Search Results - shoukhrat+mitalipov

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Method of producing human pluripotent stem cells by somatic cell nuclear transfer

Summary This is a method for producing patient-matched histocompatible pluripotent stem cells (PSC’s) by somatic cell nuclear transfer (SCNT). Technology Overview Pluripotent stem cells only naturally exist in early human embryos. The current methods produce experimental pluripotent stem cells (PSC’s) using the patient’s own skin...

Published: 4/8/2024 | Inventor(s): Shoukhrat Mitalipov, Masahito Tachibana

Keywords(s): Research Tools, Therapeutics, Therapeutics - Reproductive

Category(s): Biological Materials, Therapeutics

CRISPR/Cas9-targeted correction of heterozygous mutations in human preimplantation embryos

Technology Overview More than 10,000 monogenic inherited disorders have been identified, affecting millions of people worldwide. Among these are the autosomal dominant mutations, where inheritance of a single copy of a defective gene can result in clinical symptoms. Dominant mutations that manifest as late-onset adult disorders include BRCA1 and BRCA2,...

Published: 9/30/2022 | Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez

Keywords(s): Therapeutics - Reproductive

Category(s): Therapeutics

A method to increase pregnancy rates for treatment of infertility

Summary A method of generating functional human oocytes from polar bodies, which could be utilized to increase viable oocyte retrieval and prevent transmission of inherited mitochondrial DNA mutations. Technology Overview Because of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss,...

Published: 11/3/2022 | Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez, Dmitry Temiakov

Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive

Category(s): Biological Materials, Therapeutics

In vitro fertilization: Spindle transfer method for mitochondrial DNA replacement to circumvent genetically inherited genetic disorders

Summary The current technology is method of preventing mitochondrial DNA disease transmission through oocyte spindle transfer. Technology Overview Mitochondria, cytoplasmic organelles containing their own DNA (mtDNA), are crucial for the cell as they supply the cell with the majority of energy needed for basic cellular functions. mtDNA is transmitted...

Published: 9/21/2022 | Inventor(s): Shoukhrat Mitalipov

Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive

Category(s): Engineering, Biological Materials, Therapeutics