Search Results - therapeutics+-+infectious+diseases

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Malaria transmission blocking using ELQ-infused bed nets

Summary Insecticide-treated mosquito bed nets reduce the transmission of malaria, but mosquitos have developed resistance to insecticides leading to reduced efficacy. Our new technology is a chemical solution for mosquito nets that kills malaria, is less prone to drug-resistance and is not toxic to humans. Technology Overview Insecticide-treated...

Published: 10/15/2024 | Inventor(s): Michael Riscoe, Aaron Nilsen, Joseph (Stone) Doggett, Flaminia Catteruccia, Douglas (Doug) Paton

Keywords(s): Therapeutics, Therapeutics - Infectious Diseases, Therapeutics - Other

Category(s): Therapeutics, Device, Chemical

Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets

Summary Researchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel...

Published: 9/21/2023 | Inventor(s): Sunil Sundalam, Michael Cohen

Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases

Category(s): Chemical, Research Tools, Therapeutics

Cloroquine replacement drugs

Summary Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of antimalarial compounds that are superior to the standard of care. Technology Overview Malaria remains one of the deadliest diseases in the world today, as it has been for thousands of years. For each of...

Published: 9/22/2022 | Inventor(s): Michael Riscoe, Rolf Winter, Sovitj Pou, David Hinrichs, Jane Kelly, Yuexin Li, Aaron Nilsen

Keywords(s): Therapeutics, Therapeutics - Infectious Diseases

Category(s): Therapeutics, Chemical