Search Results - michael heinrich

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Diagnosis of Human Malignances Associated with Activating Mutations of Platelet Derived Growth Factor Receptor Alpha (PDGFRA)
Tyrosine kinases are expressed in many human cancers and are attractive targets for the development of anticancer therapies. Clinical response to these therapies is often correlated with the mutational status of the target. The identification of a particular mutation in a patient’s tumor therefore can be used to identify which patients are m...
Published: 6/15/2017   |   Inventor(s): Michael Heinrich, Christopher Corless, Jonathon Fletcher, George Demitri
Keywords(s): Diagnostics
Category(s): Diagnostics
pLXSN human KIT V654A + D816Y
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816Y cell line and drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retroviru...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT V654A + D816F
Technology OverviewThis line was created by ENU-mutagenesis of BaF3 pLXSN KIT D816F cell line and subsequent drug selection. The V654A mutation is associated with imatinib-resistance in GIST. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due ...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT D816F retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due to retrovirus recombination events: I571M and M903I. These secondary events do not appear to alter the kinase properties of ...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
pLXSN human KIT D816Y retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816Y mutation, the cells also acquired the following mutations due to retrovirus recombination events: N587S and deletion of amino acids 931-961. These secondary events do not appear to alter...
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
M5gNeo human KIT D816V retrovirally transduced BaF3 cells
Technology OverviewNeomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. No mutation of KIT except for D816V.
Published: 1/29/2015   |   Inventor(s): Michael Heinrich
Keywords(s): Biological Materials, Biological Materials - Cell Lines, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
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