Gonorrhea Vaccine

Case ID:
OSU-19-33
Web Published:
1/30/2020
Description:

Technology Description

Oregon State University is seeking a licensee to develop and commercialize a gonorrhea subunit vaccine. The formulated vaccine induces a protective immune response that results in accelerated Ng clearance from the murine lower genital tract and thus provides a subunit vaccine for further gonorrhea vaccine development. To assess whether immunization with the vaccine induces a protective immune response, the inventors conducted large scale experiments in biological replicates in which groups of 20 BALB/c mice were given the formulated vaccine. Control groups consisted of mice given adjuvant alone or PBS using the same immunization routes and time points. The vaccine elicited high serum antibody titers and sera as well as mucosal secretions. Significantly higher titers of total IgG, IgG1, Ig2a, and IgA were detected in sera of immunized mice. Combined biological replicate challenge experiments demonstrated that mice immunized with the vaccine cleared gonococcal infection significantly faster compared to unimmunized mice (p<0.0001) and adjuvant control mice (p=0.0013). Seventy-five and ninety percent of mice immunized cleared infection by day five and seven.

Background of Invention

Each year witnesses roughly 78 million new gonorrhea infections worldwide. While often asymptomatic (particularly in females), untreated infection can lead to pelvic inflammatory disease, ectopic pregnancy, infertility, and increased transmission/acquisition of HIV. Although antimicrobials have been the standard treatment for gonorrhea, Neisseria gonorrhoeae (Ng) has developed resistance to all antimicrobials used in empiric treatment. WHO, CDC, and other public health organizations have raised an urgent call for an effective gonorrhea vaccine, noting that this may be the only sustainable solution to reduce the disease burden and control its global spread.

Status

Patent Pending (U.S. provisional patent application)

   

Patent Information:
Category(s):
Vaccines
For Information, Contact:
Joe Christison
IP & Licensing Manager
Oregon State University
541-737-9016
joe.christison@oregonstate.edu
Inventors:
Aleksandra Sikora
Ryszard Zielke
Ann Jerse
Keywords:
Gonorrhea
vaccine
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