Search Results - biological+materials+-+mice

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SK3 Floxed Allele Mice (SK3 Null Mice)
Technology Overview In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. ...
Published: 9/16/2020   |   Inventor(s): John Adelman, Chris Bond, James Maylie
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Transgenic mice expressing a red fluorescent protein in proopiomelanocortin neurons, granule cell neurons of the hippocampal dentate gyrus, pituitary corticotrophs, and pituitary melanotrophs
This technology is a transgenic mouse strain expressing a red fluorescent protein in proopiomelanocortin (POMC) neurons, granule cell neurons of the hippocampal dentate gyrus, pituitary corticotrophs, and pituitary melanotrophs. Jackson Lab Stock #009593.
Published: 9/16/2020   |   Inventor(s): Malcolm Low, Veronica Otero-Corchon, Marcelo Rubinstein
Keywords(s): Biological Materials, Biological Materials - Mice
Category(s): Biological Materials, Research Tools
CyP-D Knock-Out Mice
Technology OverviewCyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies. These animals and their cells...
Published: 9/16/2020   |   Inventor(s): Michael Forte, Paolo Bernardi, Emy Basso
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Small-Conductance CA2+-Activated Potassium Channel 2 (SK2) Transgenic Mice
Technology OverviewIn excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. In...
Published: 9/16/2020   |   Inventor(s): John Adelman, Chris Bond, James Maylie
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Small-Conductance CA2+-Activated Potassium Channel 1 (SK1) Transgenic Mice
Technology OverviewIn excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types. In...
Published: 9/16/2020   |   Inventor(s): John Adelman, Chris Bond, James Maylie
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
POMC transgenic mice and neuron-specific promoter
Technology OverviewPOMC neurons of the hypothalamus are critical components of the neural circuitry controlling appetite, feeding, and metabolism. In addition they modulate the activity of other hypothalamic neurons which control reproduction, thyroid hormone levels, growth hormone secretion and neuroendocrine stress responses. Genetic evidence in humans...
Published: 9/16/2020   |   Inventor(s): Malcolm Low, Marcelo Rubinstein, Flavio Silva De Souza
Keywords(s): Biological Materials, Biological Materials - Mice, Therapeutics, Therapeutics - Neurology
Category(s): Research Tools
Small-Conductance Ca2+-Activated Potassium Channel 3 (SK3) transgenic mice
Technology Overview In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. These channels are found in many types of neurons as well as in some other cell types....
Published: 9/16/2020   |   Inventor(s): Chris Bond, John Adelman
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Melanocortin-3 Receptor Knockout Mice
Technology OverviewThe central melanocortin system is critical for the long term regulation of energy homeostasis. Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, obesity, and accelerated longitudinal growth in mice and humans. To assess the role of the melanocortin-3 receptor (MC3-R) in energy homeostasis,...
Published: 9/16/2020   |   Inventor(s): Roger Cone, Andrew Butler, Robert Kesterson
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Pms-2 Knockout Mouse
Technology OverviewMutations in the DNA mismatch repair pathway have been shown to be involved in the development of certain cancers. PMS2 is one of the genes involved in the DNA mismatch/repair pathway. PMS2 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for...
Published: 9/16/2020   |   Inventor(s): Robert Liskay, C. Eric Bronner, Sean Baker, Richard Flavell
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
D2 Dopamine Receptor Knock-Out Mice
Technology OverviewD2R is the gene for the D2 dopamine receptor and encodes a member of the D2-like class of dopamine receptors. It is one of the most abundant dopaminergic receptors expressed in the brain. This strain could be used to screen and assess agonist and antagonist drugs specific to the D2 receptor. These mutant mice, technology #...
Published: 9/16/2020   |   Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein, Michele Kelly
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
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