A method to regenerate vascularized dental pulp for root canal dental therapy

Case ID:
2228
Web Published:
3/31/2021
Description:

Summary

Current root canal therapies rely on removing necrotic tissue and filling the area with inert material, reducing vascularity in the dental pulp and overall health in the remaining tooth.  The laboratory of Dr. Luiz Bertassoni has developed a novel root canal treatment that features a hydrogel filling with a hollow central chamber, which can be seeded with endothelial cells and potentially promote vascularization after root canal. 

 

Technology Overview

The biological function of the dental pulp is primarily regulated via the vasculature; therefore, novel root canal strategies that allow for regeneration of vascularized pulp are critically necessary. Work from the laboratory of Dr. Luiz Bertassoni has led to a novel strategy to produce pulp-like hydrogel tissue constructs that facilitate vascularization in full-length root canals. A conical shaped polysaccharide-based material is inserted into the canal, followed by hydrogel filling of the space and polymerization (see Figure).  The polysaccharide cast can then be removed or dissolved, leaving behind a channel that can be filled with endothelial cells to form a blood vessel like structure. Compared to other endodontic approaches, this technology offers a more simplified biofabrication strategy that is compatible with short-term vasculature formation offering improved clinical outcomes.

 

Publication

Athirasala, A., Lins, F., Tahayeri, A. et al. A Novel Strategy to Engineer Pre-Vascularized Full-Length Dental Pulp-like Tissue Constructs. Sci Rep 7, 3323 (2017).

 

Patent Information:
Category(s):
Dental
For Information, Contact:
Trina Voss
Technology Development Manager
Oregon Health & Science University
503-494-8200
vosst@ohsu.edu
Inventors:
Luiz Bertassoni
Keywords:
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