Search Results - ryan+mehl

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Background Assembling nanobodies (Nb) into polyvalent multimers is a powerful strategy for improving the effectiveness of Nb-based therapeutics and biotechnological tools. However, generally effective approaches to Nb assembly are currently restricted to the N- or C-termini, greatly limiting the diversity of Nb multimers that can be produced. Here,...

Published: 8/11/2023 | Inventor(s): Ryan Mehl, Elise Van Fossen, Riley Bednar

Keywords(s):

Category(s): Nanoscience & Microtechnologies, Physical Science, Biological Materials

Genetic incorporation of tetrazine amino acids and use in bioorthogonal ligations

Technology Description Ideal bioorthogonal reactions containing high reaction rates, high selectivity and high stability would allow for stoichiometric labeling of biomolecules in minutes and eliminate the need to washout excess labeling reagent. Currently no general method exists for controlled stoichiometric or sub-stoichiometric labeling of proteins...

Published: 3/19/2024 | Inventor(s): Ryan Mehl, Robert Blizzard

Keywords(s): Biological & Environmental Engineering, Biomedical, Biotechnology, Diagnostic, Labels, Protein Polymer Hybrids, Research Tools

Category(s): Diagnostics