Monoclonal antibody (7B1) against the α subunit of human epithelial sodium channel (hENaC)

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Monoclonal antibody (7B1) against the α subunit of the human epithelial sodium channel (hENaC). The antibody recognizes the tertiary, 3D epitope of the alpha subunit and is characterized as IgG2 with a kappa light chain. It binds with high affinity and specificity to the respective subunits constituting hENaC.


Epithelial sodium channels (ENaC) are involved in regulating Na+ homeostasis. ENaCs primarily require three different subunits to form a functional channel, α, β and γ.

Potential uses:

•       purification of human ENaC for structure studies with an ability to purify and study ENaC from recombinant or native source;

•       determination of cellular location of the heterotrimeric ENaC by immunohistochemistry or immunocytochemsitry;

•       differentiate ENaC formed from αβγ or δβγ subunits;

•       live detection of hENaC subunits in vivo following immunofluorescence labeling;

•       application for immunoprecipitation of intact heteromeric ENaC; and

•       identification of human ENaC protein-expressing cells.


Relevant publication:

Noreng S, Bharadwaj A, Posert R, Yoshioka C, Baconguis I. Structure of the human epithelial sodium channel by cryo-electron microscopy. Elife. 2018;7:e39340. Published 2018 Sep 25. doi:10.7554/eLife.39340. (



Patent Information:
Biological Materials
For Information, Contact:
Lisa Lukaesko
Technology Development Manager
Oregon Health & Science University
Isabelle Baconguis
Arpita Bharadwaj
Biological Materials
Biological Materials - Antibodies
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