Search Results - siva+kolluri

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New Drugs for Treatment of Type 1 Diabetes

Background Type 1 diabetes (T1D) is a life-threatening autoimmune disease that usually appears in childhood without warning. Current treatment options involve the administration of various insulin analogs and auxiliary therapies. The global market for T1D treatment is over $25 billion and growing. T1D is caused by the immune-mediated destruction...

Published: 6/10/2024 | Inventor(s): Siva Kolluri, Nancy Kerkvliet, Jit Chakravarty, Sebastian Bernales

Keywords(s): Diabetes, pharmaceuticals, Therapeutic, Type 1 Diabetes

Category(s): Therapeutics

Anti-cancer Compounds

Technology Description This technology describes using compounds to induce cell death in Bcl-2 high-expressing cancer cells refractory to chemotherapeutic drugs but with minimal effects on normal cells. Further, the anti-cancer effect of these compounds is also confirmed in mouse xenograft studies. These results indicate that our compounds are effective...

Published: 1/7/2022 | Inventor(s): Siva Kolluri, Prasad Kopparapu

Keywords(s): Cancer, metastatic tumor, small peptides

Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics

New Approach for Treatment of Type I Diabetes

Technology Description This licensing and collaborative research opportunity relates to a new approach to treating diabetes mellitus type 1 (T1DM). The patent pending methods of treatment focus on the use of compounds that provide suppression of autoimmune responses that lead to destruction of pancreatic beta cells. The possibility of preventing disease...

Published: 5/24/2023 | Inventor(s): Nancy Kerkvliet, Siva Kolluri

Keywords(s): Diabetes, Drug, Immune, Therapeutic

Category(s): Chemical, Therapeutics