Search Results - robert+strongin

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Robert Strongin and his lab focus on dyes and fluorescing compounds for use in a variety of applications. Recently, they have developed new compounds for the colorometric detection of glutathione. The compounds are useful in detecting thiols generally, but can also be used to selectively detect glutathione, cysteine, and homocysteine. Current...

Published: 9/11/2019 | Inventor(s): Robert Strongin

Keywords(s):

Category(s): Chemistry

Modulating Activity of Calcium Release Channels

Using a new assay for drug development (see Abrj-01), PSU researchers have developed new compounds that may prove useful in the treatment of heart arrhythmia. Ventricular arrhythmias appear to be caused by a calcium leak from the sarcoplasmic reticulum in cardiac muscle, and arrhythmias often lead to heart failure. Drugs that prevent and treat arrhythmias...

Published: 2/22/2021 | Inventor(s): Jonathan Abramson, Robert Strongin

Keywords(s): Chemistry, Therapeutics

Category(s): Therapeutics

Fluorophore-Tagged Cisplatin

Many types of cancer, including carcinomas, lymphomas, sarcomas, and others, are treated with the chemotherapy agent Cisplatin. Based on the element platinum, cisplatin causes apoptosis in cancer cells by cross-linking their DNA. Like many chemotherapy agents, Cisplatin's effectiveness could be improved by better understanding how the body moves it...

Published: 1/18/2019 | Inventor(s): Robert Strongin, Martha Sibrian-Vazquez, Jorge Escobedo, Peter Streyger

Keywords(s): Biology, Chemistry, Drug Screening, Therapeutics

Category(s): Therapeutics

New Dyes for Forensic Applications

Fingerprints are the most common and useful physical evidence for the apprehension and conviction of crime perpetrators. Reagents for the detection and enhancement of fingerprints are among the most useful tools in this regard. However, the available fluorogenic reagents for detecting and enhancing fingerprints left in blood have several associated...

Published: 1/18/2019 | Inventor(s): Robert Strongin, Martha Sibrian-Vazquez

Keywords(s): Forensics

Category(s): Chemistry