Search Results - biological materials - mice

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Snm1 Mutant Mouse Strain
This technology is transgenic mouse strain with a targeted mutation of the DNA cross-link repair 1A, PSO2 homolog (Dclre1a) gene displays an increased sensitivity to mitomycin C and may be useful in the study of genomic stability. This mouse can be found as Jackson Lab Stock # 010524.Additional information can be foudn at Mol Genet Metab. 2008 Ma...
Published: 3/8/2017   |   Inventor(s): Robb Moses
Keywords(s): Biological Materials - Mice
Category(s): Biological Materials
Transgenic mice expressing a red fluorescent protein in proopiomelanocortin neurons, granule cell neurons of the hippocampal dentate gyrus, pituitary corticotrophs, and pituitary melanotrophs
This technology is a transgenic mouse strain expressing a red fluorescent protein in proopiomelanocortin (POMC) neurons, granule cell neurons of the hippocampal dentate gyrus, pituitary corticotrophs, and pituitary melanotrophs. Jackson Lab Stock #009593.
Published: 12/21/2016   |   Inventor(s): Malcolm Low, Veronica Otero-Corchon, Marcelo Rubinstein
Keywords(s): Biological Materials, Biological Materials - Mice
Category(s): Biological Materials, Research Tools
C57BL6-Pahenu2 mouse
The C57BL6-Pahenu2 mouse is a model of the human disease phenylketonuria (PKU). The mouse was originally on the BTBR genetic background but the mutation was outbred to the C57BL6 background to facilitate breeding. There is no other commercial source for this mouse model.
Published: 4/20/2016   |   Inventor(s): Cary Harding
Keywords(s): Biological Materials - Mice
Category(s): Biological Materials
MC5-R Knockout mice
Technology # 0387-B OverviewMC5-R is responsive to all melanocortins at physiological levels except g-MSH. The melanocortin-5 receptor (MC5-R) is found in a wide range of tissues from skeletal muscle, to adipose tissues, brain, lung, adrenal and stomach. Provided by this invention is a mouse model with a disruption of the MC5-R gene with a severe ...
Published: 1/29/2015   |   Inventor(s): Roger Cone, Malcolm Low, Wenbiao Chen
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Flagmor transgenic mouse
Value PropositionFLAGMOR transgenic mice provides an advantage to studying signal transduction of mu-opioid receptors (MOR) through the activation of potassium-ion channels, desensitization, and receptor trafficking. A better understanding of the underlying mechanisms of MOR activation will lead to improved opioid treatment and research. Tech...
Published: 4/30/2010   |   Inventor(s): John Williams
Keywords(s): Biological Materials, Biological Materials - Mice
Category(s): Biological Materials
CyP-D Knock-Out Mice
Technology OverviewCyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies. These animals and their ...
Published: 4/28/2010   |   Inventor(s): Michael Forte, Paolo Bernardi, Emy Basso
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
POMC transgenic mice and neuron-specific promoter
Technology OverviewPOMC neurons of the hypothalamus are critical components of the neural circuitry controlling appetite, feeding, and metabolism. In addition they modulate the activity of other hypothalamic neurons which control reproduction, thyroid hormone levels, growth hormone secretion and neuroendocrine stress responses. Genetic evidence in ...
Published: 4/28/2010   |   Inventor(s): Malcolm Low, Marcelo Rubinstein, Flavio Silva De Souza
Keywords(s): Biological Materials, Biological Materials - Mice, Therapeutics, Therapeutics - Neurology
Category(s): Research Tools
D2 Dopamine Receptor Knock-Out Mice
Technology OverviewD2R is the gene for the D2 dopamine receptor and encodes a member of the D2-like class of dopamine receptors. It is one of the most abundant dopaminergic receptors expressed in the brain. This strain could be used to screen and assess agonist and antagonist drugs specific to the D2 receptor. These mutant mice, technology #...
Published: 4/28/2010   |   Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein, Michele Kelly
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
D4 Dopamine Receptor Knock-Out Mice
Technology OverviewResearchers at OHSU have developed technology # 0379, a strain of mice that are genetically deficient in the D4 dopamine receptor. These mice provide a new animal model for the study of the function of the D4 receptor. Homozygous mice may exhibit locomotor supersensitivity to ethanol, cocaine, and methamphetamine, as well...
Published: 4/28/2010   |   Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
Melanocortin-3 Receptor Knockout Mice
Technology OverviewThe central melanocortin system is critical for the long term regulation of energy homeostasis. Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, obesity, and accelerated longitudinal growth in mice and humans. To assess the role of the melanocortin-3 receptor (MC3-R) in energy homeostasi...
Published: 2/10/2010   |   Inventor(s): Roger Cone, Andrew Butler, Robert Kesterson
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
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