Search Results - sudarshan anand

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MicroRNA inhibitors to enhance radiotherapy efficacy
Almost 50% of cancer patients undergo some form of radiotherapy; however only half of these patients have a significant response to this treatment. Higher doses of radiation can be effective, but often result in damage to nearby healthy organs. One approach to increase radiotherapy sensitivity of the targeted tissue is to enhance the efficacy of lower/normal...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Shushan Rana, Charles Thomas
Keywords(s): Diagnostics - Cancer, Therapeutics - Cancer
Category(s): Diagnostics, Therapeutics
RNA biomarkers for predicting radiotherapy effectiveness
The standard of care for patients with a diagnosis of colorectal cancer is radiation therapy to reduce tumor size, followed by surgery. However, colorectal cancer patients do not respond equally to radiation therapy. Researchers at OHSU have identified an RNA signature comprised of a microRNA and 4 target genes (mRNAs) that can differentiate between...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Vassiliki (liana) Tsikitis
Keywords(s): Diagnostics - Cancer
Category(s): Diagnostics
microRNA mimics and inhibitors to modulate genotoxic stress for cancer and aging related diseases.
MicroRNAs (miRs) can regulate gene expression and are often critical players in controlling cellular DNA repair mechanisms. miRs can therefore provide an alternative therapeutic strategy for treatment of cancer and other diseases associated with altered miR expression and/or DNA damage repair.Researchers at OHSU have identified a cohort of miRs that...
Published: 6/15/2017   |   Inventor(s): Sudarshan Anand, Maria (cristina) Espinosa-Diez
Keywords(s): Diagnostics, Therapeutics
Category(s): Diagnostics, Therapeutics
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