Search Results - jonathan+abramson

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Modulating Activity of Calcium Release Channels

Using a new assay for drug development (see Abrj-01), PSU researchers have developed new compounds that may prove useful in the treatment of heart arrhythmia. Ventricular arrhythmias appear to be caused by a calcium leak from the sarcoplasmic reticulum in cardiac muscle, and arrhythmias often lead to heart failure. Drugs that prevent and treat arrhythmias...

Published: 2/22/2021 | Inventor(s): Jonathan Abramson, Robert Strongin

Keywords(s): Chemistry, Therapeutics

Category(s): Therapeutics

Screen for Redox Activity of Compounds

The design of new and effective drugs is a multi-billion dollar business, requiring great expense and extensive testing of drug candidate compounds. Obtaining a better understanding of the pharmacodynamics and mechanisms of action of drug candidates is an important and necessary step in optimizing any lead compound. A property of increasing...

Published: 1/18/2019 | Inventor(s): Jonathan Abramson, Benjamin Marinov, Rotimi Olojo

Keywords(s): Biology, Chemistry, Drug Screening

Category(s): Therapeutics