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Split-luciferase complementation to measure soluble epoxide hydrolase dimerization

Technology Overview Soluble epoxide hydrolase (sEH) inhibition is a therapeutic target for a large number of cardiovascular diseases. Disrupting dimerization of sEH reduces hydrolase activity and shifts the sub-cellular localization of sEH to peroxisomes. The current technology is a split-firefly luciferase assay that not only measures disruption of...

Published: 9/19/2023 | Inventor(s): Jonathan Nelson, Nabil Alkayed, Xiangshu Xiao

Keywords(s): Biological Materials, Research Tools - Screening

Category(s): Biological Materials, Research Tools