Search Results - biological+materials+-+cell+lines

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ImmortaMAITs: immortalized Mucosal Associated Invariant T (MAIT) cells as new human cell line reagents for human immunobiology research

Technology Overview The Immorta-MAITs are human mucosal-associated invariant T (MAIT) cells. There are ten cell lines which are confirmed to express the MAIT T cell receptor alpha (TRAV1-2) and full TCR sequencing has been performed. The cell lines stain with an MR1-tetramer loaded with a MAIT antigen 5-OP-RU and not control MR1-tetramer loaded with...

Published: 5/16/2023 | Inventor(s): Erin Meermeier (Riscoe), Irina Kurtz, David Lewinsohn, Marielle Gold

Keywords(s): Biological Materials - Cell Lines

Category(s): Biological Materials

A method to increase pregnancy rates for treatment of infertility

Summary A method of generating functional human oocytes from polar bodies, which could be utilized to increase viable oocyte retrieval and prevent transmission of inherited mitochondrial DNA mutations. Technology Overview Because of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss,...

Published: 11/3/2022 | Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez, Dmitry Temiakov

Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive

Category(s): Biological Materials, Therapeutics

In vitro fertilization: Spindle transfer method for mitochondrial DNA replacement to circumvent genetically inherited genetic disorders

Summary The current technology is method of preventing mitochondrial DNA disease transmission through oocyte spindle transfer. Technology Overview Mitochondria, cytoplasmic organelles containing their own DNA (mtDNA), are crucial for the cell as they supply the cell with the majority of energy needed for basic cellular functions. mtDNA is transmitted...

Published: 9/21/2022 | Inventor(s): Shoukhrat Mitalipov

Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive

Category(s): Engineering, Biological Materials, Therapeutics

A cellular model for human pantothenate kinase 2 dysfunction

Technology Overview Researchers at Oregon Health & Science University have developed the first and only cell based PKAN model whereby human fibroblasts with respiratory dysfunction are maintained and utilized to screen compounds for biological activity against PKAN cellular phenotypes associated with PANK2 gene mutations. Licensing Opportunity This...

Published: 9/29/2022 | Inventor(s): Susan Hayflick, Suh Young Jeong

Keywords(s): Biological Materials - Cell Lines, Research Tools - Screening

Category(s): Research Tools

BB19 cell line

Technology Overview The current technology is an immortalized human brain capillary endothelial cell line named BB19. BB19 cells are derived from human brain endothelium and are immortalized with E6E7 genes of human papilloma virus. This cell line has been used to study cytoadherence of Plasmodium falciparum-infected erythrocytes in vitro. The...

Published: 7/16/2024 | Inventor(s): Jay Nelson, Ashlee Moses

Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening

Category(s): Biological Materials

C-Terminal Binding Protein (CtBP) single isoform lentiviral stable cell lines

Technology Overview These cell lines re-introduce CtBP wild type and functional mutant isoforms (both CtBP1 and 2) back into a CtBP1+2 null mouse embryonic fibroblast (MEF) line. These cells contain lentiviral-introduced protein encoding sequences that allow for stable expression of physiologic levels of CtBP isoforms under the tetracycline operon...

Published: 9/21/2022 | Inventor(s): Dana Madison, James Lundblad, Damian Curtis

Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Reagents

Category(s): Biological Materials