Search Results - therapeutics+-+immunology

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Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets

Summary Researchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel...

Published: 9/21/2023 | Inventor(s): Sunil Sundalam, Michael Cohen

Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases

Category(s): Chemical, Research Tools, Therapeutics

Compounds that bind macrophage migration inhibitory factor

Summary Recombinant polypeptide composition, which selectively block key pro-inflammatory factors that could stop multiple sclerosis (MS) progression. Technology Overview MIF acts on the immune system to recruit inflammatory factors within injured tissues, including the central nervous system in MS. Upon binding to its receptor, CD74, MIF activates...

Published: 9/21/2023 | Inventor(s): Arthur Vandenbark, Gil Benedek, Roberto Meza-Romero

Keywords(s): Therapeutics, Therapeutics - Immunology

Category(s): Therapeutics