Search Results - ryan+mehl

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Inclusion Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)

Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...

Published: 2/19/2026 | Inventor(s): Richard Cooley, Cat Vesely, Ryan Mehl

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Category(s): Biological Materials

Multimeric Therapeutic Nanobodies

Background Assembling nanobodies (Nb) into polyvalent multimers is a powerful strategy for improving the effectiveness of Nb-based therapeutics and biotechnological tools. However, generally effective approaches to Nb assembly are currently restricted to the N- or C-termini, greatly limiting the diversity of Nb multimers that can be produced. Here,...

Published: 8/4/2025 | Inventor(s): Ryan Mehl, Elise Van Fossen, Riley Bednar

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Category(s): Nanoscience & Microtechnologies, Physical Science, Biological Materials

Genetic incorporation of tetrazine amino acids and use in bioorthogonal ligations

Technology Description Ideal bioorthogonal reactions containing high reaction rates, high selectivity and high stability would allow for stoichiometric labeling of biomolecules in minutes and eliminate the need to washout excess labeling reagent. Currently no general method exists for controlled stoichiometric or sub-stoichiometric labeling of proteins...

Published: 1/22/2026 | Inventor(s): Ryan Mehl, Robert Blizzard

Keywords(s): Biological & Environmental Engineering, Biomedical, Biotechnology, Diagnostic, Labels, Protein Polymer Hybrids, Research Tools

Category(s): Diagnostics