Technology Overview Monoclonal antibody (10D4) against the β subunit of human epithelial sodium channel (hENaC). The antibody recognizes the tertiary, 3D epitope of the beta subunit and is characterized as IgG1 with a kappa light chain. It binds with high affinity and specificity to the respective subunits constituting hENaC.
Epithelial sodium channels (ENaC) are involved in regulating Na+ homeostasis. ENaCs primarily require three different subunits to form a functional channel, α, β and γ.
Potential uses include:
Publication Noreng S et al., “Structure of the human epithelial sodium channel by cryo-electron microscopy.” Elife. 2018;7:e39340. Link
Licensing Opportunity This technology is available for licensing.