Bioactive Polymers with Anti-Fouling Properties for Medical Implants

Case ID:
2850
Web Published:
5/11/2021
Description:

Summary

The development of bacterial biofilms can affect the structural integrity of in-dwelling medical devices and materials, reducing their longevity. Oregon Health & Science University researchers have developed bioactive polymers, which are compatible with traditional dental reconstruction materials and reduce biofilm formation to potentially increase the durability of medical implants, including dental restorations.

 

Technology Overview

Indwelling medical devices and materials are highly susceptible to bacterial colonization, and these bacterial biofilms can be detrimental to the durability of the device. Current methods to control biofilm formation are limited to small molecule rinses, which must be regularly administered, and small molecule sustained release (i.e. leaching), which is eventually depleted. OHSU researcher Dr. Carmem Pfeifer has devised a strategy to incorporate biofilm disrupting (anti-fouling) small-molecule polymers into medically relevant plastics. These materials offer several advantages:

•       Demonstrated reduction of S. mutans colonization, an early bacterial colonizer with virulent biofilms that erode dental enamel,

•       Lack of broad anti-bacterial properties, allowing for tailored biological activity and prevention of bacterial imbalance,

•       Compatibility with dental restoration materials, and

•       Applicability for wide range of medical devices.

 

Licensing Opportunity

This technology is available for exclusive or non-exclusive licensing.

 

Patent Information:
Category(s):
Dental
Materials Science
For Information, Contact:
Trina Voss
Technology Development Manager
Oregon Health & Science University
503-494-8200
vosst@ohsu.edu
Inventors:
Carmem Pfeifer
Matthew Logan
Alexander Kendall
Ana Paula Piovezan Fugolin
Steven Lewis
Keywords:
Dental
Dental - Coating & Composites
Device - Other
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