humans that are increasingly recognized as major downstream regulators of NAD+-mediated signaling in cells. PARP1...
Published: 2/12/2024   |   Inventor(s): Michael Cohen, Daniel Bejan, Sunil Sundalam
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
An OCT method to improve scleral lens fitting
Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...
Published: 1/5/2024   |   Inventor(s): David Huang, Yan Li, Clara Llorens Quintana
Keywords(s): Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Imaging, Software
CD74 as a biomarker and therapeutic target for familial platelet (FPD) disorder
Summary Research at OHSU has identified the CD74 signaling cascade as a potential therapeutic target and diagnostic biomarker for RUNX1-mutated familial platelet disorder (FPD), which is a premalignant condition for acute myeloid leukemia. Technology Overview Current estimates suggest as many as 18,000 people may be living with RUNX1-FPD in the United...
Published: 2/27/2024   |   Inventor(s): Anupriya Agarwal, Mona Mohammadhosseini
Keywords(s): Diagnostics, Diagnostics - Cancer, Diagnostics - Other, Therapeutics, Therapeutics - Cancer, Therapeutics - Other
Category(s): Diagnostics, Therapeutics
Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin
Technology Description To produce a library of S. fungicidicus mutants, an in vitro transposon-based method was devised to randomly insert a selectable marker and oriT element in fosmid inserts carrying segments of the enramycin biosynthetic gene cluster and adjacent regions. This library of mutagenized fosmids was screened to identify specific disrupted...
Published: 3/13/2024   |   Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银
Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals
Category(s): Therapeutics
Metamaterial Micro-LED Device
This LED uses a hybrid nanostructure to improve efficiency and intensity while avoiding costly transfer processes Background Recently, colloidal quantum dots (QDs) have appeared as promising emissive materials for micro-LEDs that can be used to form display panels without complicated transfer processes. Despite the remarkable luminescence properties...
Published: 3/19/2024   |   Inventor(s): Li-Jing Cheng
Keywords(s):  
Category(s): Engineering
Workplace Mental Health Support Training for Leaders - individual training seats
Summary The Workplace Mental Health Support Training for Leaders is a 1-hour online training designed by occupational health psychology scientists and has been scientifically demonstrated to provide valuable training for company leaders and improve employee feelings of wellness. Technology Overview Burnout, mental distress, and mental illnesses...
Published: 12/19/2023   |   Inventor(s): Leslie Hammer, Jennifer Dimoff
Keywords(s): Education & Training, Education & Training - Other
Category(s): Education & Training
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