Search Results - diagnostics

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Machine-learning based forecasting of visual field deficits for glaucoma management

Summary The current technology is a machine learning algorithm that can accurately forecast glaucoma-induced visual field deficits and outperforms existing forecasting methods. This technology could allow for more efficient management of glaucoma by reducing the number of office-based visual field assessments. Technology Overview Glaucoma is characterized...

Published: 8/15/2024 | Inventor(s): Ashkan Abbasi, Hiroshi Ishikawa, Sowjanya Gowrisankaran, Xubo Song, Bhavna Antony, Gadi (Chaim) Wollstein, Joel Schuman

Keywords(s): Diagnostics, Diagnostics - Other, Software, Software - Diagnostic/Detection

Category(s): Diagnostics, Software

Protease Activity Sensing Probes For Early Detection and Prognosis of Pancreatic Cancer

Summary The current technology is a liquid biopsy diagnostic screen for pancreatic ductal adenocarcinoma (PDAC), which is high throughput, requires very small blood volumes and has been validated in a large patient dataset. Technology Overview Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is typically discovered by accident...

Published: 7/31/2024 | Inventor(s): Jared Fischer, Jose Luis Montoya Mira

Keywords(s): Diagnostics, Diagnostics - Cancer

Category(s): Diagnostics

CD74 as a biomarker and therapeutic target for familial platelet (FPD) disorder

Summary Research at OHSU has identified the CD74 signaling cascade as a potential therapeutic target and diagnostic biomarker for RUNX1-mutated familial platelet disorder (FPD), which is a premalignant condition for acute myeloid leukemia. Technology Overview Current estimates suggest as many as 18,000 people may be living with RUNX1-FPD in the United...

Published: 2/27/2024 | Inventor(s): Anupriya Agarwal, Mona Mohammadhosseini

Keywords(s): Diagnostics, Diagnostics - Cancer, Diagnostics - Other, Therapeutics, Therapeutics - Cancer, Therapeutics - Other

Category(s): Diagnostics, Therapeutics

Nanoparticle ultrasound contrast agents with high acoustic activity

Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...

Published: 11/22/2023 | Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen

Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics

Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics

Novel single-gene biomarker for acute myeloid leukemia prognosis

Summary The current technology is a novel set of biomarkers derived from the largest ever genomic and transcriptomic data set for acute myeloid leukemia (AML), which includes a novel single gene biomarker capable of strongly predicting AML prognosis. Technology Overview Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with an incidence...

Published: 9/27/2023 | Inventor(s): Daniel Bottomly, Brian Druker, Kara Johnson, Stephen (Steve) Kurtz, Nicola Long, Shannon McWeeney, Anna Reister Schultz, Cristina Tognon, Jeffrey (Jeff) Tyner

Keywords(s): Diagnostics, Diagnostics - Cancer

Category(s): Diagnostics

Improved detection of heart-rate variability for wearable devices

Summary Heart-rate variability (HRV) is a suggested marker of the autonomic nervous system, but artifacts produced by movement with wrist worn devices decreases the validity and utility of this data. Oregon Health & Science University researchers have developed an improved method of removing motion artifacts, understanding the amount of data that...

Published: 3/24/2023 | Inventor(s): David Sheridan, Steven Baker, Ryan Dehart

Keywords(s): Diagnostics, Research Tools, Software

Category(s): Diagnostics, Research Tools, Software

Anoxic/hypoxic brain imaging map

Summary Brain damage in newborns arises as a consequence of oxygen shortage in the brain. This injury is often difficult to diagnose in young children due to intrinsic differences between the developing and adult brain. Scientists at OHSU have developed a highly-accurate diagnostic analysis to localize brain injuries in developing as well as adult brains....

Published: 3/16/2023 | Inventor(s): Jeffrey Pollock, Ningcheng (Peter) Li

Keywords(s): Diagnostics, Diagnostics - Neurology, Imaging, Imaging - MRI

Category(s): Diagnostics, Imaging

Effective combinations of targeted agents for hematologic malignancies

Summary Current treatment strategies for acute myeloid leukemia (AML) have low efficacy rates, due in part to the complex and heterogenous underlying genetics of this cancer. Oregon Health & Science University researchers have developed a precision medicine approach for the treatment of AML by identifying an effective combination therapy for a specific...

Published: 9/27/2023 | Inventor(s): Jeffrey (Jeff) Tyner, Elie Traer, Stephen (Steve) Kurtz, Brian Druker, Andrew Kaempf, Christopher (Chris) Eide, Motomi (Tomi) Mori

Keywords(s): Diagnostics, Diagnostics - Cancer

Category(s): Diagnostics

Metabolic activity diffusion imaging (MADI): dye-free, high-resolution MRI metabolic imaging

Summary The current technology is a contrast agent-free method of metabolic imaging based on detection of Na/K ATPase activity with MRI, that provides significantly higher resolution than current approaches such as PET. Technology Overview Measuring metabolic activity in vivo can facilitate diagnoses of disease states and therapeutic responses....

Published: 1/15/2024 | Inventor(s): Gregory Wilson, Jeffrey Maki, Charles Springer, Jr., Xin Li, William (Bill) Rooney, Brendan Moloney, Wei Huang, Tom Barbara, Eric Baker

Keywords(s): Diagnostics, Imaging, Imaging - MRI, Software, Software - Other

Category(s): Imaging, Software

Label-free fluorescent sensing of protease activity

Summary The current technology offers advantages over existing protease probes, with lower background noise, simplified label-free synthesis, compatibility with any protease of interest and utility for translational research and clinical diagnostics. Technology Overview Dysregulated proteolytic activity is linked to many human diseases, including...

Published: 7/19/2024 | Inventor(s): Adem Yildirim, Bruce Branchaud, Justin Plaut, Srivathsan Ranganathan, Sean Speese, Corey Dambacher, Sarah Barnhill, Emma Olson

Keywords(s): Diagnostics, Imaging, Imaging - Other, Research Tools

Category(s): Imaging, Research Tools, Diagnostics

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