Search Results - chemistry

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Modulating Activity of Calcium Release Channels
Using a new assay for drug development (see Abrj-01), PSU researchers have developed new compounds that may prove useful in the treatment of heart arrhythmia. Ventricular arrhythmias appear to be caused by a calcium leak from the sarcoplasmic reticulum in cardiac muscle, and arrhythmias often lead to heart failure. Drugs that prevent and treat a...
Published: 7/23/2009   |   Inventor(s): Jonathan Abramson, Robert Strongin
Keywords(s): Chemistry, Therapeutics
Category(s): Therapeutics
Fluorophore-Tagged Cisplatin
Many types of cancer, including carcinomas, lymphomas, sarcomas, and others, are treated with the chemotherapy agent Cisplatin. Based on the element platinum, cisplatin causes apoptosis in cancer cells by cross-linking their DNA. Like many chemotherapy agents, Cisplatin's effectiveness could be improved by better understanding how the body moves ...
Published: 7/20/2009   |   Inventor(s): Robert Strongin, Martha Sibrian-Vazquez, Jorge Escobedo, Peter Streyger
Keywords(s): Biology, Chemistry, Drug Screening, Therapeutics
Category(s): Therapeutics
Solution-Based Synthesis of Functional Graphene
PSU researchers have developed techniques to covalently attach single and multiple layers of graphene sheets on substrates. The graphene can subsequently be functionalized for use in nanobiosensor applications. Procedures are being developed for the solution-based synthesis and functionalization of graphene sheets from graphite in a way that is str...
Published: 7/20/2009   |   Inventor(s): Mingdi Yan, Li Liu
Keywords(s): Chemistry, Nanotechnology
Category(s): Chemistry
Screen for Redox Activity of Compounds
The design of new and effective drugs is a multi-billion dollar business, requiring great expense and extensive testing of drug candidate compounds. Obtaining a better understanding of the pharmacodynamics and mechanisms of action of drug candidates is an important and necessary step in optimizing any lead compound. A property of increasin...
Published: 6/3/2009   |   Inventor(s): Jonathan Abramson, Benjamin Marinov, Rotimi Olojo
Keywords(s): Biology, Chemistry, Drug Screening
Category(s): Therapeutics
Cleaner, Less Expensive Amine Production
PSU researchers and their collaborators have uncovered and engineered a new class of enzymes - the nitrile oxido reductases - that can aid in the chemical production of amines. In today's society, chemical manufacturing industries are facing increasing demands to practice environmentally conscientious methods and processes. Like all businesses, ...
Published: 5/26/2009   |   Inventor(s): Dirk Iwata-Reuyl, Valerie De Crecy-Lagard, Steven Van Lanen
Keywords(s): Chemistry
Category(s): Chemistry
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