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Substituted Phenols and Benzenes for Pharmaceuticals, Agrochemicals and Synthetic Materials

Technology Description This technology licensing opportunity is for novel phenol and benzene compounds with any number of substituents and complete positional selectivity. Synthesis of the compounds is achieved by a new synthetic method. The method provides a one-step conversion of readily available starting materials to give phenols with complete...

Published: 5/23/2023 | Inventor(s): Chris Beaudry, Xiaojie Zhang

Keywords(s): agrochemical, benzenes, chemistry, medicinal, organic, pharmaceuticals, phenols, polymer, substituted, synthesis

Category(s): Agricultural, Chemical, Therapeutics

Modulating Activity of Calcium Release Channels

Using a new assay for drug development (see Abrj-01), PSU researchers have developed new compounds that may prove useful in the treatment of heart arrhythmia. Ventricular arrhythmias appear to be caused by a calcium leak from the sarcoplasmic reticulum in cardiac muscle, and arrhythmias often lead to heart failure. Drugs that prevent and treat arrhythmias...

Published: 2/22/2021 | Inventor(s): Jonathan Abramson, Robert Strongin

Keywords(s): Chemistry, Therapeutics

Category(s): Therapeutics

Fluorophore-Tagged Cisplatin

Many types of cancer, including carcinomas, lymphomas, sarcomas, and others, are treated with the chemotherapy agent Cisplatin. Based on the element platinum, cisplatin causes apoptosis in cancer cells by cross-linking their DNA. Like many chemotherapy agents, Cisplatin's effectiveness could be improved by better understanding how the body moves it...

Published: 1/18/2019 | Inventor(s): Robert Strongin, Martha Sibrian-Vazquez, Jorge Escobedo, Peter Streyger

Keywords(s): Biology, Chemistry, Drug Screening, Therapeutics

Category(s): Therapeutics

Solution-Based Synthesis of Functional Graphene

PSU researchers have developed techniques to covalently attach single and multiple layers of graphene sheets on substrates. The graphene can subsequently be functionalized for use in nanobiosensor applications. Procedures are being developed for the solution-based synthesis and functionalization of graphene sheets from graphite in a way that is straightforward,...

Published: 2/17/2021 | Inventor(s): Mingdi Yan, Li-Hong Liu

Keywords(s): Chemistry, Nanotechnology

Category(s): Chemistry

Screen for Redox Activity of Compounds

The design of new and effective drugs is a multi-billion dollar business, requiring great expense and extensive testing of drug candidate compounds. Obtaining a better understanding of the pharmacodynamics and mechanisms of action of drug candidates is an important and necessary step in optimizing any lead compound. A property of increasing...

Published: 1/18/2019 | Inventor(s): Jonathan Abramson, Benjamin Marinov, Rotimi Olojo

Keywords(s): Biology, Chemistry, Drug Screening

Category(s): Therapeutics

Cleaner, Less Expensive Amine Production

PSU researchers and their collaborators have uncovered and engineered a new class of enzymes - the nitrile oxido reductases - that can aid in the chemical production of amines. In today's society, chemical manufacturing industries are facing increasing demands to practice environmentally conscientious methods and processes. Like all businesses, they...

Published: 8/16/2013 | Inventor(s): Dirk Iwata-Reuyl, Valerie De Crecy-Lagard, Steven Van Lanen

Keywords(s): Chemistry

Category(s): Chemistry